Protein Alignment InR and EPHA4

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_004429.1
• Gene: EPHA4 / 2043
• HGNCID: 3388
• Length: 986
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 165/540 - (30%)
• Similarity: 250/540 - (46%)
• Gaps: 102/540 - (18%)

  Fly  1220 TESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEK-KCIPAADFNQTAGYLIKLNEGLYSFRV 1283
            |...|.:.|..|..|||.|:.|||.|  .:.||.|.. :.:..|..|.....|..|..  |.|.|
Human   453 TRYSVALAWLEPDRPNGVILEYEVKY--YEKDQNERSYRIVRTAARNTDIKGLNPLTS--YVFHV 513

  Fly  1284 RANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGL--AFLIVSLFGYVC-------------- 1332
            ||.:.||||||:|...:.....||.      ::|.|.  ..|:||:.|.|.
Human   514 RARTAAGYGDFSEPLEVTTNTVPSR------IIGDGANSTVLLVSVSGSVVLVVILIAAFVISRR 572

  Fly  1333 ---YLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRE-------NIIQLAP-LGQGSFGMVY 1386
               |...::....:.|:|..|..:.....| .|..:.:||       :.|::.. :|.|.||.|.
Human   573 RSKYSKAKQEADEEKHLNQGVRTYVDPFTY-EDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVC 636

  Fly  1387 EGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVM 1451
            .|.||  .|...:...||||:....||::|.:||||||:|.:||..:::.|.||.::.:|.:::.
Human   637 SGRLK--VPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIIT 699

  Fly  1452 ELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFV 1516
            |.|:.|.|.::||      :::...|.:..:|               |...|..||.||:...:|
Human   700 EYMENGSLDAFLR------KNDGRFTVIQLVG---------------MLRGIGSGMKYLSDMSYV 743

  Fly  1517 HRDLAARNCMVADDLTVKIGDFGMTR---DIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASD 1578
            ||||||||.:|..:|..|:.||||:|   |..|..|..:|  |.:|:||..||::....::||||
Human   744 HRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRG--GKIPIRWTAPEAIAYRKFTSASD 806

  Fly  1579 VFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSF 1643
            |:|:|:|:||:.:...:||..:||:.|::.:.:|..:..|.:||..||:||..||....|.||.|
Human   807 VWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKF 871

  Fly  1644 LDIIAYLEP--QCPNSQFKEVSFYHSEAGLQHREKERKERNQLD----AFAAVPLDQDLQDREQQ 1702
            ..|:..|:.  :.||| .|...          .|..|.....||    .|:||
Human   872 GQIVNMLDKLIRNPNS-LKRTG----------TESSRPNTALLDPSSPEFSAV------------ 913

  Fly  1703 EDATTPLRMGDYQQNSSLDQ 1722
                  :.:||:.|...:|:
Human   914 ------VSVGDWLQAIKMDR 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	30/78 (38%)
		PTKc_InsR_like	1364..1652	CDD:173625	104/298 (35%)
EPHA4	NP_004429.1	EphR_LBD_A4	30..203	CDD:198450
		FN3	329..436	CDD:238020
		FN3	441..532	CDD:238020	31/82 (38%)
		EphA2_TM	562..618	CDD:464211	8/56 (14%)
		PTKc_EphR_A	616..882	CDD:270651	102/290 (35%)
		SAM_EPH-A4	911..981	CDD:188944	6/35 (17%)
		PDZ-binding. /evidence=ECO:0000255	984..986