Protein Alignment InR and EPHA3

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_005224.2
• Gene: EPHA3 / 2042
• HGNCID: 3387
• Length: 983
• Species: Homo sapiens
• Alignment Length: 990
• Identity: 250/990 - (25%)
• Similarity: 390/990 - (39%)
• Gaps: 259/990 - (26%)

  Fly   738 VLD---NRDLDELWGPNQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPK-----FFEKSDVG 794
            |:|   |..|...|.|..:.  :|..|...|..:.|.|     :|::....|     ::.:||
Human    73 VMDHSQNNWLRTNWVPRNSA--QKIYVELKFTLRDCNS-----IPLVLGTCKETFNLYYMESD-- 128

  Fly   795 ADSNGNR------GSCGTAVLNVTLQSVGANSAMLNVTTKV-EIGEPQKPSNATIVFKDPRAFIG 852
             |.:|.:      ....|...:.:...:.....:|.:.|:: |:| |.......:.|:|..|.:.
Human   129 -DDHGVKFREHQFTKIDTIAADESFTQMDLGDRILKLNTEIREVG-PVNKKGFYLAFQDVGACVA 191

  Fly   853 FVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAES 917
            .|                               .|.|.....|:|     |:.:|:..:
Human   192 LV-------------------------------SVRVYFKKCPFT-----VKNLAMFPD------ 214

  Fly   918 DVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCT 982
                  |.|.....:.||..:.:::||..      |.|                      |.||:
Human   215 ------TVPMDSQSLVEVRGSCVNNSKEE------DPP----------------------RMYCS 245

  Fly   983 ---EPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDR--KVQAGME-FENALQN 1041
               |.||                  |: |.|.|..|        |::|  ..||... |..||..
Human   246 TEGEWLV------------------PI-GKCSCNAG--------YEERGFMCQACRPGFYKALDG 283

  Fly  1042 FIFVPNIR--KSKNGSSDKSDGAEGAALDSNAI------PNGGATNPSRRRRDVALEPELDDV-E 1097
                 |::  |....||.:.||:.....::|..      |:...|.|....|:|     :.:: |
Human   284 -----NMKCAKCPPHSSTQEDGSMNCRCENNYFRADKDPPSMACTRPPSSPRNV-----ISNINE 338

  Fly  1098 GSVLLRHVRSITDDT----DAFFE---KDDENTYKDEEDLSSNKQFYEVFAKELP-----PNQTH 1150
            .||:|..  |...||    |..|.   |......|..|..|.|.:|       ||     .|.|.
Human   339 TSVILDW--SWPLDTGGRKDVTFNIICKKCGWNIKQCEPCSPNVRF-------LPRQFGLTNTTV 394

  Fly  1151 FVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLE 1215
            .|.:.|.| |.|...:         :.:...|...|....:..|..||.:.. ...|:.:|.|..
Human   395 TVTDLLAH-TNYTFEI---------DAVNGVSELSSPPRQFAAVSITTNQAA-PSPVLTIKKDRT 448

  Fly  1216 HANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGLYS 1280
            ..|:    :.:.|..|..|||.|:.|||.| .:|.:|......:.|...|.|...|  ..:.:|.
Human   449 SRNS----ISLSWQEPEHPNGIILDYEVKY-YEKQEQETSYTILRARGTNVTISSL--KPDTIYV 506

  Fly  1281 FRVRANSIAGYGDFTEVEHIKVEPPP-------SYAKVFFWLLGIGLAFLIVS-----LFGYVC- 1332
            |::||.:.||||  |.....:.|..|       ..::|....:...:|.::::     |.|..|
Human   507 FQIRARTAAGYG--TNSRKFEFETSPDSFSISGESSQVVMIAISAAVAIILLTVVIYVLIGRFCG 569

  Fly  1333 YLHKRKVPSNDLH----------MNTEVNPFYASMQYIPDDWEVLRE--------NIIQLAPLGQ 1379
            |..|.......||          :.|.|:|     ....|..:.:.|        ||.....:|.
Human   570 YKSKHGADEKRLHFGNGHLKLPGLRTYVDP-----HTYEDPTQAVHEFAKELDATNISIDKVVGA 629

  Fly  1380 GSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRG 1444
            |.||.|..|.||.  |:..:...||||:....|:::|.:||.|||:|.:||..:::||.||.::.
Human   630 GEFGEVCSGRLKL--PSKKEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKS 692

  Fly  1445 QPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAY 1509
            :|.::|.|.|:.|.|.|:||.|      :|..|.:..:|               |...||.||.|
Human   693 KPVMIVTEYMENGSLDSFLRKH------DAQFTVIQLVG---------------MLRGIASGMKY 736

  Fly  1510 LAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR---DIYETDYYRKGTKGLLPVRWMPPESLRDG 1571
            |:...:|||||||||.::..:|..|:.|||::|   |..|..|..:|  |.:|:||..||::...
Human   737 LSDMGYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRG--GKIPIRWTSPEAIAYR 799

  Fly  1572 VYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHR 1636
            .::|||||:|:|:||||:.:...:||..:||:.|::.|.:|..:..|.:||..|::||..||...
Human   800 KFTSASDVWSYGIVLWEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKD 864

  Fly  1637 SSARPSFLDIIAYLE 1651
            .:.||.|..|::.|:
Human   865 RNNRPKFEQIVSILD 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032	12/45 (27%)
		FN3	791..>964	CDD:442628	28/179 (16%)
		FN3	1224..1302	CDD:238020	25/77 (32%)
		PTKc_InsR_like	1364..1652	CDD:173625	106/299 (35%)
EPHA3	NP_005224.2	EphR_LBD_A3	29..201	CDD:198449	29/169 (17%)
		FN3	<323..>543	CDD:442628	64/253 (25%)
		FN3	437..528	CDD:238020	29/99 (29%)
		EphA2_TM	555..618	CDD:464211	12/67 (18%)
		PTKc_EphR_A	616..882	CDD:270651	105/289 (36%)
		SAM_superfamily	912..974	CDD:472832
		PDZ-binding. /evidence=ECO:0000255	981..983