DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and ver-1

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_497162.2 Gene:ver-1 / 175182 WormBaseID:WBGene00006894 Length:1083 Species:Caenorhabditis elegans


Alignment Length:977 Identity:213/977 - (21%)
Similarity:351/977 - (35%) Gaps:306/977 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   908 ISSELTNAESDVKNFRTNPGRPSKVTEVVATAI-SDSKINVTWSYLDKPYGV-LTR-------YF 963
            :.|:...::.|:.|..|.|.:.:|:||.....: :|.|:..:..: |..:|. :||       .|
 Worm   154 LPSKSVFSKKDLWNELTVPCKTTKLTESKEIELYADGKLVASQDF-DPRHGFRITRKGYAAQPSF 217

  Fly   964 IKAKLINRPTRNNNRDYC---TEPL----VKAMENDLP--------------------ATTPTKK 1001
            .:.| .|:..:..:.|:.   .||:    :...|:..|                    ...|  |
 Worm   218 FECK-FNKKNKTQSVDFIISKNEPIDNEYILFWEDSFPFPHVGYNFSLTCHLVYIEPNGNAP--K 279

  Fly  1002 ISDPLAGDC-KC---------VE-----GSKKTSS-------QEYDDRKV--------QAGMEFE 1036
            :.: ||.:| :|         :|     |.|:.||       |..|..|.        :|..|.|
 Worm   280 LGE-LAFECPQCQSRLDNHLVIEKHHNVGRKRLSSAIHIKNLQLRDAGKYRCIWKKTGKARQEIE 343

  Fly  1037 NALQNFIFVPNIR---------KSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRR-------R 1085
            ::|.....:..:|         |:|.||......|:.|     ..|.|..|...||.       |
 Worm   344 HSLHVSPTIAQVRILEQSPSFLKAKAGSGSVKLYAKFA-----VYPAGNYTVTWRRTYNSIEGPR 403

  Fly  1086 DVALEPELDD--VEGSVLLRHVRSITD----------------DTD--AFFEKDDENTYKDEEDL 1130
            |..:|..|..  :|.|..: .|..|||                ||.  .|:|...|:.|.|.:.:
 Worm   404 DEIVEKGLSATFLENSESM-EVLDITDLSCNKSGKYLLSINYQDTSETIFWEVAVESDYPDVQLI 467

  Fly  1131 SSNKQFYEVFAKELPPNQTH---------------------------------FV----FE---- 1154
            ......::||..:.....||                                 ||    ||    
 Worm   468 IREPASFKVFGHQFYLLGTHLNIDCVSTSIPLVDALLEYRKENFKIFTKVSRSFVADGTFERKIS 532

  Fly  1155 -----------KLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFA---- 1204
                       |.|...|.|:..|...:|||:.|.:..| .||...:.|||..|....|.|    
 Worm   533 YQVVLTENMMLKCRVGNRVALETVHVADEIPNIKFKLAS-NKSAIYEGDTVKLTCVVPKLAGRCS 596

  Fly  1205 --------DIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPA 1261
                    .|:...:| .||:..:...:|...|   ..:|.       |.....:|..|      
 Worm   597 ITWVHRNLSILHSTEV-TEHSQLSFLYIRNATT---SASGN-------YTCVLENQASE------ 644

  Fly  1262 ADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSY--------------AKVF 1312
               |.:...::|:...:..:.|:....|..|...:. :|...|||.|              .|.|
 Worm   645 ---NFSLSTILKVEPIIAPYIVKTGFSAPTGSKLDC-NIDGRPPPEYQWFKDGTPYGTGRRLKFF 705

  Fly  1313 ----------------------------------FWLLGIGLAFLIVSLFGYVCYLHKRKVPSN- 1342
                                              |.||.| ||..|:.:.|:       |:.:. 
 Worm   706 EEDNSGIYQCLATNRAGSATNSFELKTAGRSYGIFVLLAI-LALGILVILGW-------KISTKL 762

  Fly  1343 DLHMNTEVNPFYASM----QYIPD--------DWEVLRENIIQLAPLGQGSFGMVYEGILKSFPP 1395
            ....|.::...|.|:    .::|:        ::|..::::..|.|:|.|.||:|..||||    
 Worm   763 GWKKNRDLKLLYKSLIGSENFLPNGKNQFSNFNFEFHKDSLEILEPIGSGHFGVVRRGILK---- 823

  Fly  1396 NGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCS---RGQPALVVMELMKK 1456
             |.....|:|:.:..::...:...:.|..:|.....: :|:.|:|..:   |.....::||.:..
 Worm   824 -GTKTVVAVKSSSYRSSIGFQKVIVEELKLMSAIPKHPNVLALVGAITKNLRHGELYILMEYIDG 887

  Fly  1457 GDLKSYLRAHRPEERDEAMMTY----------LNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLA 1511
            |:|:.:|:..|....||....:          .|.:..|.         :..:|.:||:||.:|.
 Worm   888 GNLRDFLQQRRNVFIDELHDNFDENIPLIRPDFNSLSTTD---------LVGIAHQIANGMEWLG 943

  Fly  1512 AKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSA 1576
            ....||.:|..|..:::...|::|.|:|:      .|..||.:.    :|||.||::...::||.
 Worm   944 NVPCVHGNLCCRKVLISKTKTIRITDYGV------GDRQRKSSS----MRWMAPEAIEHQMFSSK 998

  Fly  1577 SDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARP 1641
            |||:|||:.|:|:.||...||.....|.:|:::.:|....:||.||..|:.|||.||......||
 Worm   999 SDVWSFGICLYEIFTLGGTPYPTCVTENILKHIKNGSRNLQPEYCPSALYDLMQLCWRAPPQDRP 1063

  Fly  1642 SF 1643
            .|
 Worm  1064 KF 1065

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 14/64 (22%)
FN3 1224..1302 CDD:238020 12/77 (16%)
PTKc_InsR_like 1364..1652 CDD:173625 83/294 (28%)
ver-1NP_497162.2 IG_like 578..654 CDD:214653 17/95 (18%)
Ig strand B 582..586 CDD:409353 1/3 (33%)
Ig strand C 596..600 CDD:409353 0/3 (0%)
Ig strand E 619..623 CDD:409353 0/3 (0%)
Ig strand F 633..638 CDD:409353 1/11 (9%)
Ig strand G 647..650 CDD:409353 0/2 (0%)
Ig 663..731 CDD:472250 10/68 (15%)
Ig strand B 674..677 CDD:409565 0/2 (0%)
Ig strand C 686..690 CDD:409565 1/3 (33%)
Ig strand F 712..717 CDD:409565 0/4 (0%)
Ig strand G 725..728 CDD:409565 0/2 (0%)
PTKc 807..1073 CDD:270623 81/283 (29%)
Blue background indicates that the domain is not in the aligned region.

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