Protein Alignment InR and R09D1.12

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_496025.2
• Gene: R09D1.12 / 174501
• WormBaseID: WBGene00011168
• Length: 455
• Species: Caenorhabditis elegans
• Alignment Length: 459
• Identity: 114/459 - (24%)
• Similarity: 194/459 - (42%)
• Gaps: 89/459 - (19%)

  Fly  1275 NEGLYSFRVRANSIAGYGDFTEV-----------EHIKVE--------------------PPPSY 1308
            :||...|:| |.::..||.|..:           |.|.::                    .|.|.
 Worm    21 DEGSTMFKV-AGALFAYGIFVGIFVLICHIRRAFESINIQQYTNRGNAIRNSYVQVQTEITPSSI 84

  Fly  1309 AKVFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQ 1373
            ..|....|||.               ...|.|:..::...|..|:..:.:..|::.:.....
 Worm    85 LAVQENTLGIE---------------STNKEPTQPINERAEKLPYNPAFEIQPNNLDTFNRK--- 131

  Fly  1374 LAPLGQGSFGMVYEGI--LKSFPPNGVDR-ECAIKTVNENATDRERTNFLSEASVMKEFDTY-HV 1434
               ||:|.||::.:|:  |:....|.|.: ..|:|.:.:...:::......|..:|.....: :|
 Worm   132 ---LGKGKFGIINKGLLTLRICKTNEVVQVNVAVKKMVDPTDEKQDKLIYDEIKLMCAIGKHPNV 193

  Fly  1435 VRLLGVCSRGQPA------LVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTY 1493
            :.::|..::.:..      ..|.|.::.|||:|.||......:||  :|...|.| ..||....:
 Worm   194 LAIVGAITKKEKVSGREYNQAVSEFIEGGDLRSVLRNSPYTFQDE--ITSRERTG-GQNVDAEVF 255

  Fly  1494 GRI-----YQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYY--R 1551
            ..|     :..|.:||:||.|||:...||||||.||..|..:..::|||||:.|...:.|||  :
 Worm   256 DTISTSDLFSFAYQIANGMEYLASLPCVHRDLALRNVFVKKNKIIRIGDFGLARHNGDKDYYKVK 320

  Fly  1552 KGTKGLLPVRWMPPESLRDGV-YSSASDVFSFGVVLWEMATLAAQPYQGLSNEQ--------VLR 1607
            ...:..||:.|:.||...||. ::..:||:|:||.|:|:.:|.|.||  |...|        |:.
 Worm   321 YSPETPLPIFWLAPECFDDGTSFTEMTDVWSYGVCLFELFSLGASPY--LEEFQNFFDPIYYVVA 383

  Fly  1608 YVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQ 1672
            ::..|..:..|:.|...::..|..||:..:..||.|.....:.:     :..|..:|.:.|..||
 Worm   384 FLESGKRLSSPKYCRSDIYNFMLECWNSDAKQRPRFTKCKEFFK-----NLIKRKNFKNLETDLQ 443

  Fly  1673 HREK 1676
            ..|:
 Worm   444 TEEQ 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	10/37 (27%)
		PTKc_InsR_like	1364..1652	CDD:173625	87/313 (28%)
R09D1.12	NP_496025.2	TyrKc	127..426	CDD:197581	87/309 (28%)