DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and Kit

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001116205.1 Gene:Kit / 16590 MGIID:96677 Length:979 Species:Mus musculus


Alignment Length:510 Identity:139/510 - (27%)
Similarity:223/510 - (43%) Gaps:112/510 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1229 TP--PVDPNGEIVTYEVAYKLQKPDQVEEK--------KCIPAADFNQTAGYLIKLNEGLYSFRV 1283
            ||  |||...:.|:.....||.....::..        :|..:.|..:::.:        ::|..
Mouse   455 TPVSPVDVQVQNVSVSPFGKLVVQSSIDSSVFRHNGTVECKASNDVGKSSAF--------FNFAF 511

  Fly  1284 RANS---IAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYLHKRKVPSNDLH 1345
            :.|:   |..:..||.:             :..:::..|...:||.:..|. ||.|   |..::.
Mouse   512 KGNNKEQIQAHTLFTPL-------------LIGFVVAAGAMGIIVMVLTYK-YLQK---PMYEVQ 559

  Fly  1346 MNT--EVNP---FYASMQYIPDD--WEVLRENIIQLAPLGQGSFGMVYE----GILKSFPPNGVD 1399
            ...  |:|.   .|.....:|.|  ||..|..:.....||.|:||.|.|    |::||.....| 
Mouse   560 WKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTV- 623

  Fly  1400 RECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYL 1463
               |:|.:..:|...||...:||..|:.....: ::|.|||.|:.|.|.||:.|....|||.::|
Mouse   624 ---AVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFL 685

  Fly  1464 RAHR-------PEERDEAMMTYLNRI------------------GVTGNVQPPTYGR-------- 1495
            |..|       .||:.||.: |.|.:                  ||:..|...|..|        
Mouse   686 RRKRDSFIFSKQEEQAEAAL-YKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSY 749

  Fly  1496 ---------------------IYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFG 1539
                                 :...:.::|.|||:||:|..:||||||||.::......||.|||
Mouse   750 IERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFG 814

  Fly  1540 MTRDI-YETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLS-N 1602
            :.||| .:::|..|| ...|||:||.|||:...||:..|||:|:|:.|||:.:|.:.||.|:. :
Mouse   815 LARDIRNDSNYVVKG-NARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVD 878

  Fly  1603 EQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNS 1657
            .:..:.:.:|..|..||:.|..::.:|:.||......||:|..::..:|.|..:|
Mouse   879 SKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLIEKQISDS 933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 15/85 (18%)
PTKc_InsR_like 1364..1652 CDD:173625 108/348 (31%)
KitNP_001116205.1 ig 217..308 CDD:395002
Ig strand B 230..234 CDD:409353
Ig strand C 244..248 CDD:409353
Ig strand E 276..280 CDD:409353
Ig strand G 300..306 CDD:409353
IgI_4_SCFR 314..414 CDD:409446
Ig strand A 314..320 CDD:409446
Ig strand A' 324..329 CDD:409446
Ig strand B 332..342 CDD:409446
Ig strand C 346..353 CDD:409446
Ig strand C' 355..358 CDD:409446
Ig strand D 361..366 CDD:409446
Ig strand E 375..384 CDD:409446
Ig strand F 391..399 CDD:409446
Ig strand G 402..413 CDD:409446
Ig 429..505 CDD:409353 10/49 (20%)
Ig strand C 440..444 CDD:409353
Ig strand E 473..481 CDD:409353 2/7 (29%)
Ig strand F 491..496 CDD:409353 1/4 (25%)
PTKc_Kit 556..930 CDD:270682 114/379 (30%)
Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250 571..573 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

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