DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Kdr

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_034742.2 Gene:Kdr / 16542 MGIID:96683 Length:1345 Species:Mus musculus


Alignment Length:1463 Identity:309/1463 - (21%)
Similarity:527/1463 - (36%) Gaps:447/1463 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   623 PTGYQKSENKRMCEPCPGGKCDKECSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMD 687
            |...:.||.:.:...|.||           ||:       .|..:|    :...:..::||:...
Mouse    64 PNAQRDSEERVLVTECGGG-----------DSI-------FCKTLT----IPRVVGNDTGAYKCS 106

  Fly   688 ELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQ 752
            .....:|      |::.|::. ..:| .|..|:::..|         .:|:.:|:        |:
Mouse   107 YRDVDIA------STVYVYVR-DYRS-PFIASVSDQHG---------IVYITENK--------NK 146

  Fly   753 TVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGS-------------- 803
            ||.|...|...:.|..||.              ::.||..|   .:|||.|              
Mouse   147 TVVIPCRGSISNLNVSLCA--------------RYPEKRFV---PDGNRISWDSEIGFTLPSYMI 194

  Fly   804 -------CGTAVLNVTLQSV-------------------------GANSAMLNVTTKVEI----- 831
                   |...:.:.|.||:                         .....:||.|.:.|:     
Mouse   195 SYAGMVFCEAKINDETYQSIMYIVVVVGYRIYDVILSPPHEIELSAGEKLVLNCTARTELNVGLD 259

  Fly   832 ----GEPQKPSNATIVFKDPRAFIGFVFYHMID--PYGNSTKSSDDPCDDRWKVSSPEKSGVMVL 890
                ..|.|..:..||.:|.:.|.|.|....:.  ...:.|||      |:.:.:....||.|:.
Mouse   260 FTWHSPPSKSHHKKIVNRDVKPFPGTVAKMFLSTLTIESVTKS------DQGEYTCVASSGRMIK 318

  Fly   891 SNLI-------PYTNYSYYVRTM---AISSE-------LTNAESDVKNFRTNPGRP--SKVTEVV 936
            .|..       |:..:...::::   .:.|:       |:....|:|.:|.  |||  |..|.:|
Mouse   319 RNRTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYPAPDIKWYRN--GRPIESNYTMIV 381

  Fly   937 ATAISDSKI------NVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMEN---- 991
            ...::..::      |.| ..|..|..:..:..:.:.::|.|.:...:     .|:..|::    
Mouse   382 GDELTIMEVTERDAGNYT-VILTNPISMEKQSHMVSLVVNVPPQIGEK-----ALISPMDSYQYG 440

  Fly   992 DLPATTPTKKISDPLAG-------DCKCVEGSKKTSS------QEYDDRKVQAGMEFENALQNFI 1043
            .:...|.|...:.||..       :..|.....:||.      :..:|  .|.|.:.|.....:.
Mouse   441 TMQTLTCTVYANPPLHHIQWYWQLEEACSYRPGQTSPYACKEWRHVED--FQGGNKIEVTKNQYA 503

  Fly  1044 FVPNIRKSKNGSSDKSDGAEGAAL-DSNAIPNGGATNPSRRRR----------DVALEPELDDVE 1097
            .:..  |:|..|:.....|..:|| ...||...|     |..|          ::.::|.....|
Mouse   504 LIEG--KNKTVSTLVIQAANVSALYKCEAINKAG-----RGERVISFHVIRGPEITVQPAAQPTE 561

  Fly  1098 GSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEV--------FAKELPPNQTHFVFE 1154
                        .::.:.....|.||::       |..:|::        ..:.|.|        
Mouse   562 ------------QESVSLLCTADRNTFE-------NLTWYKLGSQATSVHMGESLTP-------- 599

  Fly  1155 KLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIV---MDLKVDLEH 1216
                         .|:......||..|.|..|........||....:...|.|   .|.|....|
Mouse   600 -------------VCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDYVCSAQDKKTKKRH 651

  Fly  1217 ANNTESPVRVRWTPPVDPN--------GEIV----------TYEVAYKLQKPDQVEEKKCI-PAA 1262
            ....:..:..|..|.:..|        ||.:          |..:.:.......||:...: ...
Mouse   652 CLVKQLIILERMAPMITGNLENQTTTIGETIEVTCPASGNPTPHITWFKDNETLVEDSGIVLRDG 716

  Fly  1263 DFNQTAGYLIKLNEGLYSFR-------VRANS---IAGYGDFTEVEHIKVEPPPSYAKVFFWLLG 1317
            :.|.|...:.|.:.|||:.:       .||.:   |.|..:.|.:|.| :....:...:||||| 
Mouse   717 NRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEVI-ILVGTAVIAMFFWLL- 779

  Fly  1318 IGLAFLIVSL------------FGYVCYLHKRKVPSNDLHMNTEVNPFYASMQYIPDD---WEVL 1367
                 |::.|            .||:           .:.|:.:..|.....:.:|.|   ||..
Mouse   780 -----LVIVLRTVKRANEGELKTGYL-----------SIVMDPDELPLDERCERLPYDASKWEFP 828

  Fly  1368 RENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTV-----NENATDRERTNFLSEASVMK 1427
            |:.:....|||:|:||.|.|.  .:|   |:|:....|||     .|.||..|....:||..::.
Mouse   829 RDRLKLGKPLGRGAFGQVIEA--DAF---GIDKTATCKTVAVKMLKEGATHSEHRALMSELKILI 888

  Fly  1428 EFDTY-HVVRLLGVCSR-GQPALVVMELMKKGDLKSYLRAHRPE--------ERDEAMMTYLNRI 1482
            ....: :||.|||.|:: |.|.:|::|..|.|:|.:|||..|.|        .|......|:..:
Mouse   889 HIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGEL 953

  Fly  1483 GV-----------------TGNVQPPTYGRIYQ-------------------MAIEIADGMAYLA 1511
            .|                 :|.|:..:...:.:                   .:.::|.||.:||
Mouse   954 SVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLA 1018

  Fly  1512 AKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY-ETDYYRKGTKGLLPVRWMPPESLRDGVYSS 1575
            ::|.:||||||||.::::...|||.|||:.|||| :.||.||| ...||::||.||::.|.||:.
Mouse  1019 SRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG-DARLPLKWMAPETIFDRVYTI 1082

  Fly  1576 ASDVFSFGVVLWEMATLAAQPYQGLS-NEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSA 1639
            .|||:||||:|||:.:|.|.||.|:. :|:..|.:.:|..|..|:.....:::.|..|||...:.
Mouse  1083 QSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQ 1147

  Fly  1640 RPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQED 1704
            ||||.:::.:|....             :|..|...|:         :..:|:.:.|   ..:||
Mouse  1148 RPSFSELVEHLGNLL-------------QANAQQDGKD---------YIVLPMSETL---SMEED 1187

  Fly  1705 ATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLP---FSLPSG---FIASSTPDGQTVMATAFQ 1763
            :...|              |.||::.::::....|   :...:|   ::.:|....:.|....|:
Mouse  1188 SGLSL--------------PTSPVSCMEEEEVCDPKFHYDNTAGISHYLQNSKRKSRPVSVKTFE 1238

  Fly  1764 NIPAAQGDISATYVVPDADALDGDRGYEIYDPSPKCAELPTSRSGSTGGGKLSGEQHLLPRKGRQ 1828
            :||..:.::.   |:||....|.  |..:.....|..|.....|.|.||        ::|.|.|:
Mouse  1239 DIPLEEPEVK---VIPDDSQTDS--GMVLASEELKTLEDRNKLSPSFGG--------MMPSKSRE 1290

  Fly  1829 PTIMSSSMPDDVIGGSSLQPSTASAGSSNASSH 1861
                                |.||.||:..|.:
Mouse  1291 --------------------SVASEGSNQTSGY 1303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614 6/21 (29%)
Recep_L_domain 663..781 CDD:460032 21/117 (18%)
FN3 791..>964 CDD:442628 45/254 (18%)
FN3 1224..1302 CDD:238020 21/106 (20%)
PTKc_InsR_like 1364..1652 CDD:173625 113/340 (33%)
KdrNP_034742.2 Ig 226..327 CDD:472250 20/106 (19%)
Ig strand B 244..248 CDD:409353 1/3 (33%)
Ig strand C 259..263 CDD:409353 0/3 (0%)
Ig strand E 292..296 CDD:409353 0/3 (0%)
Ig strand F 306..311 CDD:409353 0/4 (0%)
Ig strand G 319..322 CDD:409353 1/2 (50%)
Ig 331..419 CDD:472250 15/90 (17%)
Ig strand B 350..354 CDD:409353 0/3 (0%)
Ig strand C 363..367 CDD:409353 2/3 (67%)
Ig strand E 383..387 CDD:409353 0/3 (0%)
Ig strand F 397..402 CDD:409353 2/5 (40%)
Ig strand G 412..415 CDD:409353 0/2 (0%)
Ig_3 549..642 CDD:464046 19/132 (14%)
I-set 665..742 CDD:400151 13/76 (17%)
Ig strand B 682..686 CDD:409353 0/3 (0%)
Ig strand C 695..699 CDD:409353 0/3 (0%)
Ig strand E 718..722 CDD:409353 1/3 (33%)
Ig strand F 732..737 CDD:409353 2/4 (50%)
VEGFR-2_TMD 757..791 CDD:375470 10/40 (25%)
PTKc_VEGFR2 824..1165 CDD:270681 113/359 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1272..1316 13/60 (22%)
Blue background indicates that the domain is not in the aligned region.

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