Protein Alignment InR and CSF1R

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_005202.2
• Gene: CSF1R / 1436
• HGNCID: 2433
• Length: 972
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 150/582 - (25%)
• Similarity: 244/582 - (41%)
• Gaps: 137/582 - (23%)

  Fly  1221 ESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGLYSFRVRA 1285
            |:.|...|.   ||..|:::.|..:|:    .|:....:...:.|||             :..||
Human   443 EAQVLQVWD---DPYPEVLSQEPFHKV----TVQSLLTVETLEHNQT-------------YECRA 487

  Fly  1286 NSIAGYGDFTEV-----EHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYLHKRK------- 1338
            ::..|.|.:..:     .|  ..||..:......:..:.:..|::.|...:.|.:|:|
Human   488 HNSVGSGSWAFIPISAGAH--THPPDEFLFTPVVVACMSIMALLLLLLLLLLYKYKQKPKYQVRW 550

  Fly  1339 --VPSNDLHMNTEVNPFYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRE 1401
              :.|.:.:..|.::|  ..:.| .:.||..|.|:.....||.|:||.|.|.............:
Human   551 KIIESYEGNSYTFIDP--TQLPY-NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLK 612

  Fly  1402 CAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYLRA 1465
            .|:|.:...|...|:...:||..:|.....: ::|.|||.|:.|.|.||:.|....|||.::||
Human   613 VAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLR- 676

  Fly  1466 HRPEERDEAMM-----------------------TYLNRIGVTGNVQPPTY-------------- 1493
                .:.|||:                       .|:.|.....:....||
Human   677 ----RKAEAMLGPSLSPGQDPEGGVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSF 737

  Fly  1494 ---------GR------IYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRD 1543
                     ||      :...:.::|.|||:||:|..:|||:||||.::.:....||||||:.||
Human   738 SEQDLDKEDGRPLELRDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARD 802

  Fly  1544 IY-ETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQG-LSNEQVL 1606
            |. :::|..|| ...|||:||.|||:.|.||:..|||:|:|::|||:.:|...||.| |.|.:..
Human   803 IMNDSNYIVKG-NARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFY 866

  Fly  1607 RYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGL 1671
            :.|.||..|.:|...|..::.:||.||....:.||:|..|.::|:.|.
Human   867 KLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSFLQEQA----------------- 914

  Fly  1672 QHREKERKERNQLDAFAAVP----------LDQDLQDREQQEDATTPLRMGDYQQNSSLDQP 1723
               :::|:||:    :..:|          ...:|::....|..|. ...||..|  .|.||
Human   915 ---QEDRRERD----YTNLPSSSRSGGSGSSSSELEEESSSEHLTC-CEQGDIAQ--PLLQP 966

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	16/82 (20%)
		PTKc_InsR_like	1364..1652	CDD:173625	108/342 (32%)
CSF1R	NP_005202.2	IG_like	28..85	CDD:214653
		Ig strand B	38..42	CDD:409353
		Ig strand C	55..58	CDD:409353
		Ig strand E	66..71	CDD:409353
		Ig strand F	81..86	CDD:409353
		Ig strand G	94..97	CDD:409353
		IgI_3_CSF-1R	203..295	CDD:409530
		Ig strand A	203..208	CDD:409530
		Ig strand A'	210..216	CDD:409530
		Ig strand B	220..228	CDD:409530
		Ig strand C	234..238	CDD:409530
		Ig strand C'	241..244	CDD:409530
		Ig strand D	248..253	CDD:409530
		Ig strand E	257..265	CDD:409530
		Ig strand F	274..282	CDD:409530
		Ig strand G	285..295	CDD:409530
		IgI_4_SCFR_like	299..400	CDD:409364
		Ig strand A	299..305	CDD:409364
		Ig strand A'	309..314	CDD:409364
		Ig strand B	317..327	CDD:409364
		Ig strand C	331..338	CDD:409364
		Ig strand C'	340..343	CDD:409364
		Ig strand D	347..352	CDD:409364
		Ig strand E	361..370	CDD:409364
		Ig strand F	377..385	CDD:409364
		Ig strand G	388..399	CDD:409364
		Ig_3	401..489	CDD:464046	14/65 (22%)
		Regulatory juxtamembrane domain	542..574		5/34 (15%)
		PTKc_CSF-1R	543..914	CDD:133237	113/379 (30%)
		Activation loop	796..818		9/22 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	918..950		5/35 (14%)