Protein Alignment InR and Flt3

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_034359.2
• Gene: Flt3 / 14255
• MGIID: 95559
• Length: 1000
• Species: Mus musculus
• Alignment Length: 999
• Identity: 228/999 - (22%)
• Similarity: 376/999 - (37%)
• Gaps: 259/999 - (25%)

  Fly   788 FEKSDVGADSN---GNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVF----K 845
            |:.|.:|...:   .|||....|:||||  ...|...:|::.::.        :|.|::|    :
Mouse   108 FKHSSLGCQPHFDLQNRGIVSMAILNVT--ETQAGEYLLHIQSEA--------ANYTVLFTVNVR 162

  Fly   846 DPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISS 910
            |.:.::      :..||....::.|               .::.:|..:|
Mouse   163 DTQLYV------LRRPYFRKMENQD---------------ALLCISEGVP--------------- 191

  Fly   911 ELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRN 975
                 |..|:....:..|.|...|..|....:.|:      |.:.:|...|..         .||
Mouse   192 -----EPTVEWVLCSSHRESCKEEGPAVVRKEEKV------LHELFGTDIRCC---------ARN 236

  Fly   976 NNRDYCTE----PLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTS-SQEYDDRKVQAGMEF 1035
            .....||:    .|.:|.::.||..  ..|:.:||...||.:..:.... :.|.:|:.::.|..|
Mouse   237 ALGRECTKLFTIDLNQAPQSTLPQL--FLKVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYF 299

  Fly  1036 ENALQN---------FIFVPNIRKSKNG----SSDK--SDGAEGAALDSNAIPNGGATNPSRRRR 1085
            |.:..:         ..||.::.::..|    ||.|  |..|....|:...|   .||:...
Mouse   300 EMSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFI---NATSSQE--- 358

  Fly  1086 DVALEPELDDVEG---SVLLR---HVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKEL 1144
                |.|:|..|.   ||..:   .:|.....:.|.|..:....    ||..|..:|.:  .|..
Mouse   359 ----EYEIDPYEKFCFSVRFKAYPRIRCTWIFSQASFPCEQRGL----EDGYSISKFCD--HKNK 413

  Fly  1145 PPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMD 1209
            |.....:.......||:  :|.:..|::  .:.|.:.|..::.||.......:...||.:|
Mouse   414 PGEYIFYAENDDAQFTK--MFTLNIRKK--PQVLANASASQASCSSDGYPLPSWTWKKCSD---- 470

  Fly  1210 LKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKL 1274
                                                  :.|:..||   ||...:|:      |.
Mouse   471 --------------------------------------KSPNCTEE---IPEGVWNK------KA 488

  Fly  1275 NEGLYSFRVRANSI----AGYGDF----------TEVEHIKVEPPPSYAKV-----FFWLLGIGL 1320
            |..::...|.::::    ||.|..          |..|.|.:..|..:..:     |:..:|:.|
Mouse   489 NRKVFGQWVSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPFIQDNISFYATIGLCL 553

  Fly  1321 AFLIVSLFGYVCYLHKRKVP-SNDLHMNTEVNP-----FYASMQYIPDD--WEVLRENIIQLAPL 1377
            .|::| |...:|:.:|::.. .:.|.|.....|     ||...:....|  ||..|||:.....|
Mouse   554 PFIVV-LIVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYVDFRDYEYDLKWEFPRENLEFGKVL 617

  Fly  1378 GQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTY-HVVRLLGVC 1441
            |.|:||.|...........||..:.|:|.:.|.|...|:...:||..:|.....: ::|.|||.|
Mouse   618 GSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGAC 682

  Fly  1442 SRGQPALVVMELMKKGDLKSYLRAHR------------------------------PEERDEAMM 1476
            :...|..::.|....|||.:|||:.|                              |..|:..:.
Mouse   683 TLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLH 747

  Fly  1477 TYLNRI-GVTGN-----------------------VQPPTYGRIYQMAIEIADGMAYLAAKKFVH 1517
            ..|::: |..||                       :...|:..:...|.::|.||.:|..|..||
Mouse   748 PPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVH 812

  Fly  1518 RDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSF 1582
            |||||||.:|.....|||.|||:.|||.....|.......|||:||.||||.:|:|:..|||:|:
Mouse   813 RDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSY 877

  Fly  1583 GVVLWEMATLAAQPYQGLSNEQVLRYVIDGGV-MERPENCPDFLHKLMQRCWHHRSSARPSFLDI 1646
            |::|||:.:|...||.|:..:.....:|..|. ||:|....:.::.:||.||...|..||||.::
Mouse   878 GILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNL 942

  Fly  1647 IAYLEPQCPNSQFKEVSFYHSEAG 1670
            .::|..|...:   |.:.|.:..|
Mouse   943 TSFLGCQLAEA---EEAMYQNMGG 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628	31/179 (17%)
		FN3	1224..1302	CDD:238020	15/91 (16%)
		PTKc_InsR_like	1364..1652	CDD:173625	106/343 (31%)
Flt3	NP_034359.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	45..67
		ig	256..346	CDD:395002	20/91 (22%)
		Ig strand B	269..273	CDD:409353	1/3 (33%)
		Ig strand C	283..287	CDD:409353	0/3 (0%)
		Ig strand E	315..318	CDD:409353	0/2 (0%)
		Ig strand F	328..333	CDD:409353	0/4 (0%)
		7tm_GPCRs	<491..>586	CDD:475119	18/95 (19%)
		Protein Kinases, catalytic domain	573..950	CDD:473864	112/376 (30%)
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250	592..598		1/5 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	968..1000