Protein Alignment InR and Ephb6

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_031706.3
• Gene: Ephb6 / 13848
• MGIID: 1096338
• Length: 1014
• Species: Mus musculus
• Alignment Length: 742
• Identity: 164/742 - (22%)
• Similarity: 284/742 - (38%)
• Gaps: 198/742 - (26%)

  Fly   970 NRPTRNNNR-DYCTEPLVKAMENDLPAT-TPTKKIS-DPLAGDCKCVEGSKKTSSQEYDDRKVQA 1031
            ::|.|.:.. ..|.|...||:..::|.: .|.:..| ||.|..|.|::|..:.||..
Mouse   300 HQPARGDKLCQACPEGSYKALAGNVPCSPCPARSHSPDPAAPVCPCLQGFYRASSDP-------- 356

  Fly  1032 GMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDV 1096
                                                     |....|.|....|::..|     |
Mouse   357 -----------------------------------------PEAPCTGPPSAPRELWFE-----V 375

  Fly  1097 EGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQ-FYEVFAKEL-----PP--------- 1146
            :||.|:.|                   ::..::|..... .:.|..||.     |.
Mouse   376 QGSALMLH-------------------WRLPQELGGRGDLLFNVVCKECGGHGEPSSGGMCRRCR 421

  Fly  1147 NQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMD-- 1209
            ::.|| ..:.|..|...:.|...|..:|                  .:.:.......:::..|
Mouse   422 DEVHF-DPRQRGLTESRVLVGGLRAHVP------------------YILEVQAVNGVSELSPDPP 467

  Fly  1210 ----LKVDLEH-----------ANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCI 1259
                :.|...|           .:...:.:.|.|..|...||.|:.|::.|.    ||.|::
Mouse   468 QAAAINVSTSHEVPSAVPVMHQVSRAANSITVSWPQPEQTNGNILDYQLRYY----DQAEDE--- 525

  Fly  1260 PAADFNQTA----GYLIKLNEG-LYSFRVRANSIAGYGDFTEVEHIKVEP--------PPSYAKV 1311
             :..|..|:    ..:.:|:.| :|.|:|||.:.||:|.:....:.:..|        |...:.|
Mouse   526 -SHSFTMTSETNTATVTRLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPEKLSLV 589

  Fly  1312 FFWLLGIGLAFLIVSLFGY--VCYLHKRKVPSNDLHMNTEVNP-----FYASMQYIPDDWEVLRE 1369
            ...:|| .||||:::....  |.:..||:.......:....:|     :|.......|..:.:||
Mouse   590 IGSILG-ALAFLLLAAITVLAVIFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYDDPCQAIRE 653

  Fly  1370 NIIQLAP--------LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVM 1426
            ...::.|        :|.||||.|..|.|:  |....::..||:.:.....:..:..||..|:::
Mouse   654 LAREVDPTYIKIEEVIGAGSFGEVRRGRLQ--PRGRREQAVAIQALWAGGAESLKMTFLGRAALL 716

  Fly  1427 KEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPP 1491
            .:|...:::||.||.::.:|.:|:.|||:.|.|.|:||               .|.|...::|
Mouse   717 GQFQHPNILRLEGVVTKSRPVMVLTELMELGPLDSFLR---------------QREGQFSSLQ-- 764

  Fly  1492 TYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKG 1556
                :..|...:|..|.||::..||||.|:||:.:|...|..|:...|         :..:|:..
Mouse   765 ----LVAMQRGVAAAMQYLSSFAFVHRALSARSVLVNSHLVCKVARLG---------HSPQGSSS 816

  Fly  1557 LLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENC 1621
            ||  ||..||.:..|.|:::|||:|||:::||:.:...:||..::.::||..:.....:..|..|
Mouse   817 LL--RWAAPEVITHGKYTTSSDVWSFGILMWEVMSYGERPYWDMNEQEVLNAIEQEFRLPPPPGC 879

  Fly  1622 PDFLHKLMQRCWHHRSSARPSFLDIIA 1648
            |..||.||...|....:.||.|..::|
Mouse   880 PPGLHLLMLDTWQKDRARRPHFDQLVA 906

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	23/82 (28%)
		PTKc_InsR_like	1364..1652	CDD:173625	84/293 (29%)
Ephb6	NP_031706.3	EphR_LBD_B6	34..226	CDD:198443
		Ephrin_rec_like	305..340	CDD:429604	9/34 (26%)
		fn3	366..464	CDD:394996	19/140 (14%)
		fn3	482..564	CDD:394996	23/89 (26%)
		EphA2_TM	605..660	CDD:464211	8/54 (15%)
		Protein Kinases, catalytic domain	658..912	CDD:473864	82/283 (29%)
		SAM_EPH-B6	938..1006	CDD:188954
		PDZ-binding. /evidence=ECO:0000255	1012..1014