Protein Alignment InR and Ephb3

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_034273.1
• Gene: Ephb3 / 13845
• MGIID: 104770
• Length: 993
• Species: Mus musculus
• Alignment Length: 814
• Identity: 200/814 - (24%)
• Similarity: 313/814 - (38%)
• Gaps: 220/814 - (27%)

  Fly   981 CTEPLVKAMENDLPA--TTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQN-- 1041
            |.....||.:.:.|.  ..|..:.:.|.|..|.|.....:..|...|.............:.|
Mouse   279 CPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVN 343

  Fly  1042 ---FIFVPNIRKSKNGSSD--------KSDGAEGAALDSNAIPNGGATNPSRRRRDVALEP-ELD 1094
               .|...:..:...|..|        |..|:.||         ||....||...:|...| :|.
Mouse   344 ETSLILEWSEPRDLGGRDDLLYNVICKKCRGSSGA---------GGPATCSRCDDNVEFVPRQLG 399

  Fly  1095 DVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFA-------KELPPNQTHFV 1152
            ..|..|.:.|:                        |:..:..:||.|       ..|||
Mouse   400 LTERRVHISHL------------------------LAHTRYTFEVQAVNGVSGKSPLPP------ 434

  Fly  1153 FEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHA 1217
                    |||...:...:..|||                                   |...|.
Mouse   435 --------RYAAVNITTNQAAPSE-----------------------------------VPTLHL 456

  Fly  1218 NNTE-SPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGL--- 1278
            :::. |.:.:.|.||..|||.|:.||:.|       .|:.|.|.:...:|.....:   :||
Mouse   457 HSSSGSSLTLSWAPPERPNGVILDYEMKY-------FEKSKGIASTVTSQKNSVQL---DGLQPD 511

  Fly  1279 --YSFRVRANSIAGYGDFTE-------------VEHIKVEPPPSYAKVFFWLLG---IGLAFL-I 1324
              |..:|||.::||||.::.             .:.::.:.|        .::|   .|..|: :
Mouse   512 ARYVVQVRARTVAGYGQYSHPAEFETTSERGSGAQQLQEQLP--------LIVGSTVAGFVFMVV 568

  Fly  1325 VSLFGYVCYLHKRKVPSNDL----------HMNTEVNPFYASMQYIPDDWEVLRE-------NII 1372
            |.:...||...:|..|..:.          .|...::||     ...|..|.:||       :.:
Mouse   569 VVVIALVCLRKQRHGPDAEYTEKLQQYIAPGMKVYIDPF-----TYEDPNEAVREFAKEIDVSCV 628

  Fly  1373 QLAP-LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVR 1436
            ::.. :|.|.||.|..|.||.  |...:...||||:....|:|:|.:||||||:|.:||..:::|
Mouse   629 KIEEVIGAGEFGEVCRGRLKL--PGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIR 691

  Fly  1437 LLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAI 1501
            |.||.::.:|.:::.|.|:...|.|:||.      ::...|.:..:|               |..
Mouse   692 LEGVVTKSRPVMILTEFMENCALDSFLRL------NDGQFTVIQLVG---------------MLR 735

  Fly  1502 EIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETD----YYRKGTKGLLPVRW 1562
            .||.||.||:...:|||||||||.:|..:|..|:.|||::| ..|.|    .|.....|.:|:||
Mouse   736 GIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSR-FLEDDPSDPTYTSSLGGKIPIRW 799

  Fly  1563 MPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHK 1627
            ..||::....::|||||:|:|:|:||:.:...:||..:||:.|:..|.....:..|.:||..||:
Mouse   800 TAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQ 864

  Fly  1628 LMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPL 1692
            ||..||....:.||.|..|:..|:....|:...:|:                      |.|...:
Mouse   865 LMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVT----------------------ASAPSGM 907

  Fly  1693 DQDLQDREQQEDATTPLRMGDYQQNSSLDQPPES 1726
            .|.|.|| ...|.||...:||:.....:.:..||
Mouse   908 SQPLLDR-TVPDYTTFTTVGDWLDAIKMGRYKES 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	24/95 (25%)
		PTKc_InsR_like	1364..1652	CDD:173625	103/299 (34%)
Ephb3	NP_034273.1	EphR_LBD_B3	31..203	CDD:198446
		Ephrin_rec_like	264..308	CDD:429604	6/28 (21%)
		fn3	333..431	CDD:394996	22/130 (17%)
		FN3	<468..537	CDD:238020	24/78 (31%)
		EphA2_TM	555..625	CDD:464211	15/74 (20%)
		PTKc_EphR_B	623..891	CDD:173638	100/291 (34%)
		SAM_superfamily	917..985	CDD:472832	7/24 (29%)
		PDZ-binding. /evidence=ECO:0000255	991..993