Protein Alignment InR and Ephb2

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_006538597.1
• Gene: Ephb2 / 13844
• MGIID: 99611
• Length: 988
• Species: Mus musculus
• Alignment Length: 1211
• Identity: 259/1211 - (21%)
• Similarity: 424/1211 - (35%)
• Gaps: 423/1211 - (34%)

  Fly   619 ITHCPTGYQKSENKRMCEPCPGGKCDKECSSGLIDSLERAREFHGCTIITGTEPLTISIK--RES 681
            :.|.|:|:::                   .||..:::...|.:..|.:...::...:..|  |..
Mouse    36 MVHPPSGWEE-------------------VSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRR 81

  Fly   682 GAH-VMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLD 745
            ||| :..|:|:.:                        :..:.|...|....:.:.||..: .|.|
Mouse    82 GAHRIHVEMKFSV------------------------RDCSSIPSVPGSCKETFNLYYYE-ADFD 121

  Fly   746 ELWGPNQTVFIRKGGVFFHFNPKLCVSTINQLLPMLASK--PKFFEKSDVGADSNGNRGSCGTAV 808
                                               ||:|  |.:.|...|..|         |..
Mouse   122 -----------------------------------LATKTFPNWMENPWVKVD---------TIA 142

  Fly   809 LNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPC 873
            .:.:...|.....::.:.|:|....|...:...:.|:|               ||.        |
Mouse   143 ADESFSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQD---------------YGG--------C 184

  Fly   874 DDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSE-LTNAESDVKNFRTNPGRPSKVTEVVA 937
                         :.:::..:.|......::..||..| |:.|||               |.:||
Mouse   185 -------------MSLIAVRVFYRKCPRIIQNGAIFQETLSGAES---------------TSLVA 221

  Fly   938 TAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKI 1002
            .                                       |..|   :..|.|.|:|........
Mouse   222 A---------------------------------------RGSC---IANAEEVDVPIKLYCNGD 244

  Fly  1003 SDPLA--GDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAEGA 1065
            .:.|.  |.|.|                 :||.|   |::|...   .|...:|:...:.|.|..
Mouse   245 GEWLVPIGRCMC-----------------KAGFE---AVENGTV---CRGCPSGTFKANQGDEAC 286

  Fly  1066 A---LDSNAIPNGGATNPSRR----RRDVALEP------ELDDVEGSVLLRHVRSITDDTDAFFE 1117
            .   ::|.. .:.||||...|    |.|  |:|      .:.....:|:     |..::|....|
Mouse   287 THCPINSRT-TSEGATNCVCRNGYYRAD--LDPLDMPCTTIPSAPQAVI-----SSVNETSLMLE 343

  Fly  1118 KDDENTYKDEEDLSSNKQFYEVFAK----------------ELPPNQTH------FVFEKLRHFT 1160
            ..........|||     .|.:..|                :..|.|..      ::.:.|.| |
Mouse   344 WTPPRDSGGREDL-----VYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAH-T 402

  Fly  1161 RYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVR 1225
            :|...:.|         :...:.:......:.:|..||.:...:.:.:     :...:.|...:.
Mouse   403 QYTFEIQA---------VNGVTDQSPFSPQFASVNITTNQAAPSAVSI-----MHQVSRTVDSIT 453

  Fly  1226 VRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIK----------LNEG-LY 1279
            :.|:.|..|||.|:.||:.|        .||:  ..:::|.||   ||          |..| :|
Mouse   454 LSWSQPDQPNGVILDYELQY--------YEKQ--ELSEYNATA---IKSPTNTVTVQGLKAGAIY 505

  Fly  1280 SFRVRANSIAGYGDF---------TEVEH---IKVEPPPSYAKVFFWLLG---IGLAFLI-VSLF 1328
            .|:|||.::||||.:         ||.|:   ||.:.|        .::|   .||.||| |.:.
Mouse   506 VFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIKEKLP--------LIVGSSAAGLVFLIAVVVI 562

  Fly  1329 GYVC-------------------YLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRE----- 1369
            ..||                   |......|.    |...::||     ...|..|.:||
Mouse   563 AIVCNRRRGFERADSEYTDKLQHYTSGHMTPG----MKIYIDPF-----TYEDPNEAVREFAKEI 618

  Fly  1370 -----NIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEF 1429
                 .|.|:  :|.|.||.|..|.||.  |...:...||||:....|:::|.:||||||:|.:|
Mouse   619 DISCVKIEQV--IGAGEFGEVCSGHLKL--PGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQF 679

  Fly  1430 DTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYG 1494
            |..:|:.|.||.::..|.:::.|.|:.|.|.|:||      :::...|.:..:|
Mouse   680 DHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLR------QNDGQFTVIQLVG----------- 727

  Fly  1495 RIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR---DIYETDYYRKGTKG 1556
                |...||.||.|||...:|||||||||.:|..:|..|:.|||::|   |......|.....|
Mouse   728 ----MLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGG 788

  Fly  1557 LLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENC 1621
            .:|:||..||:::...::|||||:|:|:|:||:.:...:||..::|:.|:..:.....:..|.:|
Mouse   789 KIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDC 853

  Fly  1622 PDFLHKLMQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDA 1686
            |..||:||..||....:.||.|..|:..|:....|.                        |.|.|
Mouse   854 PSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNP------------------------NSLKA 894

  Fly  1687 FAAVP-------LDQDLQDR---EQQEDATTPLRMGDYQQN 1717
            .|.:.       ||:.:.|.   ...::....::||.|:::
Mouse   895 MAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKES 935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614	3/25 (12%)
		Recep_L_domain	663..781	CDD:460032	14/120 (12%)
		FN3	791..>964	CDD:442628	23/173 (13%)
		FN3	1224..1302	CDD:238020	31/100 (31%)
		PTKc_InsR_like	1364..1652	CDD:173625	103/300 (34%)
Ephb2	XP_006538597.1	EphR_LBD_B2	19..196	CDD:198445	38/283 (13%)
		fn3	326..421	CDD:394996	16/114 (14%)
		fn3	437..521	CDD:394996	28/101 (28%)
		EphA2_TM	545..619	CDD:464211	18/82 (22%)
		PTKc_EphR_B	618..886	CDD:173638	100/292 (34%)
		SAM_EPH-B2	912..982	CDD:188951	4/24 (17%)