Protein Alignment InR and Epha8

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_031965.2
• Gene: Epha8 / 13842
• MGIID: 109378
• Length: 1004
• Species: Mus musculus
• Alignment Length: 525
• Identity: 157/525 - (29%)
• Similarity: 242/525 - (46%)
• Gaps: 94/525 - (17%)

  Fly  1197 TTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPA 1261
            ||.:...:.:|:   :..|.|..|.  |.:.|..|..|||.|:.||:.| .:|..:::....:.|
Mouse   433 TTNQAAPSQVVV---IRQERAGQTS--VSLLWQEPEQPNGIILEYEIKY-YEKDKEMQSYSTLKA 491

  Fly  1262 ADFNQTAGYLIKLNEGL-YSFRVRANSIAGYGDFTEVEHIKV-EPPPSY-AKVFFWL---LGIGL 1320
            .....|..   .|..|. |.|:|||.:.||.|.|::...::. :|.|.| .:...|:   |..||
Mouse   492 VTTRATVS---GLKPGTRYVFQVRARTSAGCGRFSQAMEVETGKPRPRYDTRTIVWICLTLITGL 553

  Fly  1321 AFLIVSLF------GY-----------VCYLHKRKVPSNDLHMN----------------TEVNP 1352
            ..|::.|.      ||           :.|.:.:..|...|.:|                |...|
Mouse   554 VVLLLLLICKKRHCGYSKAFQDSDEEKMHYQNGQAPPPVFLPLNHPPGKFPETQFSAEPHTYEEP 618

  Fly  1353 FYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERT 1417
            ..|...: ..:.|..|.:|.::  :|.|..|.|..|.|:  .|...|...|||.:....|:|:|.
Mouse   619 GRAGRSF-TREIEASRIHIEKI--IGSGESGEVCYGRLQ--VPGQRDVPVAIKALKAGYTERQRQ 678

  Fly  1418 NFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRI 1482
            :|||||::|.:||..:::||.||.:||:.|::|.|.|:.|.|.::||.|      :...|.:..:
Mouse   679 DFLSEAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENGSLDAFLRTH------DGQFTIVQLV 737

  Fly  1483 GVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR---DI 1544
            |               |...:..||.||:...::||||||||.:|...|..|:.|||::|   |.
Mouse   738 G---------------MLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRLVCKVSDFGLSRALEDD 787

  Fly  1545 YETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYV 1609
            .|..|...|  |.:|:||..||::....:||||||:|||||:||:.....:||..::|:.|:..|
Mouse   788 PEAAYTTAG--GKIPIRWTAPEAIAFRTFSSASDVWSFGVVMWEVLAYGERPYWNMTNQDVISSV 850

  Fly  1610 IDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE---------------PQCPNSQF 1659
            .:|..:..|..||..||:||..|||...:.||.|..:::.|:               .:||...|
Mouse   851 EEGYRLPAPMGCPRALHQLMLDCWHKDRAQRPRFAHVVSVLDALVHSPESLRATATVSRCPPPAF 915

  Fly  1660 KEVSF 1664
            ....|
Mouse   916 ARSCF 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	24/78 (31%)
		PTKc_InsR_like	1364..1652	CDD:173625	105/305 (34%)
Epha8	NP_031965.2	EphR_LBD_A8	30..202	CDD:198454
		FN3	<325..>518	CDD:442628	26/93 (28%)
		FN3	439..530	CDD:238020	28/99 (28%)
		EphA2_TM	<561..631	CDD:464211	9/70 (13%)
		Mediates interaction with ANKS1A and ANKS1B. /evidence=ECO:0000269|PubMed:17875921	563..569		0/5 (0%)
		Mediates interaction with PIK3CG and required for endocytosis. /evidence=ECO:0000269|PubMed:11416136	588..643		10/57 (18%)
		Protein Kinases, catalytic domain	629..895	CDD:473864	105/292 (36%)
		SAM_EPH-A8	932..994	CDD:188949
		PDZ-binding. /evidence=ECO:0000255	1002..1004