Protein Alignment InR and Epha7

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_034271.3
• Gene: Epha7 / 13841
• MGIID: 95276
• Length: 998
• Species: Mus musculus
• Alignment Length: 1002
• Identity: 242/1002 - (24%)
• Similarity: 386/1002 - (38%)
• Gaps: 279/1002 - (27%)

  Fly   750 PNQ-----TVFIRKGG---VFFHFNPKLCVSTINQLLPMLASKPKFFE------KSDVGADSNGN 800
            |||     |.:|.||.   :|...  |..:...|.|..:|.:..:.|.      ..|.|.:...|
Mouse    79 PNQNNWLRTNWISKGNAQRIFVEL--KFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIREN 141

  Fly   801 RGSCGTAVLNVTLQSVGANSAM---------LNVTTKV-EIGEPQKPSNATIVFKDPRAFIGFVF 855
                    |.|.:.::.|:.:.         :.:.|:| ||| |.......:.|:|..|.|..|
Mouse   142 --------LYVKIDTIAADESFTQGDLGERKMKLNTEVREIG-PLSKKGFYLAFQDVGACIALV- 196

  Fly   856 YHMIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYS--YYVRTMAISSELTNAESD 918
                     |.|.....|   |.:    ...:.|..:.:..:.:|  ..||...:||....||:.
Mouse   197 ---------SVKVYYKKC---WSI----VENLAVFPDTVTGSEFSSLVEVRGTCVSSAEEEAENS 245

  Fly   919 VKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTE 983
            .:...:..|.                    |..   |.|         |.|.:.......|.| |
Mouse   246 PRMHCSAEGE--------------------WLV---PIG---------KCICKAGYQQKGDTC-E 277

  Fly   984 P----LVKAMENDLPAT-TPTKKISDPLAGD-CKCVEGSKKTSSQEYDDRKVQAGMEFENALQNF 1042
            |    ..|:...||..: .||...||..... |:|.:|..:..|    |....|.....:|.||.
Mouse   278 PCGRRFYKSSSQDLQCSRCPTHSFSDREGSSRCECEDGYYRAPS----DPPYVACTRPPSAPQNL 338

  Fly  1043 IFVPNIRKSKNGSSDKSDGAEGAALDSNAIPNGGATNPSRR---RR-------------DVALEP 1091
            ||  ||.:: ..|.:.|..|:          |||..:.:.|   :|             ::...|
Mouse   339 IF--NINQT-TVSLEWSPPAD----------NGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMP 390

  Fly  1092 ELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFY---EVFAKELPPNQTHFVF 1153
            :...:|.:.:.  |..:....:..||.:..|   ...|||.:::.:   .:...:..|:|...|.
Mouse   391 QQTGLEDNYVT--VMDLLAHANYTFEVEAVN---GVSDLSRSQRLFAAVSITTGQAAPSQVSGVM 450

  Fly  1154 EKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHAN 1218
            :                                     :.|.|.:
Mouse   451 K-------------------------------------ERVLQRS-------------------- 458

  Fly  1219 NTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEG-LYSFR 1282
                 |::.|..|..|||.|..||:.|  .:.||.|  :.........|:..:..|..| :|.|:
Mouse   459 -----VQLSWQEPEHPNGVITEYEIKY--YEKDQRE--RTYSTLKTKSTSASINNLKPGTVYVFQ 514

  Fly  1283 VRANSIAGYGDFT----------------EVEHIKVEPPPSYAKVFFWLLGI-GLAFLIVSLFGY 1330
            :||.:.||||:::                |...:..|..|   .:...::.: |...|:..:||:
Mouse   515 IRAVTAAGYGNYSPRLDVATLEEASGKMFEATAVSSEQNP---VIIIAVVAVAGTIILVFMVFGF 576

  Fly  1331 V-----C-YLHKRKVPSNDLHMNTEVNPFYASMQYI-PDDWEVLRENIIQLAP------------ 1376
            :     | |....:....:|:.:.:   |..:..|| |:.:|.....:.|.|.
Mouse   577 IIGRRHCGYSKADQEGDEELYFHFK---FPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERV 638

  Fly  1377 LGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVC 1441
            :|.|.||.|..|.||.  |...|...||||:....|:::|.:||.|||:|.:||..:||.|.||.
Mouse   639 IGAGEFGEVCSGRLKL--PGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVV 701

  Fly  1442 SRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADG 1506
            :||:|.::|:|.|:.|.|.::||.|      :...|.:..:|               |...||.|
Mouse   702 TRGKPVMIVIEFMENGALDAFLRKH------DGQFTVIQLVG---------------MLRGIAAG 745

  Fly  1507 MAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR-------DIYETDYYRKGTKGLLPVRWMP 1564
            |.|||...:|||||||||.:|..:|..|:.|||::|       .:|.|      |.|.:||||..
Mouse   746 MRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTT------TGGKIPVRWTA 804

  Fly  1565 PESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLM 1629
            ||:::...::|||||:|:|:|:||:.:...:||..:||:.|::.:.:|..:..|.:||..||:||
Mouse   805 PEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLM 869

  Fly  1630 QRCWHHRSSARPSFLDIIAYLEPQCPN 1656
            ..||....:.||.|..|:..|:....|
Mouse   870 LDCWQKDRAERPKFEQIVGILDKMIRN 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032	11/38 (29%)
		FN3	791..>964	CDD:442628	33/184 (18%)
		FN3	1224..1302	CDD:238020	25/94 (27%)
		PTKc_InsR_like	1364..1652	CDD:173625	109/306 (36%)
Epha7	NP_034271.3	EphR_LBD_A7	30..206	CDD:198453	33/150 (22%)
		FN3	<314..>549	CDD:442628	58/322 (18%)
		FN3	443..534	CDD:238020	29/156 (19%)
		EphA2_TM	565..630	CDD:464211	14/67 (21%)
		PTKc_EphR_A	628..894	CDD:270651	106/294 (36%)
		SAM_EPH-A7	919..988	CDD:188947
		PDZ-binding. /evidence=ECO:0000255	996..998