Protein Alignment InR and Epha4

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_031962.2
• Gene: Epha4 / 13838
• MGIID: 98277
• Length: 986
• Species: Mus musculus
• Alignment Length: 798
• Identity: 213/798 - (26%)
• Similarity: 329/798 - (41%)
• Gaps: 187/798 - (23%)

  Fly  1013 VEGSKKTSSQEYDDRKVQAGMEFE------NALQNFIFVPNIRKSKNG-------------SSDK 1058
            |.||...:|:|.|..|:..|.:.|      |.|.|     ...:.:||             |:|.
Mouse   229 VRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCN-----AGHEEQNGECQACKIGYYKALSTDA 288

  Fly  1059 S------------DGAEGAALDSN--AIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSIT 1109
            |            :||.....|..  ...|..|:.|..|.....|.          |:.:|
Mouse   289 SCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLN----------LISNV---- 339

  Fly  1110 DDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKELPPNQTHFVFEKLR------HFTRYAIFVVA 1168
            ::|....|..........:|:|     |.|..|:......    .|.|      |:|.....:..
Mouse   340 NETSVNLEWSSPQNTGGRQDIS-----YNVVCKKCGAGDP----SKCRPCGSGVHYTPQQNGLKT 395

  Fly  1169 CREEIPSEKLRDTSFKKSL-----CSDYD-------TVFQTTKRKKFADIVMDLKVDLEHANNTE 1221
            .|..| ::.|..|::...:     .|.|:       :|..||.:...:.|.:     ::....|.
Mouse   396 TRVSI-TDLLAHTNYTFEIWAVNGVSKYNPSPDQSVSVTVTTNQAAPSSIAL-----VQAKEVTR 454

  Fly  1222 SPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEK-KCIPAADFNQTAGYLIKLNEGLYSFRVRA 1285
            ..|.:.|..|..|||.|:.|||.|  .:.||.|.. :.:..|..|.....|..|..  |.|.|||
Mouse   455 YSVALAWLEPDRPNGVILEYEVKY--YEKDQNERSYRIVRTAARNTDIKGLNPLTS--YVFHVRA 515

  Fly  1286 NSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGL--AFLIVSLFGYVC---------------- 1332
            .:.||||||:|...:.....||.      ::|.|.  ..|:||:.|.|.
Mouse   516 RTAAGYGDFSEPLEVTTNTVPSR------IIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRS 574

  Fly  1333 -YLHKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRE-------NIIQLAP-LGQGSFGMVYEG 1388
             |...::....:.|:|..|..:.....| .|..:.:||       :.|::.. :|.|.||.|..|
Mouse   575 KYSKAKQEADEEKHLNQGVRTYVDPFTY-EDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSG 638

  Fly  1389 ILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMEL 1453
            .||  .|...:...||||:....||::|.:||||||:|.:||..:::.|.||.::.:|.:::.|.
Mouse   639 RLK--VPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEY 701

  Fly  1454 MKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHR 1518
            |:.|.|.::||      :::...|.:..:|               |...|..||.||:...:|||
Mouse   702 MENGSLDAFLR------KNDGRFTVIQLVG---------------MLRGIGSGMKYLSDMSYVHR 745

  Fly  1519 DLAARNCMVADDLTVKIGDFGMTR---DIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVF 1580
            ||||||.:|..:|..|:.||||:|   |..|..|..:|  |.:|:||..||::....::|||||:
Mouse   746 DLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRG--GKIPIRWTAPEAIAYRKFTSASDVW 808

  Fly  1581 SFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLD 1645
            |:|:|:||:.:...:||..:||:.|::.:.:|..:..|.:||..||:||..||....|.||.|..
Mouse   809 SYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQ 873

  Fly  1646 IIAYLEP--QCPNSQFKEVSFYHSEAGLQHREKERKERNQLD----AFAAVPLDQDLQDREQQED 1704
            |:..|:.  :.|||..:..|           |..|.....||    .|:||
Mouse   874 IVNMLDKLIRNPNSLKRTGS-----------ESSRPNTALLDPSSPEFSAV-------------- 913

  Fly  1705 ATTPLRMGDYQQNSSLDQ 1722
                :.:||:.|...:|:
Mouse   914 ----VSVGDWLQAIKMDR 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	30/78 (38%)
		PTKc_InsR_like	1364..1652	CDD:173625	104/298 (35%)
Epha4	NP_031962.2	EphR_LBD_A4	30..203	CDD:198450
		FN3	<323..>547	CDD:442628	61/262 (23%)
		FN3	441..532	CDD:238020	32/99 (32%)
		EphA2_TM	562..618	CDD:464211	8/56 (14%)
		PTKc_EphR_A	616..882	CDD:270651	102/290 (35%)
		SAM_EPH-A4	911..981	CDD:188944	6/35 (17%)
		PDZ-binding. /evidence=ECO:0000255	984..986