Protein Alignment InR and Epha3

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_034270.1
• Gene: Epha3 / 13837
• MGIID: 99612
• Length: 984
• Species: Mus musculus
• Alignment Length: 1102
• Identity: 264/1102 - (23%)
• Similarity: 413/1102 - (37%)
• Gaps: 324/1102 - (29%)

  Fly   641 GKCDKECSS----------GLIDSLERAREF-------HGCTIITGTEPLTISIKRESGAHVMDE 688
            |.|...||.          .|:||.....|.       ||...|:|.:.....|:.....:|||.
Mouse    12 GCCVLSCSGELSPQPSNEVNLLDSKTIQGELGWISYPSHGWEEISGVDEHYTPIRTYQVCNVMDH 76

  Fly   689 LKYGLAAVHKIQSSLMVHLTYGLK-SLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQ 752
            .:......:.:..:....:...|| :|:...|:..:.|   ...:.:.||.:::.|
Mouse    77 SQNNWLRTNWVPRNSAQKIYVELKFTLRDCNSIPLVLG---TCKETFNLYYMESDD--------- 129

  Fly   753 TVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAV--LNVTLQS 815
                 ..||.|.                   :.:|.:...:.||.:..:...|..:  ||..::.
Mouse   130 -----DHGVKFR-------------------EHQFTKIDTIAADESFTQMDLGDRILKLNTEIRE 170

  Fly   816 VGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGFVFYHMIDPYGNSTKSSDDPCDDRWKVS 880
            ||                |.......:.|:|..|.:..|
Mouse   171 VG----------------PVNKKGFYLAFQDVGACVALV-------------------------- 193

  Fly   881 SPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAESDVKNFRTNPGRPSKVTEVVATAISDSKI 945
                 .|.|.....|:|     |:.:|:..:            |.|.....:.||..:.:::||.
Mouse   194 -----SVRVYFKKCPFT-----VKNLAMFPD------------TVPMDSQSLVEVRGSCVNNSKE 236

  Fly   946 NVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCT---EPLVKAMENDLPATTPTKKISDPLA 1007
            .      |.|                      |.||:   |.||                  |:
Mouse   237 E------DPP----------------------RMYCSTEGEWLV------------------PI- 254

  Fly  1008 GDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFV---PNIRKSKNG----------SSDKS 1059
            |.|.|..|        |::|             .||..   |...|:.:|          ||.:.
Mouse   255 GKCTCNAG--------YEER-------------GFICQACRPGFYKASDGAAKCAKCPPHSSTQE 298

  Fly  1060 DGAEGAALDSNAI------PNGGATNPSRRRRDVALEPELDDV-EGSVLLRHVRSITDDT----D 1113
            ||:.....::|..      |:...|.|....|:|     :.:: |.||:|..  |...||    |
Mouse   299 DGSMNCRCENNYFRAEKDPPSMACTRPPSAPRNV-----ISNINETSVILDW--SWPLDTGGRKD 356

  Fly  1114 AFF----EKDDENTYKDEEDLSSNKQFYEVFAKELP-----PNQTHFVFEKLRHFTRYAIFVVAC 1169
            ..|    :|...|. :..|..|.|.:|       ||     .|.|..|.:.|.| |.|...:
Mouse   357 ITFNIICKKCGWNV-RQCEPCSPNVRF-------LPRQLGLTNTTVTVTDLLAH-TNYTFEI--- 409

  Fly  1170 REEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDP 1234
                  :.:...|...|....|..|..||.:.. ...||.:|.|....|:    :.:.|..|..|
Mouse   410 ------DAVNGVSELSSPPRQYAAVSITTNQAA-PSPVMTIKKDRTSRNS----ISLSWQEPEHP 463

  Fly  1235 NGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEGLYSFRVRANSIAGYGDFTEVEH 1299
            ||.|:.|||.| .:|.:|......:.|...|.|...|  ..:..|.|::||.:.||||  |....
Mouse   464 NGIILDYEVKY-YEKQEQETSYTILRARGTNVTISSL--KPDTTYVFQIRARTAAGYG--TNSRK 523

  Fly  1300 IKVEPPP-------SYAKVFFWLLGIGLAFLIVSLFGYV-----CYLHKRKVPSND--LH----- 1345
            .:.|..|       ..:.|....:...:|.:::::..||     |..||.|..:.:  ||
Mouse   524 FEFETSPDSFSISGENSHVVMIAISAAVAIIVLTVVTYVLVGRFCGYHKSKHSAEEKRLHFGNGH 588

  Fly  1346 -----MNTEVNPFYASMQYIPDDWEVLRE--------NIIQLAPLGQGSFGMVYEGILKSFPPNG 1397
                 :.|.|:|     ....|..:.:.|        ||.....:|.|.||.|..|.||.  |:.
Mouse   589 LKLPGLRTYVDP-----HTYEDPTQAVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKL--PSK 646

  Fly  1398 VDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSY 1462
            .:...||||:....|:::|.:||.|||:|.:||..:::||.||.::.:|.::|.|.|:.|.|.|:
Mouse   647 KEISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVMIVTEYMENGSLDSF 711

  Fly  1463 LRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMV 1527
            ||.|      :|..|.:..:|               |...||.||.||:...:|||||||||.::
Mouse   712 LRKH------DAQFTVIQLVG---------------MLRGIASGMKYLSDMGYVHRDLAARNILI 755

  Fly  1528 ADDLTVKIGDFGMTR---DIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEM 1589
            ..:|..|:.|||::|   |..|..|..:|  |.:|:||..||::....::|||||:|:|:||||:
Mouse   756 NSNLVCKVSDFGLSRVLEDDPEAAYTTRG--GKIPIRWTSPEAIAYRKFTSASDVWSYGIVLWEV 818

  Fly  1590 ATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE 1651
            .:...:||..:||:.|::.|.:|..:..|.:||..|::||..||....:.||.|..|::.|:
Mouse   819 MSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKDRNNRPKFEQIVSILD 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614	2/3 (67%)
		Recep_L_domain	663..781	CDD:460032	18/118 (15%)
		FN3	791..>964	CDD:442628	26/174 (15%)
		FN3	1224..1302	CDD:238020	25/77 (32%)
		PTKc_InsR_like	1364..1652	CDD:173625	106/299 (35%)
Epha3	NP_034270.1	EphR_LBD_A3	29..201	CDD:198449	38/254 (15%)
		FN3	<323..>516	CDD:442628	59/225 (26%)
		FN3	437..528	CDD:238020	30/99 (30%)
		EphA2_TM	<566..619	CDD:464211	11/57 (19%)
		PTKc_EphR_A	617..883	CDD:270651	105/289 (36%)
		SAM_EPH-A3	913..975	CDD:188943
		PDZ-binding. /evidence=ECO:0000255	982..984