DRSC/TRiP Functional Genomics Resources

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Protein Alignment InR and Epha2

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_034269.2 Gene:Epha2 / 13836 MGIID:95278 Length:977 Species:Mus musculus


Alignment Length:497 Identity:151/497 - (30%)
Similarity:242/497 - (48%) Gaps:107/497 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  1211 KVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFN--QTAGYLIK 1273
            ||.||..:.|.  :.|.|:.||.....:..|||.|: :|.|         |..:|  :|.|:.:.
Mouse   442 KVRLEDRSTTS--LSVTWSIPVSQQSRVWKYEVTYR-KKGD---------ANSYNVRRTEGFSVT 494

  Fly  1274 LN----EGLYSFRVRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLLG---IGLAFLIVSLFGYV 1331
            |:    :..|..:|:|.:..|.|..::|...:.......|.:.  ::|   :|:..|:| |.|..
Mouse   495 LDDLAPDTTYLVQVQALTQEGQGAGSKVHEFQTLSTEGSANMA--VIGGVAVGVVLLLV-LAGVG 556

  Fly  1332 CYLHKR------KVPSND----------------------------LHMNTEVNPFYASMQYIPD 1362
            .::|:|      :..|.|                            |...||::|...:.|.:  
Mouse   557 LFIHRRRRNLRARQSSEDVRFSKSEQLKPLKTYVDPHTYEDPNQAVLKFTTEIHPSCVARQKV-- 619

  Fly  1363 DWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRE--CAIKTVNENATDRERTNFLSEASV 1425
                          :|.|.||.||:|.||:   :...:|  .||||:....|:::|.:||||||:
Mouse   620 --------------IGAGEFGEVYKGTLKA---SSGKKEIPVAIKTLKAGYTEKQRVDFLSEASI 667

  Fly  1426 MKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQP 1490
            |.:|..::::||.||.|:.:|.:::.|.|:.|.|..:||     |:| ...:.|..:|       
Mouse   668 MGQFSHHNIIRLEGVVSKYKPMMIITEYMENGALDKFLR-----EKD-GEFSVLQLVG------- 719

  Fly  1491 PTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTR---DIYETDYYRK 1552
                    |...||.||.|||...:|||||||||.:|..:|..|:.|||::|   |..|..|...
Mouse   720 --------MLRGIASGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTS 776

  Fly  1553 GTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMER 1617
            |  |.:|:||..||::....::|||||:|:|:|:||:.|...:||..|||.:|::.:.||..:..
Mouse   777 G--GKIPIRWTAPEAISYRKFTSASDVWSYGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPT 839

  Fly  1618 PENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLEP--QCPNS 1657
            |.:||..:::||.:||....|.||.|.||::.|:.  :.|:|
Mouse   840 PMDCPSAIYQLMMQCWQQERSRRPKFADIVSILDKLIRAPDS 881

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628
FN3 1224..1302 CDD:238020 21/83 (25%)
PTKc_InsR_like 1364..1652 CDD:173625 107/292 (37%)
Epha2NP_034269.2 Mediates interaction with CLDN4. /evidence=ECO:0000250 1..205
EphR_LBD_A2 27..200 CDD:198448
fn3 331..425 CDD:394996
fn3 439..520 CDD:394996 25/89 (28%)
EphA2_TM <570..611 CDD:464211 5/40 (13%)
Mediates interaction with ARHGEF16. /evidence=ECO:0000250 607..907 113/317 (36%)
Protein Kinases, catalytic domain 608..876 CDD:473864 110/309 (36%)
Negatively regulates interaction with ARHGEF16. /evidence=ECO:0000250 887..977
SAM_EPH-A2 903..972 CDD:188942
PDZ-binding. /evidence=ECO:0000255 975..977
Blue background indicates that the domain is not in the aligned region.

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