DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and Csf1r

DIOPT Version :10

Sequence 1:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:NP_001032948.2 Gene:Csf1r / 12978 MGIID:1339758 Length:977 Species:Mus musculus


Alignment Length:959 Identity:225/959 - (23%)
Similarity:351/959 - (36%) Gaps:270/959 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   926 PGRPSKVTE----VVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINR-PTRNNNRDY-CTEP 984
            |..|..|.|    |....:|:.  :|.|.....||..|......:.|..| .|..|...| ||| 
Mouse    25 PSGPELVVEPGETVTLRCVSNG--SVEWDGPISPYWTLDPESPGSTLTTRNATFKNTGTYRCTE- 86

  Fly   985 LVKAMENDLP-ATTPTKKISDP------LAGDCKCVEGSK--------------KTSSQEYDDRK 1028
                :|:.:. :||....:.||      ||.:...|||.:              ..|......|:
Mouse    87 ----LEDPMAGSTTIHLYVKDPAHSWNLLAQEVTVVEGQEAVLPCLITDPALKDSVSLMREGGRQ 147

  Fly  1029 V-QAGMEFENALQNFIFVPNIRKSK-------------NGSSDKSDG------------------ 1061
            | :..:.|.:..:.||    |||:|             ||....|.|                  
Mouse   148 VLRKTVYFFSPWRGFI----IRKAKVLDSNTYVCKTMVNGRESTSTGIWLKVNRVHPEPPQIKLE 208

  Fly  1062 --------AEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSIT----DDTDA 1114
                    .|.|.:..:|.......|...:|.|..||..|:........:.||:::    |..||
Mouse   209 PSKLVRIRGEAAQIVCSATNAEVGFNVILKRGDTKLEIPLNSDFQDNYYKKVRALSLNAVDFQDA 273

  Fly  1115 ----FFEKDD-------------ENTYKDEEDLSSNKQFYE-----------VFAKELPPNQTHF 1151
                ....:|             |:.|.   :|:|.:...:           |.|...|..| |:
Mouse   274 GIYSCVASNDVGTRTATMNFQVVESAYL---NLTSEQSLLQEVSVGDSLILTVHADAYPSIQ-HY 334

  Fly  1152 -------VFE---KLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDY-----------DTVF 1195
                   .||   ||...|:.||:..       :.||.....|.|....|           :..|
Mouse   335 NWTYLGPFFEDQRKLEFITQRAIYRY-------TFKLFLNRVKASEAGQYFLMAQNKAGWNNLTF 392

  Fly  1196 QTTKRKK----------------FADIV---------MDLKVDLEHANNTESPVRVRWTPPVDPN 1235
            :.|.|..                |.|:.         |:.:...:..:..:: ::| |.   |.:
Mouse   393 ELTLRYPPEVSVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQA-LQV-WN---DTH 452

  Fly  1236 GEIVTYEVAYKLQKP-DQVEEKKCIPAADFNQTAGYLIKLNE--GLYSFRVRANSIAGYGDFTEV 1297
            .|:::       ||| |:|..:..:|.........|..|.:.  |..|...||.|:   |...::
Mouse   453 PEVLS-------QKPFDKVIIQSQLPIGTLKHNMTYFCKTHNSVGNSSQYFRAVSL---GQSKQL 507

  Fly  1298 EHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYLHKRK---------VPSNDLHMNTEVNPF 1353
            ....:..|...|       .:.:..|:|.|...:.|.:|:|         :...:.:..|.::| 
Mouse   508 PDESLFTPVVVA-------CMSVMSLLVLLLLLLLYKYKQKPKYQVRWKIIERYEGNSYTFIDP- 564

  Fly  1354 YASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTN 1418
             ..:.| .:.||..|.|:.....||.|:||.|.|.............:.|:|.:...|...|:..
Mouse   565 -TQLPY-NEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEA 627

  Fly  1419 FLSEASVMKEFDTY-HVVRLLGVCSRGQPALVVMELMKKGDLKSYLR---------AHRPEERDE 1473
            .:||..:|.....: ::|.|||.|:.|.|.||:.|....|||.::||         :..|.:..|
Mouse   628 LMSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDSE 692

  Fly  1474 AMMTYLN---------------RIGVTGNVQ-----------------------PPTYGRIYQMA 1500
            ...:|.|               ..||...|:                       |.....:...:
Mouse   693 GDSSYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFS 757

  Fly  1501 IEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIY-ETDYYRKGTKGLLPVRWMP 1564
            .::|.|||:||:|..:|||:||||.::......||||||:.|||. :::|..|| ...|||:||.
Mouse   758 SQVAQGMAFLASKNCIHRDVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKG-NARLPVKWMA 821

  Fly  1565 PESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQG-LSNEQVLRYVIDGGVMERPENCPDFLHKL 1628
            |||:.|.||:..|||:|:|::|||:.:|...||.| |.|.:..:.|.||..|.:|...|..::.:
Mouse   822 PESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSI 886

  Fly  1629 MQRCWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKE 1677
            ||.||....:.||:|..|...|:.|               |.|:.|:::
Mouse   887 MQSCWDLEPTRRPTFQQICFLLQEQ---------------ARLERRDQD 920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032
Furin-like 510..645 CDD:395614
Recep_L_domain 663..781 CDD:460032
FN3 791..>964 CDD:442628 11/41 (27%)
FN3 1224..1302 CDD:238020 18/80 (23%)
PTKc_InsR_like 1364..1652 CDD:173625 107/337 (32%)
Csf1rNP_001032948.2 IG_like 28..101 CDD:214653 21/79 (27%)
Ig strand B 38..42 CDD:409353 1/3 (33%)
Ig strand E 67..71 CDD:409353 1/3 (33%)
Ig strand F 81..86 CDD:409353 2/4 (50%)
IG_like 113..195 CDD:214653 17/85 (20%)
Ig 203..295 CDD:472250 15/91 (16%)
Ig strand B 220..224 CDD:409353 1/3 (33%)
Ig strand C 234..238 CDD:409353 1/3 (33%)
Ig strand E 259..263 CDD:409353 2/3 (67%)
Ig strand F 275..280 CDD:409353 0/4 (0%)
Ig strand G 288..291 CDD:409353 0/2 (0%)
Ig 299..398 CDD:472250 22/109 (20%)
Ig strand B 319..323 CDD:409353 0/3 (0%)
Ig strand C 333..337 CDD:409353 1/3 (33%)
Ig strand E 362..366 CDD:409353 2/3 (67%)
Ig strand F 376..381 CDD:409353 1/4 (25%)
Ig strand G 389..392 CDD:409353 0/2 (0%)
Ig_3 399..487 CDD:464046 15/99 (15%)
Regulatory juxtamembrane domain. /evidence=ECO:0000250 540..572 4/34 (12%)
PTKc_CSF-1R 541..913 CDD:133237 112/390 (29%)
Activation loop. /evidence=ECO:0000250 794..816 9/22 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 921..957 225/959 (23%)
Blue background indicates that the domain is not in the aligned region.

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