Protein Alignment InR and Alk

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_031465.2
• Gene: Alk / 11682
• MGIID: 103305
• Length: 1621
• Species: Mus musculus
• Alignment Length: 599
• Identity: 174/599 - (29%)
• Similarity: 276/599 - (46%)
• Gaps: 113/599 - (18%)

  Fly  1302 VEPPPSYAKVFFWLLGIGLAFLIVSL---FGYVCYLHKRK----------VPSNDLHMN------ 1347
            |.|.|........:|.:..:.|:.:|   |..:..:::||          :.|.:..::
Mouse  1027 VSPTPEPHLPLSLILSVVTSALVAALVLAFSGIMIVYRRKHQELQAMQMELQSPEYKLSKLRTST 1091

  Fly  1348 --TEVNP---FYASMQYIPDDWEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTV 1407
              |:.||   |......|.|..||.|:||..:..||.|:||.||||.:...|.:....:.|:||:
Mouse  1092 IMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFGEVYEGQVSGMPNDPSPLQVAVKTL 1156

  Fly  1408 NENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERD 1472
            .|..::::..:||.||.::.:|:..::||.:||..:..|..:::|||..|||||:||..||....
Mouse  1157 PEVCSEQDELDFLMEALIISKFNHQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQ 1221

  Fly  1473 EAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLT----- 1532
            ...:..|:               :..:|.:||.|..||....|:|||:|||||:    ||
Mouse  1222 PTSLAMLD---------------LLHVARDIACGCQYLEENHFIHRDIAARNCL----LTCPGAG 1267

  Fly  1533 --VKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQ 1595
              .|||||||.||||...|||||...:|||:|||||:..:|:::|.:|.:||||:|||:.:|...
Mouse  1268 RIAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYM 1332

  Fly  1596 PYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE-----PQCP 1655
            ||...||::||.:|..||.|:.|:|||..::::|.:||.|:...||:|..|:..:|     |...
Mouse  1333 PYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRPNFAIILERIEYCTQDPDVI 1397

  Fly  1656 NSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQEDATTPLRMGDYQQNSSL 1720
            |:...      .|.|....|:|:......|.....||....|..:.:|.:..|..........|:
Mouse  1398 NTALP------IEYGPVVEEEEKVPMRPKDPEGMPPLLVSPQPAKHEEASAAPQPAALTAPGPSV 1456

  Fly  1721 DQPPESPIAMVDDQGSHLPFSLPSGFIASSTPD-GQTVMATAFQNIPAAQGDISATYVVPDADAL 1784
            .:||.:        |:.......:|.:.....| |...||.:..|.|            |:....
Mouse  1457 KKPPGA--------GAGAGAGAGAGPVPRGAADRGHVNMAFSQPNPP------------PELHKG 1501

  Fly  1785 DGDRG--YEIYDPS---------------PKCAELPTSRSGSTGGGKL---SGEQHLLPRKGR-- 1827
            .|.|.  ..:::|:               |..|| |.:|:|:..||..   :|     ||:..
Mouse  1502 PGSRNKPTSLWNPTYGSWFTEKPAKKTHPPPGAE-PQARAGAAEGGWTGPGAG-----PRRAEAA 1560

  Fly  1828 ---QPTIMSSSMPD 1838
               :|:.:|::|.:
Mouse  1561 LLLEPSALSATMKE 1574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	174/599 (29%)
		PTKc_InsR_like	1364..1652	CDD:173625	117/299 (39%)
Alk	NP_031465.2	Heparin-binding region. /evidence=ECO:0000250|UniProtKB:Q9UM73	48..70
		MAM	270..428	CDD:99706
		LDLa	445..471	CDD:197566
		MAM	484..639	CDD:459878
		EGF-like. /evidence=ECO:0000250|UniProtKB:Q9UM73	991..1029		1/1 (100%)
		FXa_inhibition	991..1025	CDD:464251
		PTKc_ALK_LTK	1113..1389	CDD:270632	116/294 (39%)
		PHA03247	<1374..1580	CDD:223021	46/233 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1412..1556		32/169 (19%)