Protein Alignment InR and ephb4

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_031755496.1
• Gene: ephb4 / 100497297
• XenbaseID: XB-GENE-5881604
• Length: 945
• Species: Xenopus tropicalis
• Alignment Length: 1194
• Identity: 275/1194 - (23%)
• Similarity: 428/1194 - (35%)
• Gaps: 381/1194 - (31%)

  Fly   619 ITHCPTGYQKSENKRMCEPCPGGKCDKECSSGLIDSLERAREFHGCTIITGTEPLTISIKRESGA 683
            :|...|..:.|:.|....|...|:.|:  .|||.|.....|.:..|                 .|
 Frog    18 VTLMNTKLETSDLKWTSYPKVDGQWDE--MSGLDDEGTPVRTYEIC-----------------NA 63

  Fly   684 HVMDE--------LKYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEISGDPPMDADKYALYVLD 740
            |:.::        :..|||      |...|.:|:.:....|      :|.......:.:.||...
 Frog    64 HLTNQNNWLRTNYISRGLA------SYAYVEITFTMLECSF------LSRAGRSCKETFNLYYYQ 116

  Fly   741 -NRDLDELWGPNQTVFIRKGGVFFHF-----NPKLCVSTINQLLPMLASKPKFFEKSDVGADSNG 799
             |.||     .|.           ||     ||.:.|.|                   |.||..|
 Frog   117 ANHDL-----AND-----------HFPPWMENPWVRVDT-------------------VAADFLG 146

  Fly   800 ---NRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDPRAFIGF----VFYH 857
               .|||.|:..|||....:|                |.......:.|:|..|.:..    |||.
 Frog   147 RPNRRGSPGSTRLNVKTLRIG----------------PLSGDGFYLAFQDQGACMALLAVRVFYR 195

  Fly   858 MIDPYGNSTKSSDDPCDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAISSELTNAESDVKNF 922
            :              |.             .|:::|..:
 Frog   196 V--------------CP-------------AVVASLASF-------------------------- 207

  Fly   923 RTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVK 987
                  |..|:|.:..:...|.:...    :.|.|            .:||.     ||.|
 Frog   208 ------PKTVSEGLVVSAEGSCVEGA----EGPLG------------RKPTM-----YCRE---- 241

  Fly   988 AMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKS- 1051
                       ..:.:.|..|:|.||.|      :|..|.:.:.     .|.....|.|.:.:.
 Frog   242 -----------DGEWAKPAVGECACVAG------REEKDGRTKC-----TACAPGYFKPTVGEKP 284

  Fly  1052 -----KNGSSDK--------SDGAEGAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGS-VLL 1102
                 .||.|..        ..|...||:|.   |....:.|....|.:...     |.|| |.|
 Frog   285 CQPCPANGLSTAPGATVCGCKPGYYRAAMDP---PTAACSTPPSAPRSIVAR-----VNGSGVDL 341

  Fly  1103 RHVRSITDDTDAFFEKDDENTYKDEEDLSSNKQFYEVFAKE-------LPPNQTHFVFEKLRHFT 1160
            ..    ::..||....|               .:|||...|       :|.::.:|.....|...
 Frog   342 EW----SEPLDAGGRGD---------------LYYEVQCSECAGGGPCIPCSRLNFTPRPQRLVD 387

  Fly  1161 RYAIFVVACREEIPSE----KLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTE 1221
            | .:.|...|..:...    .|...|.:.:..:..:.|..||.|    |:.:.:. .::....:|
 Frog   388 R-RLRVAGLRPRVTYNFRVLALNGVSERSTSGALGEEVNVTTDR----DVPLPVS-GIQQMAASE 446

  Fly  1222 SPVRVRWTPPV---DPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGYLIKLNEG-LYSFR 1282
            :.:.:||..|:   ...|.|:.|||.|..:  ||  ||..|...........|.:|..| :|..:
 Frog   447 TTLTLRWATPLHSAPTKGNILDYEVKYYAK--DQ--EKPLIKFMKTTSNEALLAELLSGTVYVVQ 507

  Fly  1283 VRANSIAGYGDFTEVEHIKVEPPPSYAKVFFWLL----GIG-LAFLIVSLFGYVC---------- 1332
            |||.:.||||.|:....::....|..|:....|:    |:| |..|.|.:...||
 Frog   508 VRARTEAGYGAFSGDTLVQTLEGPEKAQPQVALIAGTAGVGTLLVLAVIVTAVVCIRKHGSSKEP 572

  Fly  1333 --------YL--HKRKVPSNDLHMNTEVNPFYASMQYIPDDWEVLRE-------NIIQLAP-LGQ 1379
                    ||  |..||         .::||     ...|..|.:||       :.:::.. :|.
 Frog   573 EYCDKPGQYLIGHNSKV---------YIDPF-----TYEDPNEAVREFAKEIDVSCVKIEEVIGA 623

  Fly  1380 GSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRG 1444
            |.||.|..|.||  .|...:...||||:....|:|:|..||||||:|.:|:..:::.|.||.:..
 Frog   624 GEFGEVCRGRLK--VPGKKENYVAIKTLKGGYTERQRREFLSEASIMGQFNHPNIIHLEGVITNN 686

  Fly  1445 QPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAY 1509
            .|.:::.|.|:.|.|.|:||      :::...|.:..:|               |...||.||.|
 Frog   687 CPVMIITEYMENGALDSFLR------QNDGQFTPIQLVG---------------MLRGIASGMRY 730

  Fly  1510 LAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYE--TD-YYRKGTKGLLPVRWMPPESLRDG 1571
            ||...:|||||||||.:|..:|..|:.|||::|.:.|  || .|.....|.:|:||..||::...
 Frog   731 LAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLQEGSTDPTYTSCLGGKIPIRWTAPEAIAFR 795

  Fly  1572 VYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHR 1636
            .::|||||:.:|:|:||:.:...:||..:||:.|:..:.....:..|.:||..||:||..||...
 Frog   796 KFTSASDVWGYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPAPPDCPTALHQLMLDCWQRD 860

  Fly  1637 SSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQ--LD-------AFAAVPL 1692
            .:.||.|.||::.|:           ....:.|.|:...:|:...:|  ||       :|::|
 Frog   861 RALRPRFADIVSSLD-----------KLIRNPASLKITTREQLGTSQPLLDQRTPHYSSFSSV-- 912

  Fly  1693 DQDLQDREQQEDATTPLRMGDYQQ 1716
            .:.||          .::||.|::
 Frog   913 SEWLQ----------AIKMGRYEE 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614	6/25 (24%)
		Recep_L_domain	663..781	CDD:460032	23/131 (18%)
		FN3	791..>964	CDD:442628	28/179 (16%)
		FN3	1224..1302	CDD:238020	26/81 (32%)
		PTKc_InsR_like	1364..1652	CDD:173625	103/298 (35%)
ephb4	XP_031755496.1	EphR_LBD_B4	17..196	CDD:198442	54/259 (21%)
		FN3	<321..>548	CDD:442628	58/260 (22%)
		EphA2_TM	541..612	CDD:464211	18/84 (21%)
		PTKc_EphR_B	610..878	CDD:173638	100/301 (33%)
		SAM_superfamily	907..>945	CDD:472832	7/32 (22%)