Protein Alignment InR and insr

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_002934425.2
• Gene: insr / 100492718
• XenbaseID: XB-GENE-920733
• Length: 1360
• Species: Xenopus tropicalis
• Alignment Length: 1472
• Identity: 553/1472 - (37%)
• Similarity: 760/1472 - (51%)
• Gaps: 233/1472 - (15%)

  Fly   337 KPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASPLN---RSFPKLTEVTDYIIIYRVTGLH 398
            |.|.||||||.:|.|:.||:||||||.|.|.|:..:.|.|   ..|||||.:|||::::||.||.
 Frog    43 KICPSMDIRNNISQFSMLEDCTVIEGHLQILLMFTSKPENFRGLRFPKLTMITDYLLLFRVYGLE 107

  Fly   399 SLSKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLE 463
            ||..:||||:||||..||..||||::....|.::||:.|.:||||.||||||::|||..||||..
 Frog   108 SLKDLFPNLTVIRGTHLFFNYALVIFEMVHLKEIGLYNLMNITRGSVRIEKNNELCYLSTIDWSI 172

  Fly   464 ILAENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASC-QLHNNRRL---CWNS 524
            ||...|...:.|..:.|| ||. ..|||             .|:..:.| |:..|...   ||..
 Frog   173 ILDSVEDNYIELNRDNKE-ECG-DVCPG-------------AGKGKSKCKQIVVNGAFIERCWTQ 222

  Fly   525 KLCQTKCPEKCR-NNCIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQFD 588
            ..|||.||.:|: :.|:.:..||..:|||.| ...|....|.:||:..:..:|:.:||:|.|:|.
 Frog   223 DHCQTVCPSECKGSGCLPDGQCCHSECLGSC-RKPNDPTECTACRHYQYQGVCISACPEGSYRFQ 286

  Fly   589 S-RCVTANECITLTKFETNSVYSGIPY---NGQCITHCPTGYQKSENKRMCEPCPGGKCDKEC-- 647
            . ||:..|.|..:.....|...|..||   .|:|:..||:||..:...|.|.|| .|.|.|.|
 Frog   287 GWRCIDFNTCQEMHNRCPNKENSCPPYVIHKGECMPDCPSGYIANSTTRTCTPC-AGPCPKVCTI 350

  Fly   648 --SSGLIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYG 710
              |...|||:..|:|..|||::.|:  |.|:|:  .|.::..||:..|..:.:|...|.:..:|.
 Frog   351 YQSVKTIDSVTSAQELRGCTVVNGS--LIINIR--GGNNIATELEANLGLIEEISGYLKIRRSYA 411

  Fly   711 LKSLKFFQSLTEISGDPPMDADKYALYVLDNRDLDELWG---PNQTVFIRKGGVFFHFNPKLCVS 772
            |.||.||:.|..|.|: .::|..|:.|.|||..|.:||.   .|.|:.  .|.:|||.||:||::
 Frog   412 LVSLSFFRKLRLIRGE-VLEAGNYSFYALDNPSLRQLWDWHKHNLTII--HGKLFFHHNPRLCLA 473

  Fly   773 TINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKP 837
            .|:|:..:..:|.: .:|:|:...:||::.||...:||........:..:|.       .:|..|
 Frog   474 EIHQMEEVTGTKGR-QDKNDISTKTNGDQASCEDNLLNFNFIRTSHDMVLLK-------WDPYWP 530

  Fly   838 SNATIVFKDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRWKV---SSPEKSG-------VMVL 890
                   .|.|..:||:.::...||.|.|: ...|.| .:.|.|   .:||:|.       ..:|
 Frog   531 -------PDYRDLLGFMVHYKEAPYQNVTEFDGQDACGSNSWTVVDMDAPERSADGKTLSPGCLL 588

  Fly   891 SNLIPYTNYSYYVRTMAISSE---LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYL 952
            .||.|:|.|:.:|:|:...|:   ...|:|.:...|||...||...:..:.:.|.|:|.:.|...
 Frog   589 RNLKPWTQYAVFVKTLVSGSDEGRTYGAKSKIIYIRTNETIPSVPLDPFSVSNSTSQIILKWKPP 653

  Fly   953 DKPYGVLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPAT--TPTKKISD---------PL 1006
            .:|.|.:|.|.:..:.....:.....|||.:.|      .||:.  ||...|.:         |.
 Frog   654 SEPNGNVTHYLVYWQEQPEDSELYELDYCNKGL------KLPSRTWTPPSDIEENGNINQTDQPS 712

  Fly  1007 AGDCKCVEGSKKTSSQ---EYDD---RKVQAGMEFENALQNFIFVPN-IRKSKNGSSDKSDGAEG 1064
            :..|.|    .||..|   |.|:   ||.     |||.|.|.:|:|. :||.:
 Frog   713 SKCCPC----PKTDFQIQKEQDESAFRKT-----FENYLHNEVFIPRPVRKRR------------ 756

  Fly  1065 AALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEED 1129
               :...:.||...:|       ...|.|.:...:       ...|:|              |..
 Frog   757 ---ELFGVANGTLPDP-------VTAPSLFNASST-------RAPDET--------------EPK 790

  Fly  1130 LSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTV 1194
            :.|.|    |:.||      ..:...|:|||.|.|.:.||..|:...           ||....|
 Frog   791 IYSQK----VWFKE------SLMVTGLKHFTGYRIEIHACNHELSMG-----------CSVAAYV 834

  Fly  1195 FQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEK-KC 1258
            ...|..:..||.|:. .:..|:..  .:.:.::|..|.||||.||.|||.|  .:....||. .|
 Frog   835 SARTMPEATADNVVG-PITYEYIE--PNIIHLKWQEPKDPNGLIVLYEVHY--SRVGGTEEVISC 894

  Fly  1259 IPAADFNQTAGYLIK-LNEGLYSFRVRANSIAGYGDFTEVEHIKV--EPPPSYAKVFFWLLGIGL 1320
            :....::...|..:: |..|.||.::||.|:||.|.:||..:.:|  .|..|..|:   :.|..:
 Frog   895 VSQKQYSTDKGAKLRVLTPGNYSVKIRATSLAGNGSWTEPAYFQVPDHPHSSIVKI---VTGPVI 956

  Fly  1321 AFLIVSLFGYVCYLHKRK---VPSNDLHMNTEVNPFY--ASMQYIPDDWEVLRENIIQLAPLGQG 1380
            |.:::......|.:.|:|   .|...|:.::  ||.|  ||..||||:|||.|:.|..|..||||
 Frog   957 AVILLLFVLVYCVIQKKKDAEGPVGPLYASS--NPEYLSASEVYIPDEWEVPRDKISLLRELGQG 1019

  Fly  1381 SFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSRGQ 1445
            |||||||||.|.......:...|:|||||:|:.|||..||:||||||.|..:||||||||.|:||
 Frog  1020 SFGMVYEGIAKDIIKGEPEVRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQ 1084

  Fly  1446 PALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQP-PTYGRIYQMAIEIADGMAY 1509
            |.||:||||..||||||||:.||:..        |..|     :| ||...:.|||.||:|||||
 Frog  1085 PTLVIMELMTHGDLKSYLRSLRPDAE--------NNPG-----RPAPTLKEMIQMAAEISDGMAY 1136

  Fly  1510 LAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYS 1574
            |.|||||||||||||||||:|.||||||||||||||||||||||.|||||||||.||||:|||::
 Frog  1137 LNAKKFVHRDLAARNCMVAEDYTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFT 1201

  Fly  1575 SASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSA 1639
            :.|||:||||||||:.:||.||||||||||||::|:|||.:::|||||..||.|||.||.:....
 Frog  1202 TFSDVWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGSLDQPENCPPRLHSLMQMCWQYNPKM 1266

  Fly  1640 RPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQ-DREQQE 1703
            ||:||:||..|:... :..|:|||||:|:        |.|.          |...||: |.|..|
 Frog  1267 RPTFLEIIDMLKDDL-HLSFQEVSFYYSD--------ENKP----------PETDDLEIDFENME 1312

  Fly  1704 DATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLPFSLPSG 1745
              :|||   |....|..||.....|     ...|:|::..:|
 Frog  1313 --STPL---DPSSCSLRDQSNRGNI-----YEEHIPYTHMNG 1344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	60/111 (54%)
		Furin-like	510..645	CDD:395614	48/143 (34%)
		Recep_L_domain	663..781	CDD:460032	43/120 (36%)
		FN3	791..>964	CDD:442628	49/187 (26%)
		FN3	1224..1302	CDD:238020	28/79 (35%)
		PTKc_InsR_like	1364..1652	CDD:173625	187/288 (65%)
insr	XP_002934425.2	Recep_L_domain	62..174	CDD:460032	60/111 (54%)
		Furin-like	189..346	CDD:395614	56/173 (32%)
		Recep_L_domain	368..483	CDD:460032	43/121 (36%)
		FN3	<510..>666	CDD:442628	43/169 (25%)
		FN3	630..>673	CDD:238020	10/42 (24%)
		FN3	851..939	CDD:238020	29/91 (32%)
		PTKc_InsR	1003..1290	CDD:133192	190/300 (63%)