DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment InR and insrr

DIOPT Version :9

Sequence 1:NP_001138093.1 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster
Sequence 2:XP_004917407.2 Gene:insrr / 100490498 XenbaseID:XB-GENE-483108 Length:1360 Species:Xenopus tropicalis


Alignment Length:1454 Identity:549/1454 - (37%)
Similarity:770/1454 - (52%) Gaps:232/1454 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   339 CKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASP---LNRSFPKLTEVTDYIIIYRVTGLHSL 400
            |.||||||.||.|.:|||||||:|.|.|.|:....|   ....|.:||.:|:|::::||.||.||
 Frog    33 CGSMDIRNDVSQFRKLENCTVIQGNLQILLMFSTKPEDFRGLRFERLTMITEYLLLFRVYGLESL 97

  Fly   401 SKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEIL 465
            ..:|||||:|||..||..|:||::....|.|:|||.|.:|..|.||||:|.:||:..|||| .:|
 Frog    98 RDLFPNLSIIRGTDLFFHYSLVIFEMPHLRDIGLHSLTNILNGAVRIERNQELCHISTIDW-SLL 161

  Fly   466 AEN-ETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQT 529
            :|: |...:|  .|...:|| ...|||.....|....|.|.|.:.:.         ||.|..||.
 Frog   162 SESVENNYIV--GNKPVEEC-ADVCPGIRDSGESCIKTPINGNMESR---------CWTSTSCQK 214

  Fly   530 KCPEKCRNN--CIDEHTCCSQDCLGGCVIDKNGN-ESCISCRNVSFNNICMDSCPKGYYQFDS-R 590
            .||  |:.:  |.:...||..:|||||  :|.|: .:|::|||...::.|:.|||.|.::::. |
 Frog   215 VCP--CKEDIACSNTGECCHPECLGGC--NKAGDPRACVACRNFYIDDQCLPSCPPGTFEYEGWR 275

  Fly   591 CVTANECITLTKFETNSVYSG-IPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSG--LI 652
            |:....|..|.|...||..:. :.:..:|::.||:||.::::...|..|. |.|.|.|.:|  :|
 Frog   276 CIEEAYCGNLLKESENSESTKFVIFENRCLSECPSGYTRNDSSIFCHKCE-GLCPKTCKAGNKVI 339

  Fly   653 DSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLKFF 717
            ||||.|:|..|||.|.|.  |.::|:|  |.::..||:..|..:..|...|.:..::.|.||.||
 Frog   340 DSLEAAKELTGCTNIEGN--LILNIRR--GHNLASELQQSLGLIETITGFLKIKHSFALVSLSFF 400

  Fly   718 QSLTEISGDPPMDADKYALYVLDNRDLDELWGPNQTVFIRKGGVFFHFNPKLCVSTINQLLPMLA 782
            ::|..|.||..:|.: |.||:|||::|.:||.| :::.|..|.::|.||||||:|.|..:..:..
 Frog   401 KNLKLIRGDTMVDGN-YTLYILDNQNLLQLWTP-ESLSIPVGKLYFAFNPKLCLSEIYHMEEITG 463

  Fly   783 SKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVFKDP 847
            ::.: ..|:|:...:||::.||....|........|:    .:..|.|..:|  |.:        
 Frog   464 TRGR-QNKADINPRTNGDQASCNIRPLRFVSNWTEAD----RINLKWERYQP--PGH-------- 513

  Fly   848 RAFIGFVFYHMIDPYGNSTK-SSDDPCD-DRWKV------SSPEKSGVMVLSNLIPYTNYSYYVR 904
             ..:.||.::...|:.|.|: ...|.|. :.|.|      .:.|:...:.|:||.|:..|:.|||
 Frog   514 -DLLSFVVHYKESPFQNITEYLGQDACGANSWNVVDVELPLNNEQEPSVTLTNLKPWVQYAIYVR 577

  Fly   905 TMAISSELT----NAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYGVLTRYFI- 964
            .:.:::|..    .|:|||...||.|..|:...:|:..:.|.|.:.|.|....:..|.||.|.: 
 Frog   578 AITLTAEENGRKFGAQSDVVYIRTRPAAPTVPQDVMIMSNSSSHLIVRWKPPTQRNGNLTYYLVL 642

  Fly   965 -KAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGD-----------CKCVEGSK 1017
             :..:.::....||  |||:.|      .||.::...:..:...|:           |.|    :
 Frog   643 WQQMVEDKELYLNN--YCTKGL------KLPTSSADTRFDNDDNGNQDPNQDTEDKCCPC----Q 695

  Fly  1018 KTSS--QEYDDRKVQAGMEFENALQNFIFVPN-------IRKSKNGSSDKSDGAEGAALDSNAIP 1073
            |...  .|.|:...|  .:|||.|:|.||:|.       |.|                 |:...|
 Frog   696 KDGGLHPEMDEGSFQ--KKFENFLRNTIFIPKPPWKVTLINK-----------------DNQRAP 741

  Fly  1074 NGGATNPSRRRRDV-ALEPEL----DDVEGSVLLRHVRSITD-DTDAFFEKDDENTYKDEEDLSS 1132
                    :||||| .:.||:    ...||:|  .|..:.|. |:..:       :|||      
 Frog   742 --------KRRRDVPGMNPEVLGNASLPEGTV--SHTINHTGVDSKPY-------SYKD------ 783

  Fly  1133 NKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACRE--EIPSEKLRDTSFKKSLCSDYDTVF 1195
                 :||...:       |...|||||.|.|.:.||..  ||..            ||....||
 Frog   784 -----KVFLNRM-------VISNLRHFTEYRIDIHACNHAAEIVG------------CSAATFVF 824

  Fly  1196 QTTKRKKFAD-IVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCI 1259
            ..|.:...|| ||.::..::    ..::.:.::|..|.:|||.|:.||:.||....:......|:
 Frog   825 ARTMQDPLADNIVGNITWEV----TAKNAILMKWEEPKNPNGLILKYEIKYKRDHEEGPPTVVCV 885

  Fly  1260 PAADFNQTAG-YLIKLNEGLYSFRVRANSIAGYGDFTEVEHIKVEPP---PS-----YAKVFFWL 1315
            ....|.:..| :|..|..|.||.|:||.|:||.|.:||.....:..|   ||     ..||...:
 Frog   886 SRQQFQRYKGVHLTLLQPGNYSARIRATSLAGNGSWTEPMVFFILGPAEEPSENLYLLLKVLPII 950

  Fly  1316 LGIGLAFLIVSLFGYVCYLHKRKVPSNDLHMNTEVNP--FYASMQYIPDDWEVLRENIIQLAPLG 1378
            |.:.:|||.|.:|.|....:....|:..|:  ..|||  |.||..|:||:||..||||..:..||
 Frog   951 LLVVIAFLAVFIFFYNKKGNNNGYPNGTLY--ASVNPEYFSASDMYVPDEWEFPRENITIIKELG 1013

  Fly  1379 QGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVCSR 1443
            ||||||||||:.|....|......|:|||||.||.|||..||:||||||.|..:||||||||.|:
 Frog  1014 QGSFGMVYEGVAKDIVKNEPVTRVALKTVNELATTRERIEFLNEASVMKAFLCHHVVRLLGVVSQ 1078

  Fly  1444 GQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMA 1508
            ||||||:||||.:||||||||:.||:|.:       |..|     ..|:..|:.|||.|||||||
 Frog  1079 GQPALVIMELMTRGDLKSYLRSLRPDEEN-------NHPG-----NQPSLKRMIQMAGEIADGMA 1131

  Fly  1509 YLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPESLRDGVY 1573
            ||.||||||||||||||||::||||||||||||||||||||||||.|.|||||||.||||:||::
 Frog  1132 YLTAKKFVHRDLAARNCMVSEDLTVKIGDFGMTRDIYETDYYRKGGKSLLPVRWMSPESLKDGIF 1196

  Fly  1574 SSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSS 1638
            ::.|||:||||||||:||||.|||||::|||||.:|||.|::|:||||||.||:||:.||.....
 Frog  1197 TTYSDVWSFGVVLWEIATLAEQPYQGMANEQVLHFVIDNGILEKPENCPDRLHELMRWCWQKNPK 1261

  Fly  1639 ARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKERNQLDAFAAVPLDQDLQDREQQE 1703
            .||||:.|:..::.:.|.| |::|||.:|:        |||....::. :...:||.|       
 Frog  1262 HRPSFIQILESIKDELPTS-FQQVSFCNSQ--------ERKRSGSMET-SDTEVDQSL------- 1309

  Fly  1704 DATTPLRMGDYQQNSSLDQPPESP 1727
                         |:.||||| ||
 Frog  1310 -------------NNLLDQPP-SP 1319

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
InRNP_001138093.1 Recep_L_domain 356..465 CDD:279382 53/111 (48%)
Furin-like 512..645 CDD:279142 43/137 (31%)
FU 545..592 CDD:238021 19/48 (40%)
Recep_L_domain 663..781 CDD:279382 45/117 (38%)
FN3 1224..1302 CDD:238020 27/78 (35%)
PTKc_InsR_like 1364..1652 CDD:173625 187/287 (65%)
Pkinase_Tyr 1371..1650 CDD:285015 182/278 (65%)
insrrXP_004917407.2 Recep_L_domain 50..161 CDD:395817 53/111 (48%)
Furin-like 177..330 CDD:395614 52/167 (31%)
Recep_L_domain 350..456 CDD:395817 44/111 (40%)
FN3 492..601 CDD:238020 28/123 (23%)
FN3 606..>650 CDD:238020 10/43 (23%)
FN3 837..927 CDD:238020 28/93 (30%)
PTKc_InsR_like 999..1275 CDD:173625 187/287 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 364 1.000 Domainoid score I934
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 804 1.000 Inparanoid score I487
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D120934at33208
OrthoFinder 1 1.000 - - FOG0001171
OrthoInspector 1 1.000 - - otm49127
Panther 1 1.100 - - O PTHR24416
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X893
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

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