Protein Alignment InR and ntrk1

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_002939035.2
• Gene: ntrk1 / 100489637
• XenbaseID: XB-GENE-923001
• Length: 808
• Species: Xenopus tropicalis
• Alignment Length: 643
• Identity: 190/643 - (29%)
• Similarity: 271/643 - (42%)
• Gaps: 175/643 - (27%)

  Fly  1108 ITDDTDAFFEKDDENTYKDEEDL-------SSNKQFYEVFAKEL-PPNQTHFVFEKLRHFTRYAI 1164
            |..:.|::.|....|..:.|..|       ..||:.....|:.: .|::.|.....|     :..
 Frog   237 IVPEMDSYTEIGQSNGSETEIFLPLFNISPGFNKRNVTCRAENMVGPSEEHVQINVL-----FPA 296

  Fly  1165 FVVACREEIPSEKLRDTSFKKSLCSDYDTVFQTTKRKKFADIVMDLKVDLEHANNTESPVRVRWT 1229
            .|||..|.||         :...|..| ||....|.:                        :||
 Frog   297 MVVALEEAIP---------QHHFCFPY-TVDGNPKPE------------------------IRW- 326

  Fly  1230 PPVDPNGEIVTYEVAYKLQKPD-----QVEEKKCIPAADFNQTA--G--YLIK---LNEGLYSFR 1282
               ..||        :.|:..|     .|||.:       |.||  |  ||.|   :|.|.|:..
 Frog   327 ---QFNG--------HNLEMNDYIYLKTVEESE-------NSTAIHGCLYLNKPTHVNNGNYTIL 373

  Fly  1283 VRANSIAGYGD------------FTEVEHIKVEPPP------SYA--------KVFFWLLGIGLA 1321
            | .|.:....:            |...|.|.|...|      :|.        ..|...:.:|||
 Frog   374 V-WNMLGSASETVYSKFMDNPFSFNPEEPIPVSLSPEGGGNSTYTTTVETVEENTFGVSVAVGLA 437

  Fly  1322 -----FLIVSLFGY-VCYLHKR--------KVPSNDL-----HMNTEVNP--------------F 1353
                 ||::.|... .|..|.:        ....:||     .||...:|              |
 Frog   438 VFACLFLLLILIALNKCGRHSKFGINRAAVLAQEDDLAMSLHFMNFGTSPLTSAEGKLDGMKPNF 502

  Fly  1354 YASMQYIPDD--WEVLRENIIQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRER 1416
            ..:.||..|.  ..:.|.:|:....||:|:||.|:.....:..|.......|:|.:.| ||:..|
 Frog   503 IENPQYFCDACVQHIKRRDIVLKWELGEGAFGKVFLAEFYNLTPENEKTLVAVKALKE-ATENAR 566

  Fly  1417 TNFLSEASVMKEFDTYHVVRLLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNR 1481
            .:|..||.::......|:|:..|||:.|:|.::|.|.||.|||..:||:|.|:.          :
 Frog   567 QDFQREAELLTVLQHEHIVKFYGVCTDGEPLIMVFEYMKHGDLNRFLRSHGPDA----------K 621

  Fly  1482 IGVTGNVQPPTYGRI-----YQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMT 1541
            |...||.||  ||::     .|:|.:||.||.|||:..|||||||.|||:|.::|.||||||||:
 Frog   622 ILDNGNGQP--YGQLNLTQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGNNLVVKIGDFGMS 684

  Fly  1542 RDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVL 1606
            ||||.|||||.|.:.:||:|||||||:....:::.||::||||||||:.|...||:..|||.:.:
 Frog   685 RDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLSNTEAI 749

  Fly  1607 RYVIDGGVMERPENCPDFLHKLMQRCWHHRSSAR-----------------PSFLDII 1647
            ..:..|..:|||..||..::.:||.||......|                 |.:|||:
 Frog   750 ECITQGRQLERPRTCPTEVYNIMQGCWQREPQQRLNIKEIHNKLQALVKAPPVYLDIL 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	24/101 (24%)
		PTKc_InsR_like	1364..1652	CDD:173625	122/306 (40%)
ntrk1	XP_002939035.2	LRR_8	97..156	CDD:404697
		leucine-rich repeat	99..122	CDD:275378
		leucine-rich repeat	123..145	CDD:275378
		LRRCT_2	157..201	CDD:465313
		Ig	211..292	CDD:472250	11/54 (20%)
		Ig strand B	220..224	CDD:409353
		Ig strand C	233..237	CDD:409353	190/643 (30%)
		Ig strand E	257..261	CDD:409353	1/3 (33%)
		Ig strand F	272..277	CDD:409353	0/4 (0%)
		Ig strand G	285..288	CDD:409353	0/2 (0%)
		Ig	295..390	CDD:472250	32/148 (22%)
		Ig strand B	310..314	CDD:409353	1/3 (33%)
		Ig strand C	323..327	CDD:409353	2/31 (6%)
		Ig strand E	355..359	CDD:409353	1/3 (33%)
		Ig strand F	369..374	CDD:409353	1/4 (25%)
		Ig strand G	382..385	CDD:409353	0/2 (0%)
		PTKc_TrkA	516..795	CDD:270674	118/291 (41%)