Protein Alignment slou and Nanog

DIOPT Version :10

• Sequence 1: NP_001262808.1
• Gene: slou / 42547
• FlyBaseID: FBgn0002941
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_082292.1
• Gene: Nanog / 71950
• MGIID: 1919200
• Length: 305
• Species: Mus musculus
• Alignment Length: 243
• Identity: 59/243 - (24%)
• Similarity: 90/243 - (37%)
• Gaps: 67/243 - (27%)

  Fly   403 GSHSTPSVCPVDLTRSVNSSAAANPSSASTSASSDRDAATKRLAFSVENILDPNKFTGNKLPSGP 467
            |.||.||           |..|:|..:||:.                     |..|
Mouse     7 GPHSLPS-----------SEEASNSGNASSM---------------------PAVF--------- 30

  Fly   468 FGHPRQWSYERDEEMQERLDDDQSEDMSAQDLNDMDQDDMCDDGSDIDDPSSETDSKKGGSRNGD 532
              ||..:|..:....:....:..|...|::||......|           ||.:..:|..|...|
Mouse    31 --HPENYSCLQGSATEMLCTEAASPRPSSEDLPLQGSPD-----------SSTSPKQKLSSPEAD 82

  Fly   533 -GKSGGGGGGGSKPRRARTAFTYEQLVSLENKFKTTRYLSVCERLNLALSLSLTETQVKIWFQNR 596
             |.........::.::.||.|:..||.:|:::|:..:|||:.:...|:..|:|:..|||.||||:
Mouse    83 KGPEEEENKVLARKQKMRTVFSQAQLCALKDRFQKQKYLSLQQMQELSSILNLSYKQVKTWFQNQ 147

  Fly   597 RTK--------WKKQNPGM-DVNSPTIPPPGGGSFGPGAY---ASGLL 632
            |.|        |.|.:.|: ...|..:..|......|..|   |||.|
Mouse   148 RMKCKRWQKNQWLKTSNGLIQKGSAPVEYPSIHCSYPQGYLVNASGSL 195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slou	NP_001262808.1	Homeodomain	546..602	CDD:459649	23/63 (37%)
Nanog	NP_082292.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		11/54 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	46..95		11/59 (19%)
		Sufficient for interaction with SALL4. /evidence=ECO:0000269|PubMed:16840789	96..155		22/58 (38%)
		Homeodomain	98..153	CDD:459649	22/54 (41%)
		Required for DNA-binding. /evidence=ECO:0000250|UniProtKB:Q9H9S0	123..152		12/28 (43%)
		PTZ00395	<190..>250	CDD:185594	4/6 (67%)
		10 X repeats starting with a Trp in each unit	198..247
		Sufficient for transactivation activity	198..247
		Sufficient for strong transactivation activity	248..305