DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slou and Npm1

DIOPT Version :9

Sequence 1:	NP_001262808.1	Gene:	slou / 42547	FlyBaseID:	FBgn0002941	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_032748.1	Gene:	Npm1 / 18148	MGIID:	106184	Length:	292	Species:	Mus musculus

Alignment Length:	272	Identity:	60/272 - (22%)
Similarity:	85/272 - (31%)	Gaps:	86/272 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   353 DYGFRI-------QLGGLAAAAAAAAATSRQIAAATYARSDTSEELNVDGN-------------- 396
            ||.|::       ||.....:..|.|.....|..|        |.:|.:|:
Mouse    28 DYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEA--------EAMNYEGSPIKVTLATLKMSVQ 84

  Fly   397 DEDSNDGSHSTPSV-----C---PVDLTRSVNSSAAANPSSASTSASSDRDAATKRLAFSVENIL 453
            ...|..|...||.|     |   ||.::   .....|....|.:....:.|  .|.|..|.:...
Mouse    85 PTVSLGGFEITPPVVLRLKCGSGPVHIS---GQHLVAVEEDAESEDEDEED--VKLLGMSGKRSA 144

  Fly   454 DPNKFTGNKLPSGPFGHPRQWSYERDEEMQERLDDDQSEDMSAQDLNDMDQDDMCDDGSDIDDPS 518
            ...   |||:|        |...:.||:     |:|..||         |:||..||..|.|:..
Mouse   145 PGG---GNKVP--------QKKVKLDED-----DEDDDED---------DEDDEDDDDDDFDEEE 184

  Fly   519 SE-----------TDSKKGGSRNGDGKSGGGGGGGSKPRRARTAFTYEQLVSLENKFKTTRYLSV 572
            :|           |.:|.....|.:||.       .||...|:. ..|.....|...||.:..|.
Mouse   185 TEEKVPVKKSVRDTPAKNAQKSNQNGKD-------LKPSTPRSK-GQESFKKQEKTPKTPKGPSS 241

  Fly   573 CERLNLALSLSL 584
            .|.:...:..|:
Mouse   242 VEDIKAKMQASI 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slou	NP_001262808.1	Homeobox	549..601	CDD:278475	8/36 (22%)
Npm1	NP_032748.1	Required for interaction with SENP3. /evidence=ECO:0000250	1..185		44/194 (23%)
		Necessary for interaction with APEX1. /evidence=ECO:0000250	1..117		20/99 (20%)
		Nucleoplasmin	18..116	CDD:308605	20/98 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..248		34/142 (24%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		2/12 (17%)
		Nuclear localization signal. /evidence=ECO:0000255	190..196		0/5 (0%)
		Required for nucleolar localization. /evidence=ECO:0000250	241..292		2/13 (15%)
		NPM1-C	243..291	CDD:318505	2/11 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900