Protein Alignment slou and Gbx2

DIOPT Version :10

• Sequence 1: NP_001262808.1
• Gene: slou / 42547
• FlyBaseID: FBgn0002941
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_034392.1
• Gene: Gbx2 / 14472
• MGIID: 95668
• Length: 348
• Species: Mus musculus
• Alignment Length: 1684
• Identity: 327/1684 - (19%)
• Similarity: 513/1684 - (30%)
• Gaps: 543/1684 - (32%)

  Fly   272 APNQSAAKGGGSTVPDGYGYYYSNQPPPLTCSPTETQSAISAALGNGGGGGGGGPSTGLLLSDED 336
            ||.|:....     |....:.:.:..||:....:|..:|....:.|              |..:.
Mouse   915 APQQATVAD-----PSYQSHSFPHSAPPVLAHASEPNTAFEFHMHN--------------LQADP 960

  Fly   337 DTRDERLKREAAGAGPTPRWMERNYCHLSVSHYPSTGHKSKGGGPGVGGGSTGSGGGGGSMMQPP 401
            .....||.|...|:      |:.|.             :..||.||:           .|.:||.
Mouse   961 AMLASRLYRARRGS------MDLNL-------------EEAGGNPGL-----------CSRLQPV 995

  Fly   402 KRASVVGSGSTYKPVSCYNMVLQSPLE-------DESDMEDKLKYFN-YQHEM-QTYNGTRKDKL 457
            .. .:....|...|:...:::|..|.|       |.....|..::.: ..|:: ||...:....:
Mouse   996 TE-ELYSYVSPELPLPPGSLLLHGPKELSPEPSSDSMTSSDAGEFHSPPPHQLYQTQECSAAQSI 1059

  Fly   458 GLGGY-----GALGGDGGAAGEGEIVVL-----SSNAKEHGNTLSVAQPKQQDLPDEGPTARKGL 512
            ....|     |:...||....:...:.:     |:.:..|.|    |..:|..||.:.......|
Mouse  1060 PQAAYYKTDGGSNVSDGHPPSQPTFLFVPHSESSTISSSHIN----AWARQPSLPPDLTFHEPAL 1120

  Fly   513 LHLGQKLEHGPHVGLSVASPSVEQCEPAVDFADKLLGHY---------PAKRDEG---------- 558
            .|.|..|...| :..|.:..|:..|......|.:..|.|         |.::...
Mouse  1121 SHQGATLVQVP-IPQSTSGMSLASCSTPAASASQQYGVYYVQALPTQAPVQQPASLGPTSQPCAS 1184

  Fly   559 --EAELAENKSQSTGSNIIEYDGSPRRFGLNLCDESDCY----------------LASSVKINLT 605
              :.:..:..|.:...:|.:...:|.:    ||..:.|.                |.|......|
Mouse  1185 LPQQQTPQQPSSTVAQSISQTQITPTQ----LCSPALCVPTIAVTPFQQQPVPEALTSLKTAPAT 1245

  Fly   606 SPSLLSLPRPGFPQRVVPATVGTAGSGSSMAGTVAQTSSTNASCSPS-LLDQVNSTLSKTLLLD- 668
            |||:|....|......|| |:..|        ||  .|.|...|.|: .|.|.:.:.|:||..:
Mouse  1246 SPSMLPPHVPLLVTTPVP-TIHVA--------TV--PSPTEHPCLPADALAQTSHSASQTLTTEL 1299

  Fly   669 SKRSANDTECTSSYGAGELSK----VSGTRKE-QQQQQHQQH------HDHHIYDMLPGKLSPSE 722
            |:......|.:.|..|..||.    |:|.|.| :..::||:.      .:.....:....|:.|.
Mouse  1300 SQLQTPAVESSHSDVASGLSDGNEGVTGGRHEGRPAKRHQRRSVRSRSRNEKTSKVKLSVLNISS 1364

  Fly   723 MGGKTS---LE---------KLQLSAQTPENELQHIGGTSGFPPIANSSTFDYLYEFSETRKVLE 775
            ||.:.:   ||         |..|....|| |:..|...|.|                    :||
Mouse  1365 MGDRVAECQLETHNRKMVTFKFDLDGDNPE-EIAQIMVQSEF--------------------ILE 1408

  Fly   776 EFFKCPSTEDVEKFSD-YNDSAEEEDEEDGEEE------DGESLDVHYDYPVELER--SKTIETT 831
                    .:.|.|.| ..:..|..||:..|.|      |.|.|......|:|..|  :.::..:
Mouse  1409 --------SERESFIDRIREVIETADEKGVERERSQMASDHEQLMPTTSAPLEHGRTYNLSVPPS 1465

  Fly   832 YIGNVNGAAGKQDTLVRSPKSPL-------------LGDGPARREEDDDTADDPLHYSLNGDGGD 883
            ....|..:||::..:...|:|.|             |.:.||    ....|...|..|::.....
Mouse  1466 SAAQVVHSAGRRFIVSPVPESRLKDQFFSPSQPTIPLHEEPA----PVPVALPALGLSVSASAVS 1526

  Fly   884 GRKVYARKYSKNFNYSPDTTDYDSNCGDYDSEISPQYGSDFGLISGNGATMCDDLNNG---VISA 945
            .::.:......:|:..|.|              :|..                 |:|.   ::.|
Mouse  1527 LQQAFTEMRQAHFDPGPST--------------APPM-----------------LHNSMPPLLPA 1560

  Fly   946 TSGAPSGPGESLNCLFANNANNYTRYYAAMPVLEDGLSSGHVSDSENNLSANPMTGLLPPDLVTV 1010
            |:..||                     :|.||:...:|| .|:.|.:..|.||.....||..|.|
Mouse  1561 TTPLPS---------------------SATPVVSPPVSS-EVTSSPSLPSINPPVSSSPPPTVPV 1603

  Fly  1011 GSVKQHGQAGSNGGMMQSAGPA--------TGPYGLLGAQSPSVTAKPSISSSPSMSKEMKAAQG 1067
            .||              ::.||        ..|..:....:||....|::.::.|.
Mouse  1604 NSV--------------TSPPAQLTLPQSQVAPAVISVIPTPSTLPMPAVPTATSF--------- 1645

  Fly  1068 SHVQQQQQQQQQQQQHQPQQQQQQNQGTNVEGYFVNNTFRMGNLKLNSSMLHNASIFKNRDPELE 1132
                             ||........|.:.        .||::...|.  ...||.....|
Mouse  1646 -----------------PQTSVTVPSSTPIA--------PMGSVSGGSG--EQPSIPATSSP--- 1680

  Fly  1133 SLYTINTIQSTPPPPAPAPHRKSSIDCDNMSLLQQQQQQQQQPGQQQKQHQLQHLQQLQQQQQQS 1197
               |..|||:    |..||           |.:.....|.|.|..|.....:..:
Mouse  1681 ---TSATIQT----PQLAP-----------STIPTTTAQSQVPPLQPVTTTMPVV---------- 1717

  Fly  1198 QQQQQQQGQPQQ---PQQSQQQQQFNHGQTTSADVQSTLKDIRLCLQKTKSL--NLASGNQTRKA 1257
             |......|||.   |.||..     |.....:|.|..:.||:...:|.:||  :|.||..:.::
Mouse  1718 -QPTPVHSQPQTTTVPNQSHA-----HSVECDSDQQGKVDDIQALDKKLRSLFMDLGSGPPSAQS 1776

  Fly  1258 FDKGSLCATGDFPDPLGPVGSGTVGTAGSGGGAGTGPSLSPIWIPRTRASDDFAGKPLAGATGPT 1322
            .......||...|      |:.:..|..:..|....||..|:     .:|...||.|:.
Mouse  1777 DVTSDPTATPSVP------GTSSPTTCATPSGTPLPPSSLPL-----NSSTQSAGSPMT------ 1824

  Fly  1323 AASGTGALSNGLQPGVGVSGPSCKLSSSPVCSKPVAVAGPDFADETDVLIGQGAGGPATKPL--- 1384
                  ::.|...| ||.|  ....|.:|:...||...|||           .||.|.|:.|
Mouse  1825 ------SMGNASTP-VGYS--QTTPSKAPLTRLPVLPVGPD-----------QAGTPPTEHLPPF 1869

  Fly  1385 ---ALVDEDEDP--DTDLETDRLLGHQRLDDQGFYDESGSGKLWSTGERKTGASRLLTLGKVSPK 1444
               .|: :.:.|  |.|.:..|.|..:.:.......:|.          .||   :...|:..|.
Mouse  1870 PGPGLI-QSQQPLEDLDAQLRRALSPETVPISSVTHQSS----------LTG---MPPGGQPVPF 1920

  Fly  1445 QQQQQGASQPAGVAGGAARDTAANGKLPAAGPIGERLTGSVGVRNGPQPNGSAGGSSFLPGGGGS 1509
            ....:.|:.||  |||...     |:...:....|..|.:        |..|:..:|       |
Mouse  1921 SLDDEQAAAPA--AGGYKL-----GRFQVSVATDENTTQT--------PTSSSSSTS-------S 1963

  Fly  1510 GSSTGMAGSGASV------------PLPDLGIAAAATLP------PASGAPSTVNGGAGGTASAK 1556
            .|:|..:.|..|:            ||.|.|......||      .....|:|:    |......
Mouse  1964 SSTTSSSSSSCSLSSPENTLHRTSSPLIDTGADVVDGLPALPNQTTTQPQPTTI----GRFQVTT 2024

  Fly  1557 SAKPPSGNLINFNGPNEPQTQLTSPNPSPQHSLGEGNLLDKSNDSGSPGGSTKS-KSLHNNDSKR 1620
            ......|........:|..|....|.|:||.....||     ..:.|||....| .|..::|:..
Mouse  2025 KTDTQVGRFSVSKAQDEVTTSTLQPQPTPQTHSAVGN-----GPAQSPGSLNNSISSYFSSDNDS 2084

  Fly  1621 KSKNKEVLIEGVLFRARYLGSTQLVCEGQPTKSTRMLQAEEAVSRIKVGSGLPSPDGEVQPSTEV 1685
            :.::::...|....|.:::      .|.|...|.:..:.|...:|:          |:|.|
Mouse  2085 EFEDEDFKREVSRLRDKHM------IESQALYSRQKAEIEALFARL----------GKVPP---- 2129

  Fly  1686 DLFISTEKIMVLNTDLKEIMMDHALRTISYIADIGDLVVLMARRRFVPQDVDSTDSSGGAGTGS- 1749
                                           |.:...||..|.||..|....|:.||.|:...|
Mouse  2130 -------------------------------AMVNPPVVNPAGRRRRPTKSKSSKSSRGSSQASK 2163

  Fly  1750 -----GTHTAGHGAGSGSTPSQK--LAGG--PKGNRTPKM-----------ICHVFESE 1788
                 .|.|....:.....|:|:  ||.|  ..|..:|.:           :|..|.|:
Mouse  2164 SPVQPATSTLSAQSAPSVYPAQQAFLAPGGMMDGGSSPLLQSFKPSPSNDNLCSTFTSD 2222

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slou	NP_001262808.1	Homeodomain	546..602	CDD:459649	11/92 (12%)
Gbx2	NP_034392.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251
		Homeodomain	248..304	CDD:459649