Protein Alignment sp3 and FIG4

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: NP_055660.1
• Gene: FIG4 / 9896
• HGNCID: 16873
• Length: 907
• Species: Homo sapiens
• Alignment Length: 714
• Identity: 180/714 - (25%)
• Similarity: 279/714 - (39%)
• Gaps: 171/714 - (23%)

  Fly   197 KIFDETD---SFYFSFDCDITNNLQRH---------EAKSEESQ--------------------- 228
            :||...|   :||||:..|::::||.:         ..|||.:|
Human   152 RIFQNVDLSSNFYFSYSYDLSHSLQYNLTVLRMPLEMLKSEMTQNRQESFDIFEDEGLITQGGSG 216

  Fly   229 -----SQPDERFFWNKHMIRDLINLNDKTWILPIIQGFMQVENCVIGNECFTLALVSRRSRHRAG 288
                 |:|..::.||..::..:.:...:.|:|.||.||......:|......:.|::|||...||
Human   217 VFGICSEPYMKYVWNGELLDIIKSTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAG 281

  Fly   289 TRYKRRGVDEKGNCANYVETEQIL------SFRHHQL-SFTQVRGSVPIYWSQ------PGYKYR 340
            ||:.:||.:.:|:.||.|||||||      ||..... |:.|||||||:||||      |    :
Human   282 TRFLKRGANCEGDVANEVETEQILCDASVMSFTAGSYSSYVQVRGSVPLYWSQDISTMMP----K 342

  Fly   341 PPPRLDRGVAETQQAFELHFTKELETYGR-VCIVNLVEQSGK---EKTIGDAYADHVIKLN---- 397
            ||..||:.......| .|||.:..:.:|. :.|:|||::..|   |:.:.:.....|..||
Human   343 PPITLDQADPFAHVA-ALHFDQMFQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLP 406

  Fly   398 -NDRLIYVTFDFHDYCRGMR---FENVSALIDAVGPEAGAM-------------GFHWRDQRGMI 445
             ...::|:.:|...|.:...   .:.::.:.::|..:.|..             ...|.:..|.:
Human   407 PEHTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSILRPDEKWNELGGCV 471

  Fly   446 CN----QKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGL-SPPYTPIPEQLKSPFMVLWAN 505
            ..    |..:.|.||:|||||||..|..:||..|..||..||| ..|...........|..|:.:
Human   472 IPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFDTDAVRLFEELYED 536

  Fly   506 NGDIISRQYAGTNALKGDYTRTGERKISGM---MKDGMNSANRFFIQNFADSFRQCIIDLMQGQL 567
            :||.:|.||.|:..:....|   .|||:..   .||.|.:.:|::...|:|:.||..|:|..|..
Human   537 HGDTLSLQYGGSQLVHRVKT---YRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVF 598

  Fly   568 LRAE------DLQEDEVL--STILQIL----------TPETRPPLHGYYNPGVLGPELQLL---- 610
            ...|      :|..|..|  ...:::|          |||....|...|:..:....|:.|
Human   599 HPTEGKPHLWELPTDFYLHHKNTMRLLPTRRSYTYWWTPEVIKHLPLPYDEVICAVNLKKLIVKK 663

  Fly   611 -----ESI-----VTTSYYLARFKDSYRQATIDLMLGNQVSSESLSALGGQAG----------PD 655
                 |.|     ....|.|:.|.|::..|         ::|.:...:....|          ||
Human   664 FHKYEEEIDIHNEFFRPYELSSFDDTFCLA---------MTSSARDFMPKTVGIDPSPFTVRKPD 719

  Fly   656 EN-----DGTENAEQAKLLVEDCRRLLLGTAQYPVG--AWGLIDADPSSGDINE----TEVDTIL 709
            |.     ....|.|:|.|     :|....:|..|..  |......|.|..|..|    ::..|.:
Human   720 ETGKSVLGNKSNREEAVL-----QRKTAASAPPPPSEEAVSSSSEDDSGTDREEEGSVSQRSTPV 779

  Fly   710 LLTD--DCYIVAE---------YDSHLDKIVRFEKVQLTQVRLIELGMHQQTKIFQGSAPAHLC 762
            .:||  |...|.|         |..:|...:..|...:.. |.::||..|..:......|...|
Human   780 KMTDAGDSAKVTENVVQPMKELYGINLSDGLSEEDFSIYS-RFVQLGQSQHKQDKNSQQPCSRC 842

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	133/480 (28%)
		hSac2	663..768	CDD:463592	26/117 (22%)
FIG4	NP_055660.1	Syja_N	93..423	CDD:460545	81/275 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	707..788		20/85 (24%)