DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7956 and SYNJ1

DIOPT Version :9

Sequence 1:	NP_001036740.2	Gene:	CG7956 / 42545	FlyBaseID:	FBgn0038890	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_003886.3	Gene:	SYNJ1 / 8867	HGNCID:	11503	Length:	1612	Species:	Homo sapiens

Alignment Length:	1088	Identity:	250/1088 - (22%)
Similarity:	423/1088 - (38%)	Gaps:	236/1088 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 VGIREPRHIERRITEELHKIFDETDSFYFSFDC---DITNNLQRHEAKSEESQSQPDERFFWNK- 239
            :.:|.....|.||: |:.|:.: :.:|||::..   .:..:|..|.:..|::   .|.|||||:
Human   143 ISLRIDSSDEDRIS-EVRKVLN-SGNFYFAWSASGISLDLSLNAHRSMQEQT---TDNRFFWNQS 202

  Fly   240 ---HMIRDLINLNDKTWILPIIQGFMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGN 301
               |:....:|.:|  |:|.::.|.:::......::.....|:||.|..|||||:..||.::.|:
Human   203 LHLHLKHYGVNCDD--WLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGH 265

  Fly   302 CANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYK---YRPPPRLDRGVAETQQAFELHFTKE 363
            .||:|||||::.......||.|:|||||::|.|||.:   :|  .|:.||......||:.||...
Human   266 VANFVETEQVVYLDDSVSSFIQIRGSVPLFWEQPGLQVGSHR--VRMSRGFEANAPAFDRHFRTL 328

  Fly   364 LETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDR--LIYVTFDFHDYCRGMRFENVSALIDA 426
            ...||:..||||:.....|..:..|:..| :|.:...  :..|.||:|...:|.:.|.:.:::..
Human   329 KNLYGKQIIVNLLGSKEGEHMLSKAFQSH-LKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKP 392

  Fly   427 VGPEAGAMGFHWRDQRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPI 491
            ...:....||.:.:...:...|....|.||:|||||||.||..:|..:|..||..|||:.. ..:
Human   393 QVQKFLDYGFFYFNGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEK-PQL 456

  Fly   492 PEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFR 556
            ..:.:..|..:|:.|||.||:.||||.||:|          ...:|||..|..|....||.||.:
Human   457 VTRFQEVFRSMWSVNGDSISKIYAGTGALEG----------KAKLKDGARSVTRTIQNNFFDSSK 511

  Fly   557 QCIID-LMQGQLLRAEDLQEDEVLST---------ILQILTPETRPPL----HGYYNPGVL---- 603
            |..|| |:.|..|.::...:...|.|         .||..:.:....:    :.|..|..:
Human   512 QEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKPKKIRVCV 576

  Fly   604 -------GPELQLL--ESIVTTSYYL--------ARFKDSYRQAT----------IDLMLGNQVS 641
                   |.:.:.:  ::...|.:.|        ..|:|...:.|          ::|..||.||
Human   577 GTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGNIVS 641

  Fly   642 SESLSALGGQAGPDENDGTENAEQAKLLVEDCRRLLLGTAQYPVGAWGLIDADPSSGD-INETEV 705
            :.:           .|......|..|.:..|.:.:||.:.|. ||....:...|.... |.:..|
Human   642 AST-----------TNQKLWAVELQKTISRDNKYVLLASEQL-VGVCLFVFIRPQHAPFIRDVAV 694

  Fly   706 DTI-----------------LLL--TDDCYIVAEY--------DSHLDKIVRFEKVQLTQVRLIE 743
            ||:                 :|.  |..|::.:.:        :.:.|.|....|:.....|:
Human   695 DTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEIARKLSFPMGRM-- 757

  Fly   744 LGMHQQTKIFQGSAPAHLCLRLNYSVD----------EQEGYFHMFRSANLRFFNNMAYVIK--T 796
              :.....:|       .|...||.:|          .|:.:..:.....|....|...|.:  .
Human   758 --LFSHDYVF-------WCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFL 813

  Fly   797 QEEVAESMTSIVEMFRIALDNAGNTEVRYITGGVLQRRKSKLPTLDVPRGMPRNLSESQLVQLS- 860
            :.:|..:.|...::|....|.:........|..||.||: |.|       ..|:..:..|:..|
Human   814 EGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLWRRR-KWP-------FDRSAEDLDLLNASF 870

  Fly   861 ---SKALSNMA-GQFSKLGQTFKKPQAHPSSLAATMNPQVMRQRDSEIESGQEAEKAVFTLGRKH 921
               ||.|.... |.....|:...|...| ..:.|.::..:.   :.|.|..|...|.|..:....
Human   871 QDESKILYTWTPGTLLHYGRAELKTSDH-RPVVALIDIDIF---EVEAEERQNIYKEVIAVQGPP 931

  Fly   922 RNSNSASSTDTDEHDNSLYEPEVDSDVEIAMDKSNYNENAFL---------------PSVGIVMG 971
            ..:...|...:...:|...:..:|   |:....:::.|...:               .::.::..
Human   932 DGTVLVSIKSSLPENNFFDDALID---ELLQQFASFGEVILIRFVEDKMWVTFLEGSSALNVLSL 993

  Fly   972 NQKE-------DSPSSSDEIRHLEQKDSMCKTTEDVLTISITSVTDHVGLPTGLLENAPAIRPIT 1029
            |.||       .:..|.|.|::||::.|:.|.:              :.||:.           |
Human   994 NGKELLNRTITIALKSPDWIKNLEEEMSLEKIS--------------IALPSS-----------T 1033

  Fly  1030 PNPLICVEAHEAFDDREEGVKPVSSTSARDL--------SLPGLPTHPEANKLKQLTSPLSKLAK 1086
            .:.|:..:|..|.|...||.....|....:|        |..||.|.|.::   ..|||......
Human  1034 SSTLLGEDAEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSS---PRTSPCQSPTI 1095

  Fly  1087 NIG----LNLDPRKIATKTGVLSPTILSAENSP---------PERDPS 1121
            :.|    |.:.|.:..::|    |...||::||         |::||:
Human  1096 SEGPVPSLPIRPSRAPSRT----PGPPSAQSSPIDAQPATPLPQKDPA 1139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7956	NP_001036740.2	Syja_N	174..413	CDD:280532	77/245 (31%)
		COG5329	<197..586	CDD:227637	129/410 (31%)
		hSac2	663..768	CDD:289241	23/132 (17%)
SYNJ1	NP_003886.3	Syja_N	99..379	CDD:280532	77/245 (31%)
		INPP5c_Synj1	572..907	CDD:197332	63/366 (17%)
		DUF1866	906..1047	CDD:286093	26/171 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146098
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850