Protein Alignment sp3 and INP53

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: NP_014752.3
• Gene: INP53 / 854276
• SGDID: S000005635
• Length: 1107
• Species: Saccharomyces cerevisiae
• Alignment Length: 1007
• Identity: 237/1007 - (23%)
• Similarity: 388/1007 - (38%)
• Gaps: 264/1007 - (26%)

  Fly   194 ELHKIFDETDSFYFSFDCDITNNLQRHEAKSEESQSQP--DERFFWNKHMIRDLIN--------- 247
            ||.|:. ...|||:|.|.|:|:.|| |....:.|.|..  :|.:.||..:::::|.
Yeast   141 ELKKLL-SNGSFYYSSDFDLTSTLQ-HRGYGQHSLSTDTYEEEYMWNSFLMQEMITYRDHLDTNL 203

  Fly   248 ---LNDKTWILPIIQGFMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETE 309
               |:|:.::..:|:||.:.....:......|.::|::|..|||||:..||||::.|.||:||||
Yeast   204 KQILDDEGFLTTVIRGFAETFVSYVKKLKVALTIISKQSWKRAGTRFNARGVDDEANVANFVETE 268

  Fly   310 QILSFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLDRGVAETQQAFELHFTKELETYGRVCIVN 374
            .|:....:..:|||:|||:|::|.|......|..::.|....||..|:.|..|.:|.||.|.:||
Yeast   269 FIMYSSQYCYAFTQIRGSIPVFWEQGTSLINPRVQITRSFEATQPVFDKHIMKSVEKYGPVHVVN 333

  Fly   375 LVEQSGKEKTIGDAYADHVI---KLNNDRLIYVT-FDFHDYCRGMRFENVSALIDAVGPEAGAMG 435
            |:.....|..:...|.:|:.   |||.::.|::| ||||.......|..|..||..:.....:.|
Yeast   334 LLSTKSSEIELSKRYKEHLTHSKKLNFNKDIFLTEFDFHKETSQEGFSGVRKLIPLILDSLLSSG 398

  Fly   436 FHWRD--QRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPI-PEQLKS 497
            ::..|  ::..|..|..:||.||:|||||||:.|..|..|...:.|....|....:.| .:...|
Yeast   399 YYSYDVREKKNISEQHGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFIDDDDFVS 463

  Fly   498 PFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQCIIDL 562
            ....|||::||.||:.|.||||||..::|.|:..::|.:.|...|.:|.:|.||.|..:|..||.
Yeast   464 KHNTLWADHGDQISQIYTGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDT 528

  Fly   563 MQGQL--LRAEDLQE--DEVLSTILQILTPE-------------------TRP--------PLHG 596
            :.|:|  .:|..|.:  :|.:||.||.::.:                   |:.        |:..
Yeast   529 LLGRLPYQKAVQLYDPVNEYVSTKLQSMSDKFTSTSNINLLIGSFNVNGATKKVDLSKWLFPIGE 593

  Fly   597 YYNPGVLGPELQ-LLE----SIVTTSY------------YLARFKDSYRQATIDLMLG------- 637
            .:.|.::...|| ::|    ||:...|            .|.::.|.|....::.|..
Yeast   594 KFKPDIVVLGLQEVIELSAGSILNADYSKSSFWENLVGDCLNQYDDKYLLLRVEQMTSLLILFFV 658

  Fly   638 --------NQV-SSESLSALGGQAGPDENDGTENAEQAKLLVEDCRRLLLGTAQYPVGAWGLIDA 693
                    .|| .:...:...|.||   |.|..:..                .:|...::..:::
Yeast   659 KADKAKYVKQVEGATKKTGFRGMAG---NKGAVSIR----------------FEYGATSFCFVNS 704

  Fly   694 DPSSGDINETE----------------------VDTILLLTDDCY------------IVAEYDSH 724
            ..::|..|..|                      .|:|..|.|..|            ::.:.:.:
Yeast   705 HLAAGATNVEERRSDYESIVRGITFTRTKMIPHHDSIFWLGDMNYRINLPNEDVRRELLNQEEGY 769

  Fly   725 LDKIVRFEKVQLTQVRLIELGMHQQTKIFQGSAPAHLCLRLNYSVDEQEGYFH------------ 777
            :||::.|:  |||      ||::..: :|:|.....|..|..|..|...|.:.
Yeast   770 IDKLLHFD--QLT------LGINSGS-VFEGFKEPTLKFRPTYKYDPGTGTYDSSEKERTPSWTD 825

  Fly   778 --MFRSANL---------------------------------------RFFNNMAYVIKTQEEVA 801
              :::..||                                       |.|...     .||...
Yeast   826 RIIYKGENLLPLSYSDAPIMISDHRPVYAAYRAKITFVDDKERLSLKKRLFTEY-----KQEHPE 885

  Fly   802 ESMTSIVEMFRIALDNAGNTEVRYITGGVLQRRKSKLPTLDVPRGMP--RNLSESQLVQLSSKAL 864
            |..:.|.::..:.|||..       |.|.....:|.|..:|.....|  .:::.|..|..:|.:|
Yeast   886 EPGSLISDLLSLDLDNKS-------TDGFKSSSESSLLDIDPIMAQPTASSVASSSPVSSASASL 943

  Fly   865 SNMAGQFSKLGQT-FKKPQAHP---------------SSLAATMNPQVMRQRDSEIESGQEAEKA 913
            ..:..|.|...:| .|||...|               :|...:..||......|.:....:..|
Yeast   944 QPVRTQNSSQSRTPIKKPVLRPPPPPAHKSVSAPAPSTSKEKSPTPQTSTASLSSVTKNIQENK- 1007

  Fly   914 VFTLGRKHR---------------NSNSAS--STDTDEHDNSLYEPEVDSDVEIAMDKSNYNENA 961
              .|.:..|               .||.||  |:..|     ||....:| ...|.|.......|
Yeast  1008 --PLAQNRRIPPPGFSQNILTPKSTSNLASPMSSKVD-----LYNSASES-TRSAQDARQQTPTA 1064

  Fly   962 FLPSVGI------VMGNQKEDSPSSSDEIRHL 987
            |..|..:      ::|::....|....::.|:
Yeast  1065 FAASRDVNGQPEALLGDENPIEPEEKAKLNHM 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	139/413 (34%)
		hSac2	663..768	CDD:463592	21/138 (15%)
INP53	NP_014752.3	COG5329	1..603	CDD:227637	144/463 (31%)
		INPP5c_ScInp51p-like	566..858	CDD:197324	46/319 (14%)