Protein Alignment sp3 and FRA3

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: NP_176736.2
• Gene: FRA3 / 842869
• AraportID: AT1G65580
• Length: 1101
• Species: Arabidopsis thaliana
• Alignment Length: 1089
• Identity: 190/1089 - (17%)
• Similarity: 332/1089 - (30%)
• Gaps: 339/1089 - (31%)

  Fly   115 PTHSVSTSNNNNASVPSSGG-----------GSSKSTKLFEGMNKTWGAVKSAGNTIKNTTQQAA 168
            |..|::.|...:....|.||           |.|.|.|:.|   :...|:....:.|......:|
plant   229 PVLSIAISAYGDIWSGSEGGALKVWPWDGALGKSLSLKMEE---RHMAALAVERSYIDPRNMVSA 290

  Fly   169 NLATKQVKSSVGIREPRHIERRI--------------TEELHKIFD--------ETDSFYFSFDC 211
            |.....:.|.|......|...|:              |.:|.|:|:        ..:|.|..|..
plant   291 NGFANTLTSDVTFLVSDHTRARVWSASPLTFAIWDARTRDLIKVFNIDGQLENRPENSVYPDFGS 355

  Fly   212 DITNNLQRHEAKSEESQSQPDERFFWNKHMIRDLINLNDKTWILPIIQGFMQ-VENCVIGNECFT 275
            :....::...:|.|::||.                            .||.| ..|.::|
plant   356 EEEGKMKVTASKKEKAQSS----------------------------LGFFQRSRNAIMG----- 387

  Fly   276 LALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYR 340
                        .....||...:.|.|.:..:||.|: .....:.:|.....:.:.|.
plant   388 ------------AADAVRRAATKGGFCDDSRKTEAIV-ISVDGMIWTGSSNGILMRWD------- 432

  Fly   341 PPPRLDRGVAETQQAFELHFTKELETYGRVCI---------------VNLVEQSGKEKTIGD--A 388
                   |.....|.|      ..|:.|.:|:               |.:.:..|  |.:|.  |
plant   433 -------GNGNCLQEF------AYESSGILCMFTFCSRLWVGYSNGTVQVWDLEG--KLLGGWVA 482

  Fly   389 YADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALIDAVGPEAGAMGF-------------HWRD 440
            ::..|||:........|...|...||....:...|.:.:..|.....|             .|..
plant   483 HSGPVIKMAIGAGYLFTLANHGGIRGWNVTSPGPLDNVLRAELAGKEFLYSRIENLKILAGTWNV 547

  Fly   441 QRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIPEQLKSPFMVLWAN 505
            ..|.......|..:.|.    .|.|....:|...:|.....|.:|.....:..: .||....|.
plant   548 GEGRASTDSLVSWLGCA----ATGVEIVVVGLQEVEMGAGVLAMSAAKETVGLE-GSPLGQWWL- 606

  Fly   506 NGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQCIIDLMQGQLLRA 570
              |:|.:    |......:.|.|.|:::|::
plant   607 --DMIGK----TLDEGSSFVRVGSRQLAGLL---------------------------------- 631

  Fly   571 EDLQEDEVLSTILQILTPETRPPL-------------HGYYNPGVLGPELQLLESIV--TTSYYL 620
                       |...:..:.:|.:             ....|.|.:|..|::.:.::  ...::.
plant   632 -----------ICVWVRHDLKPHVGDVDAAAVPCGFGRAIGNKGAVGVRLRMYDRVLCFVNCHFA 685

  Fly   621 ARFKD-SYRQATIDLMLGNQVSSESLSALGGQAGPDENDGTENAEQAKLLVEDCRRLLLGTAQYP 684
            |..:. :.|.|..|.:......|...|:|        |.|...|.....:......|.:.|
plant   686 AHLEAVNRRNADFDHVYRTMTFSRQSSSL--------NAGVAGASFGVTMPRGGNALGVNT---- 738

  Fly   685 VGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAE--YDSHLDKIVR------FEKVQL-TQVR 740
                  |:|.|..     :|.|.::.|.|..|.:.:  ||...|.|.:      .||.|| |:
plant   739 ------IEARPEL-----SEADMVIFLGDFNYRLDDITYDETRDFISQRCFDWLREKDQLHTE-- 790

  Fly   741 LIELGMHQQTKIFQGSAPAHLCLRLNYSVDEQE----GYFHMFRSANLRFFNNMAYVIKTQEEVA 801
             :|.|     .:|||...|.:.....|..:..:    ||....:.....:.:.:.|....:...|
plant   791 -MEAG-----NVFQGMREAIIRFPPTYKFERHQAGLAGYDSGEKKRIPAWCDRILYRDNKKHLGA 849

  Fly   802 E-----SMTSIVEMFRIALD--NAGNTEVRYITGGVLQRRKSKLPTLDVPRGMPRNLSESQLVQL 859
            |     .:.|.:..:...::  ::.:..||.:....:.|....:          |......::.
plant   850 ECSLDCPVVSSISQYDACMEVTDSDHKPVRCVFSVKIARVDESV----------RRQEYGNIIN- 903

  Fly   860 SSKALSNMAGQFSKLGQTFKKPQAHPSSLAATMNPQVMRQRDS---EIESGQEAEKAVFTL---G 918
            |:|.:..:.|:.||:          |.::.:| |..:::.:||   .|.:..|...|.|.:   |
plant   904 SNKKIKVLLGELSKV----------PETIVST-NNIILQNQDSTILRITNKSEKNIAFFKIICEG 957

  Fly   919 RKHRNSNSASSTDTDEHDN----SLYEPEVDSDVEIAMDKSNYNENAFLPSVGIVMGNQ------ 973
            :      |....|...||:    |...|:.   :|::            |..|.:..||
plant   958 Q------SKIEEDGQAHDHRARGSFGFPQW---LEVS------------PGTGTIKPNQIAEVSV 1001

  Fly   974 -KEDSPSSSDEIRHLEQKDSMCKTTEDVLTISITSVTDHVGLPTGLLENAPAIRPITPNPLICVE 1037
             .||.|:..:.:..:.| :|.|:.|.|...|.:..|  |....|...::...:|.       |..
plant  1002 HLEDFPTVEEFVDGVAQ-NSWCEDTRDKEVILVLVV--HGRFSTETRKHRIRVRH-------CPR 1056

  Fly  1038 AHEAFDDREEGVKPVSSTSARDLSLPGLPTHPEAN------KLKQLTSP 1080
            ...|.:...:|.|    ||.:..:|.....|..:|      :||.|.||
plant  1057 GGPAKNHFNDGTK----TSGQINALHRSDYHQLSNTLDVVEQLKNLHSP 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	65/427 (15%)
		hSac2	663..768	CDD:463592	26/113 (23%)
FRA3	NP_176736.2	WD40	117..513	CDD:441893	62/354 (18%)
		WD40 repeat	186..221	CDD:293791
		WD40 repeat	230..264	CDD:293791	7/33 (21%)
		WD40 repeat	413..442	CDD:293791	5/48 (10%)
		WD40 repeat	449..481	CDD:293791	5/33 (15%)
		INPP5c	538..884	CDD:197308	70/433 (16%)
		Motile_Sperm	919..1043	CDD:459882	32/148 (22%)