DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7956 and Synj2

DIOPT Version :9

Sequence 1:	NP_001036740.2	Gene:	CG7956 / 42545	FlyBaseID:	FBgn0038890	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001106842.1	Gene:	Synj2 / 84018	RGDID:	69436	Length:	1496	Species:	Rattus norvegicus

Alignment Length:	1166	Identity:	260/1166 - (22%)
Similarity:	427/1166 - (36%)	Gaps:	342/1166 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 FYFSFD----C-DITNNLQRHEAKSEESQSQPDERFFWNKHMIRDL----INLNDKTWILPIIQG 260
            |||::.    | |:|...|    |..:..|:....||||:.:...|    :|.:|  |:|.:|.|
  Rat   129 FYFAWPNDGACFDLTIRAQ----KQGDDCSEWGTSFFWNQLLHVPLRQHQVNCHD--WLLKVICG 187

  Fly   261 FMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVR 325
            .:.:......::.....|:||.|..|||.|:..|||::.|:.:|:|||||.:.......||.|:|
  Rat   188 VVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIYMDDGVSSFVQIR 252

  Fly   326 GSVPIYWSQPGYKYRPPP-RLDRGVAETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAY 389
            ||||::|.|||.:..... ||.||:.....|||.|.....|.||:..:|||:...|.|:.:..|:
  Rat   253 GSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAF 317

  Fly   390 ADHVIKLNNDRLIY----------VTFDFHDYCRGMRFENVSALIDAVGPEAGAMGFHWRDQRGM 444
                     .:|::          :.||||.:.:|.:.|.:..|:   .|:   :..|| |..|:
  Rat   318 ---------KKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLL---RPQ---LKLHW-DDFGV 366

  Fly   445 ICN--------QKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIPEQLKSPFMV 501
            ...        ||...|:||:|||||||.||..|...||..||..|||:.  .||.::....|..
  Rat   367 FAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNS--KPITDRFVESFKA 429

  Fly   502 LWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQCIID-LMQG 565
            :|:.||..:|:.:.|:.||:      |:.|: |.:|||..|.:|....||.|..:|..|. |:.|
  Rat   430 MWSLNGHGLSKVFTGSRALE------GKAKV-GKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVG 487

  Fly   566 QLLRAEDLQEDEVL--STILQILTPETRPPLHGYYNPGVLGPELQLLESIVTTSYYLARFK---- 624
            .:...|...:..:|  :|.|..|....:..|.|..: |...|  ::|:::.........||
  Rat   488 DVYNEESTDKGRMLLDNTALLGLGSNKQNSLSGMLD-GKATP--RILKAMTERQSEFTNFKRIQI 549

  Fly   625 ----------DSYRQ---ATIDL--------MLGNQVSSE------SLSALGGQ------AGPDE 656
                      ..:|.   .|.:|        .|...|.|:      .:.|:|.:      ||...
  Rat   550 AMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGGPADIFAVGFEEMVELSAGNIV 614

  Fly   657 NDGTEN----AEQAKLLVEDCRRLLLGTAQYPVGAWGLIDADPSSGD-INETEVDTI-------- 708
            |..|.|    .||.:..:....|.:|.|:...||....|...|.... |.:..:||:
  Rat   615 NASTTNRKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKA 679

  Fly   709 -----------LLLTDDCYIVA-----------------------------------------EY 721
                       ...|..|:|.:                                         ::
  Rat   680 GNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYREITHKLSFPSGRNIFSHDYVFWCGDF 744

  Fly   722 DSHLD----------------KIVRFEKVQLTQVR-LIELGMHQQT-------KIFQGSA----- 757
            :..:|                |::.|:::||.:.. .|....|:.|       |...|||
  Rat   745 NYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAYDTS 809

  Fly   758 -----PAH----LCLRLNYSVDEQEGYFHMFRS-----ANLRFF---NNMAYVIKTQEEVAE--S 803
                 ||.    |..|..:..|:..|..::..|     ||:|..   ..:.|..:.:.:.::  .
  Rat   810 DKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDANIRHTWSPGTLKYYGRAELQASDHRP 874

  Fly   804 MTSIVEMFRIALDNAGNTEVRYITGGVLQRRKSKL-----------------PTLDVPRGMPRNL 851
            :.:|||:           ||:.:..|..:|...::                 |||:.....|.:|
  Rat   875 VLAIVEV-----------EVQEVDVGARERVFQEVSSVQGPLDATVIVNLQSPTLEERNEFPEDL 928

  Fly   852 SESQLVQL-----------------------SSKALSNMAGQFSKLGQTFKKPQAHPSSLAATMN 893
             .::|:|.                       |..|||.:.....|:.....|.:.........:.
  Rat   929 -RTELMQTLGNYGTIILVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLEGLR 992

  Fly   894 PQVMRQRDSEIESGQEAEKAVFTLGRKHRNSNSASSTDTDEHDNSLYEPE----VDSDVEIAMDK 954
            .:::|:|||.......|...:........:.:..|..|..|.|......|    |.||.|:..|.
  Rat   993 EELIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDVLEDDEDYLADEFGQPVVSDSELGGDD 1057

  Fly   955 SNYNENAFLPSVGIVMGNQKEDSPSSSDEIRHLEQKDSMCKTTEDVLTISITSVTDHVGLPTGLL 1019
            |:...:|..|:         ..||:.:.:.:|...||.     .|::|:.:.            |
  Rat  1058 SSDTMSASTPA---------SKSPALAKKKQHPTYKDD-----ADLMTLKLE------------L 1096

  Fly  1020 ENAPAIRPITPNPLICVEAHEAFDDREEGVKPVSSTSARDLSLPGLPTHPEANKLKQLTSPLSKL 1084
            |.|...|..:|                          :|.||:|..|..|.         |..:.
  Rat  1097 EVAGNFRHRSP--------------------------SRSLSVPNRPRPPH---------PPQRP 1126

  Fly  1085 AKNIGLNLDPRKIATKTGVLSPT------ILSAENSP--PERDPSSRDHLLELWEAEKCKT 1137
            ....||.:  :|.|:...:.|.|      :.:|:..|  |::.|.:|..:.:.:..::.||
  Rat  1127 PPPTGLMV--KKSASDASISSGTHGQYSILQTAKLLPGAPQQPPKARTGISKPYNVKQIKT 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7956	NP_001036740.2	Syja_N	174..413	CDD:280532	72/227 (32%)
		COG5329	<197..586	CDD:227637	131/411 (32%)
		hSac2	663..768	CDD:289241	31/203 (15%)
Synj2	NP_001106842.1	Syja_N	61..342	CDD:280532	72/227 (32%)
		EEP	547..878	CDD:294334	51/330 (15%)
		DUF1866	889..1025	CDD:286093	20/136 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1047..1083		11/44 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1100..1149		15/85 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1357
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1393..1413
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1442..1461
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1468..1496
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339895
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850