Protein Alignment sp3 and ocrl

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: XP_009289414.1
• Gene: ocrl / 777716
• ZFINID: ZDB-GENE-061110-61
• Length: 961
• Species: Danio rerio
• Alignment Length: 637
• Identity: 121/637 - (18%)
• Similarity: 219/637 - (34%)
• Gaps: 220/637 - (34%)

  Fly   550 NFADSFRQCIIDLMQGQLLRAEDLQEDEVLSTI-------LQILTPETRPPLHGYYNPG--VLGP 605
            :|..|..|||. .::|..:|:.. :|..:||.:       |.||:           ||.  ||.|
Zfish     5 SFGISESQCIA-TVRGHEIRSGQ-KEPRLLSLLECSGQFKLDILS-----------NPDAIVLSP 56

  Fly   606 ELQLLESIVTTSYYLARFKDSYRQATIDLMLGNQVSSESLSALGGQAGPD-----ENDG-----T 660
            ..||  ||...:::.. .:::.....||:   :.:|......|.|:..|:     ::||     .
Zfish    57 VSQL--SIPINNHFRI-IREAEEALLIDI---DSISKTVRIRLRGERTPELLLELQDDGQTQSFL 115

  Fly   661 ENAEQAKLLVEDCRRLLLGTAQYPVGAWGLIDADP----------SSGDINETEV-------DTI 708
            |:..:||   :...|..|.....||....:.|..|          .|.:||.:.:       .|.
Zfish   116 EHVTKAK---QQAERSSLPRKMEPVVPAPVKDCVPVPPQRGTSKSFSNNINNSTLANPSNTDSTR 177

  Fly   709 LLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVRLIEL------------------------GMHQQ 749
            .|.||     ..::.:.:.:::.|:.:..|.||:..                        ...::
Zfish   178 SLATD-----FGFEENFNHVLKVEEKKNKQNRLVAQREPPPPPIPPLPPRKGTNTSLTGPATKER 237

  Fly   750 TKIFQGSAPAHLCLRLNY-SVDEQEGYFHMFRSANLRFFNNMAYVIKTQEEVAESMTSIVEMFRI 813
            ....|.:.|    :|..: |||....:.....::.:|                ::|.|
Zfish   238 PPSVQNATP----VRNEFQSVDRSVSWSESPSNSTIR----------------QAMMS------- 275

  Fly   814 ALDNAGNTEVRYITGGVLQRRKSKLPTLDVPRGMPRNLSESQLVQLSSKALSNMAGQFSKLGQTF 878
              .:||:.|      |:|:.|.||              .|.:.|.:  |......|.::..||:
Zfish   276 --SHAGSRE------GLLKYRLSK--------------KEKEYVDI--KNFKFFVGTWNVNGQS- 315

  Fly   879 KKPQAHPSSLAATMNPQVMRQRDSEIESGQEAEKAVFTLGRKHRNSNSASSTDTDEHDNSLYEPE 943
                  |.|   ::.|.:....|         ...|:.||.:..:.::.:....|.....|:...
Zfish   316 ------PDS---SLGPWLSSDPD---------PPDVYALGFQELDLSTEAFFYMDSSKEQLWVDA 362

  Fly   944 VDSDVEIAMDKSNYNENAFLPSVG--IVMGNQKEDSPSSSDEIRHLEQKDSMCKTTEDVLTISIT 1006
            |:..:.   .|:.|.:...:..||  :|:..:||    ..|:||.:
Zfish   363 VERGLH---QKARYIQVRIIRLVGMMLVVYIKKE----HKDQIREI------------------- 401

  Fly  1007 SVTDHVGLPTGLL-----ENAPAIRPITPNPLIC-VEAHEA-----FDDREEGVKPV-SSTSARD 1059
             .::.||  |||:     :...|:|.:..|...| |.:|.|     |:.|.:..|.: :..|...
Zfish   402 -ASESVG--TGLMNKMGNKGGVAVRFVFHNTSFCFVNSHLAAHVDDFERRNQDYKDICARMSFHL 463

  Fly  1060 LSLP--GLPTH---------------PEANKLKQLTS--PLSKLAKNIGLNL 1092
            |..|  .:..|               |:|.::|:|.:  .|.:|.:...|||
Zfish   464 LEYPPVSIVKHDVVIWLGDLNYRLCLPDAGEVKRLIAEKELRRLQEYDQLNL 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	11/42 (26%)
		hSac2	663..768	CDD:463592	22/146 (15%)
ocrl	XP_009289414.1	PH_OCRL1	13..122	CDD:270182	28/127 (22%)
		INPP5c_INPP5B	302..593	CDD:197327	51/262 (19%)
		RhoGAP_OCRL1	728..956	CDD:239845