Protein Alignment sp3 and inpp5f

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: XP_005156933.1
• Gene: inpp5f / 570007
• ZFINID: ZDB-GENE-041111-194
• Length: 1126
• Species: Danio rerio
• Alignment Length: 1282
• Identity: 425/1282 - (33%)
• Similarity: 611/1282 - (47%)
• Gaps: 296/1282 - (23%)

  Fly     1 MEVFQTDSHYIFVKRDKSLWWHRRTSEFSIKAGWDLSSVDDIECIGVTHGIVGVISLPNVYEPHL 65
            ||:||...|||....|.:||..|:....:::...||....:..|:|:..||:|.:.|.......|
Zfish     1 MELFQAKDHYILQSGDNALWCSRKDGSMAVRPATDLLLAWNPVCLGLVEGIIGKMQLHVDLPLGL 65

  Fly    66 VVVKEASAVGVLYPPHLVYKIKSICI--LSADDP-DTDLPNCTKHTKSNQSTPTHSVSTSNNNNA 127
            :::::.:.||.|...|.||||..|.:  ||.|:| |.:|..|.||                :...
Zfish    66 ILIRQKALVGQLPGDHKVYKITKIVVIPLSEDEPQDLELELCKKH----------------HFGI 114

  Fly   128 SVPSSGGGSSKSTKLFEGMNKTWGAVKS-AGNTIKNTTQQAANLATKQVKSSVGIREPRHIERRI 191
            :.|.....|...||.   :.||...:|| .|..||.....|.     |||.:   :|...:|||:
Zfish   115 NKPERITQSPDETKF---LMKTLSQIKSNVGAPIKKKYSPAF-----QVKEN---KEKERLERRL 168

  Fly   192 TEELHKIFDETDSFYFSFDCDITNNLQRHEAKSEESQ---SQPDERFFWNKHMIRDLINLNDKT- 252
            .:||:|||.::||||:|...|:||.:||.....:..|   .:.|:|||||||||:||::|....
Zfish   169 LDELYKIFMDSDSFYYSLTYDLTNTVQRQGELGKSDQPLWKRVDDRFFWNKHMIKDLVDLQAPQV 233

  Fly   253 --WILPIIQGFMQVENCVIG-NE-----------------C-------FTLALVSRRSRHRAGTR 290
              |::||||||:|||..|:. ||                 |       ||:||:|||||||||.|
Zfish   234 DFWVIPIIQGFVQVEELVVNYNESSDEERSSPETPLQEPTCVDDIHPRFTVALISRRSRHRAGMR 298

  Fly   291 YKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLDRGVAETQQA 355
            |||||||..|:.||||||||::....|.|||.|.|||||::|||.||:|.|.||:::|..||...
Zfish   299 YKRRGVDTDGHVANYVETEQLIHVHSHTLSFVQTRGSVPVFWSQAGYRYNPRPRIEKGERETMPY 363

  Fly   356 FELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENV 420
            |..||.||:|||.::.|:|||:|:|:||.|||||...|:..||..|.||:||||::||||:||||
Zfish   364 FASHFEKEVETYKKLVIINLVDQNGREKIIGDAYLKQVLLYNNPNLTYVSFDFHEHCRGMKFENV 428

  Fly   421 SALIDAVGPEAGAMGFHWRDQRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLS 485
            ..|.||:......|.:.|.||.|:||.|:.:||||||||||||||||.||.:.::|.||.|||:.
Zfish   429 QTLTDAIYDIITDMRWAWVDQAGVICQQEGIFRVNCMDCLDRTNVVQAAIARVIMEQQLKKLGVM 493

  Fly   486 PPYTPIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQN 550
            ||..|:|.:....:.|:||||||.||||||||.|||||:|||||||::|:||||:|||||
Zfish   494 PPEQPLPLKCYRIYQVMWANNGDTISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANR----- 553

  Fly   551 FADSFRQCIIDLMQGQLLRAEDLQEDEVLSTILQILTPETRPPLHGYYNPGVLGPELQLLESIVT 615
                                                                             
Zfish   554 ----------------------------------------------------------------- 553

  Fly   616 TSYYLARFKDSYRQATIDLMLGNQVSSESLSALGGQAGPDEND-----GTENAEQAKLLVEDCRR 675
              |||.||:|:||||.||||:|:.|:.:..|....:...:|.:     |.:  ||..||::...:
Zfish   554 --YYLNRFRDAYRQAVIDLMMGHPVTEDLYSIFSKEKEHEEKEKESQRGAQ--EQVSLLLQTYMQ 614

  Fly   676 LLLGTAQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVR 740
            |||...:...|.|.|||.|||..|....:||.:|||::..|.||.||...||:.:::::.|..:.
Zfish   615 LLLPDDEKFHGGWALIDCDPSLIDATHKDVDVLLLLSNSAYYVAYYDEEADKVNQYQRLSLEGLE 679

  Fly   741 LIELGMHQQTKIFQGSAPAHLCLRLNYSVDEQEGYFHMFRSANLRFFNNMAYVIKTQEEVAESMT 805
            .||:|  .:..:|  ..|.:.|:||:|...|..||||..||...          ..:::..:::.
Zfish   680 KIEIG--PEPTLF--GKPKYCCMRLHYKNGETSGYFHTLRSVTR----------NPEDDGKDTLQ 730

  Fly   806 SIVEMFRIALDNAGNTEVRYITGGVLQRRKSKLPTLDV------------PRGMPRNLS-----E 853
            .|.||.||.....| .:|: :....|:||.|| |..|:            ..|:.:..|     .
Zfish   731 CIAEMLRITKQAMG-LDVQ-VVEKKLERRHSK-PHEDIMGIQGKAVDQVLGSGLAQGKSFFLNKF 792

  Fly   854 SQLVQLSSKALSNM-AGQFSKLGQ--TFKKPQAHPSSLAATMNPQVMRQRDSEIESGQEAEKAVF 915
            |.|.|...:..:|: .|.|..||:  ||.||:...:.|...::..:.:. ||.:|:
Zfish   793 STLNQKVKQTKTNVNIGNFKPLGKLGTFSKPEVKVNFLKPNLHMNLWKS-DSSLET--------- 847

  Fly   916 TLGRKHRNSNSASSTDTDEHDNSLYEPEVDSDVEIAMDKSNYN----------ENA--FLPSVGI 968
                  .:||:.|....|...:|         .||:.|..:||          ||.  .|||.||
Zfish   848 ------HDSNTGSGALKDHGPHS---------EEISSDSDSYNSDEQPCSGSRENVDYVLPSCGI 897

  Fly   969 VMGNQKEDSPSSS----------------------DEIR-HLEQKDSMCKTTEDVLTISITS--- 1007
            |....:..|.|.|                      |.:. ..:|........|:.:.|...:
Zfish   898 VASAPRLGSRSQSIGSVEIAVPSVIRVTGCDEKTMDSLSVAADQSPGAASEAEEAILIDFGTPID 962

  Fly  1008 ------VTDHVGLPTGLLEN-APAIRPITPNPLICVEA-----HE----------AFDDREEG-- 1048
                  |.|....|..:.|. |||.:|..|...:..:|     |.          ..:....|
Zfish   963 VYCHQFVQDAKTKPIEVFEEVAPAPKPQGPQVPLAPDAKLGSSHSQNQLPRPSQLEVESNVHGAN 1027

  Fly  1049 ---VKPVSSTSA--RDLSLPGL--PTHPEANKLKQLTSPLSKLAKNIGLNLDPRKIA--TKTGV- 1103
               |:||.|.::  ...||.|:  |:..::|. .::.||.:|:..::      .::|  |:.|:
Zfish  1028 LLTVQPVGSATSCGSQKSLEGITGPSSADSNG-SRVVSPFAKIRSSM------VQVASLTQAGLT 1085

  Fly  1104 --LSPTILSAENSPPERDPSSRDHLLELWEAE------KCKTKLIAL 1142
              ::..:...:.||   :|   |.:.|..|.|      :|:|::|.:
Zfish  1086 QGINFAVAKVQKSP---EP---DAVNETQENELRAMFTQCQTRIIQI 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	208/419 (50%)
		hSac2	663..768	CDD:463592	37/104 (36%)
inpp5f	XP_005156933.1	COG5329	65..574	CDD:227637	262/607 (43%)
		hSac2	602..703	CDD:463592	37/106 (35%)