Protein Alignment sp3 and inpp5b

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: XP_009290335.3
• Gene: inpp5b / 563543
• ZFINID: ZDB-GENE-110411-228
• Length: 907
• Species: Danio rerio
• Alignment Length: 985
• Identity: 168/985 - (17%)
• Similarity: 307/985 - (31%)
• Gaps: 351/985 - (35%)

  Fly     3 VFQTDSHYIFVKRDKSLWWHRRTS----------------EFSIKAGWDLSSVDDIECIG----- 46
            |.|...|.:|:      :.|||.:                :||:.   ::||.|::..:|
Zfish    39 VRQNKEHALFI------YSHRRMAITGEDVTLGQIIPISYDFSVV---EVSSPDELAVVGADTRV 94

  Fly    47 -VTHGIVGVISLPNVYEPH----LVVVKEA-SAVGVLYPPHLVYKIKSICILSADDPDTD-LPNC 104
             ||. :...:.|...:..|    |..|..| |.|...||              .::|..| |...
Zfish    95 RVTF-LEEELELKLPFGSHTRLFLSEVNRAWSDVCQQYP--------------KEEPKFDWLTKY 144

  Fly   105 TKHTKSNQS------------TPTHSVSTSNNNNASVPSSGGGSSKSTKLFEGMNKTWGAVKSAG 157
            .|.:|..:|            :.......::..|:|.......|::...| :...|..|.||.
Zfish   145 RKVSKGARSLRKSIGATTVKMSQMKKAERAHTANSSALKKEDESARGDAL-QSQEKVKGEVKD-- 206

  Fly   158 NTIKNTTQQAANLATKQVKSSVGIREPRHIERRITEELHKIFD-----ETDSFYFSFDCDITNNL 217
            :.|:|:....:|.|........|:|     :..|..||.|..|     |..||:..     |.|:
Zfish   207 DLIRNSQPVLSNKAQMLGMPQFGLR-----DNLIKCELLKNEDAYTYIENYSFFLG-----TYNV 261

  Fly   218 QRHEAKSE------ESQSQPD-------------ERFFWNKHMIRDLINLNDKTWILPIIQG--- 260
            .....|..      .:.|.||             |.|.:|.       ...:..|:|.:.:|
Zfish   262 NGQTPKESLSPWLASTASPPDFYLIGFQELDLSKEAFLFND-------TPKEPEWMLAVYKGLHP 319

  Fly   261 ---FMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFT 322
               :..|:...:........:.:..:.|.:....:..|....|...|
Zfish   320 DAKYALVKLVRLVGIMLLFYVKAEHAPHISEVEAETVGTGVMGRMGN------------------ 366

  Fly   323 QVRGSVPIYWSQPGYKYRPPPRLDRGVAETQQAFELHFTKELETYGRVCIVN--LVEQSGKEKTI 385
              :|:|.|                        .|:.|.:.       :|:||  |.
Zfish   367 --KGAVSI------------------------RFQFHNSD-------ICVVNSHLA--------- 389

  Fly   386 GDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFEN-------VSALIDAVGPEAGAMGF------- 436
              |:.:...:.|.        ||.|.||.::|..       ::.|...:....|.:.:
Zfish   390 --AHTEEFERRNQ--------DFKDICRRIQFRQEDPTLPPLTILKHNIVLWLGDLNYRISDLEV 444

  Fly   437 -HWRDQRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLS-------PPYT---- 489
             |.:|    :.::|....::..|.|.|.           ::.::|.:|.:       |.|.
Zfish   445 DHVKD----LISKKDFETLHTYDQLKRQ-----------MDEEVVFVGFTEGEIDFQPTYKYDTG 494

  Fly   490 ----PIPEQLKSPF---MVLWANNGDIISRQYAGTNALKGDYTRTGERK-ISGMMKDGMNSAN-R 545
                ...|:.:.|.   .:||... .|....|.....||     |.:.| :|.:::.|:...| .
Zfish   495 SDQWDTSEKCRVPAWCDRILWRGK-SIKQLHYQSHMTLK-----TSDHKPVSSLLEIGIKVVNEE 553

  Fly   546 FFIQNFADSFRQCIIDLMQGQLLRAEDLQEDEVLSTILQILTPETRPPLHGYYNPGVLGPELQLL 610
            .:.:.|.:..||  ||.::...:.:..|.|.|.....::.:..:.|...  .:|.|.:..:.:.:
Zfish   554 SYKRTFEEIVRQ--IDRLENDCIPSVSLSEREFHFQDVKFMQHQARTVT--VHNDGQVPCQFEFI 614

  Fly   611 ESIVTTSY------------YLARFKDSYRQATIDLMLGNQVSSESLSALGGQAGPDENDGTENA 663
            :.:...:|            :||      :.|::|:.|...|:..:        .|:.|.|.:..
Zfish   615 QKLDEPAYCKPWLTANPAKGFLA------QGASVDIDLEVFVNRHT--------APELNAGLQQL 665

  Fly   664 EQAKLLVEDCRR----LLLGTAQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYDSH 724
            |.  :||....|    .:..|..|....:|             :.:..:.||.:.
Zfish   666 ED--ILVLHLERGKDYFISITGSYLPSCFG-------------SSLSALCLLREP---------- 705

  Fly   725 LDKIVRFEKVQLTQVRLIELGMHQQTKIFQGS-APAHLCLRLNYSVDEQEGYFHMFRSANLRFFN 788
                  .:.:.|..:|  ||.:...:.:...: .|..:...:...||      |:||.|
Zfish   706 ------IQDMPLESIR--ELSVKSNSPVIDSADKPQEIPKEIWMMVD------HLFRYA------ 750

  Fly   789 NMAYVIKTQEEVAE--SMTSIVEMFRIALDNAGNTEVRYITGGVLQRRKSKLPTLDVPRGMPRNL 851
                  |.||::.:  .:.|..|..|..||          ||           .||...|...::
Zfish   751 ------KKQEDLFQQPGLRSEFEEIRDCLD----------TG-----------CLDTLPGSNHSV 788

  Fly   852 SESQLVQLSS 861
            :|:.|:.|.:
Zfish   789 AEALLLFLDA 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	72/455 (16%)
		hSac2	663..768	CDD:463592	14/109 (13%)
inpp5b	XP_009290335.3	INPP5B_PH	1..143	CDD:465268	27/127 (21%)
		INPP5c_INPP5B	253..545	CDD:197327	59/394 (15%)
		PapD-like	574..>648	CDD:373355	12/81 (15%)
		RhoGAP_OCRL1	680..892	CDD:239845	32/189 (17%)