DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7956 and SH2D1A

DIOPT Version :9

Sequence 1:	NP_001036740.2	Gene:	CG7956 / 42545	FlyBaseID:	FBgn0038890	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_002342.1	Gene:	SH2D1A / 4068	HGNCID:	10820	Length:	128	Species:	Homo sapiens

Alignment Length:	88	Identity:	18/88 - (20%)
Similarity:	29/88 - (32%)	Gaps:	24/88 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   756 SAPAHLCLRLNYSVDEQEGYFHMFR---------------SANLRFFNNMAYVI----KTQEEVA 801
            |.|...||.:.|     .||.:.:|               ..:.|:|..:..:|    |..:.:.
Human    36 SVPGVYCLCVLY-----HGYIYTYRVSQTETGSWSAETAPGVHKRYFRKIKNLISAFQKPDQGIV 95

  Fly   802 ESMTSIVEMFRIALDNAGNTEVR 824
            ..:...||....|....|.|.:|
Human    96 IPLQYPVEKKSSARSTQGTTGIR 118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7956	NP_001036740.2	Syja_N	174..413	CDD:280532
		COG5329	<197..586	CDD:227637
		hSac2	663..768	CDD:289241	4/11 (36%)
SH2D1A	NP_002342.1	SH2_SAP1a	2..104	CDD:198263	13/72 (18%)
		Interaction with FYN SH3 domain. /evidence=ECO:0000250\|UniProtKB:O88890	67..92		4/24 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	106..128		4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930