Protein Alignment sp3 and Synj

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: NP_569729.1
• Gene: Synj / 37517
• FlyBaseID: FBgn0034691
• Length: 1218
• Species: Drosophila melanogaster
• Alignment Length: 1255
• Identity: 292/1255 - (23%)
• Similarity: 461/1255 - (36%)
• Gaps: 343/1255 - (27%)

  Fly   137 SKSTKLFEGMNKTWGAVKSAGNTIKNTTQQAANLATKQ--------------------------- 174
            |..:.|.|..||: .::....:.:...|||..::..||
  Fly    17 SPHSVLLEHRNKS-DSILFESHAVALLTQQETDVIRKQYTKVCDAYGCLGALQLNAGESTVLFLV 80

  Fly   175 -VKSSVGIREPRHIE-RRITE-----------------ELHKIFDETDSFYF------------- 207
             |...|.:.:...|| .|||:                 |:.|:.: :.:|||
  Fly    81 LVTGCVSMGKIGDIEIFRITQTTFVSLQNAAPNEDKISEVRKLLN-SGTFYFAHTNASASASGAS 144

  Fly   208 SFDCDITNNLQRHEAKSEESQSQPDERFFWNK----HMIRDLINLNDKTWILPIIQGFMQVENCV 268
            |:..|||...||.:...|     .|.|||||:    |::|  ..::.::|:|..:.|.::|....
  Fly   145 SYRFDITLCAQRRQQTQE-----TDNRFFWNRMMHIHLMR--FGIDCQSWLLQAMCGSVEVRTVY 202

  Fly   269 IGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWS 333
            ||.:....|::||.|..|||||:..||.:::|..||:|||||::.......|:.|.|||||::|.
  Fly   203 IGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQVIYVDGDVTSYVQTRGSVPLFWE 267

  Fly   334 QPGYKY-RPPPRLDRGVAETQQAFELHFTKELETYGRVCIVNLVEQS------GKEKTIGDAYAD 391
            |||.:. ....:|.||...:..||:.|.:...:.||...:|||:..|      |:.....:....
  Fly   268 QPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSKEGEAMLSNEFQRH 332

  Fly   392 HVIKLNNDRLIYVTFDFHDYCRGMRFENVSAL---IDAVGPEAGAMGFHWRDQRGMICNQK-SVF 452
            |.:..:.| :.:|.||:|..|||..|..::.|   |.|.|...|.  ||  ...|.:..:: .|.
  Fly   333 HGMSAHKD-VPHVVFDYHQECRGGNFSALAKLKERIVACGANYGV--FH--ASNGQVLREQFGVV 392

  Fly   453 RVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIPEQLKSPFMVLWANNGDIISRQYAGT 517
            |.||:|||||||.|||.:|...|..||..|.:......| .:.:..|..:|.|||:.:|:.||||
  Fly   393 RTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNI-SRFEEIFRQMWINNGNEVSKIYAGT 456

  Fly   518 NALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQCIID-LMQGQLLRAEDLQEDEVL-- 579
            .|::|          ...:.||..||.|....|..|:.:|..|| |:.|..|.:|......:|
  Fly   457 GAIQG----------GSKLMDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLP 511

  Fly   580 -------STILQIL----TPETRPPLH----GYYNPGVLGPELQLLESIVTTSYYLARFKDSYRQ 629
                   :|:|:.|    |...||.:.    |.||  |.|.  :...|||        ||||...
  Fly   512 SNMLHAPTTVLRELCKRYTEYVRPRMARVAVGTYN--VNGG--KHFRSIV--------FKDSLAD 564

  Fly   630 ATID---------LMLGNQVSSE-----SLSALGGQAGPDENDG---TENAEQAKLLVEDCRRLL 677
            ..:|         |:..|..|..     .:.|:|.:...|.|..   ..:.:.|||..|:.::.:
  Fly   565 WLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTI 629

  Fly   678 -------LGTAQYPVGAWGLIDADP--------------------SSGDINETEVDTILLLTDDC 715
                   |.|.|..||....|...|                    ::|:.....:..:|..|..|
  Fly   630 SRDNDYVLLTYQQLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMC 694

  Fly   716 YIVAEYDSHLDKIV--RFEKVQLTQVRLIELG--MHQQTKIFQGSAPAHLCLRLNYSVD-EQEGY 775
            ::.|.:.:...::.  ..:..::|:.....:|  :.....:|       .|...||.:| |::..
  Fly   695 FVCAHFAAGQSQVAERNADYAEITRKLAFPMGRTLKSHDWVF-------WCGDFNYRIDMEKDEL 752

  Fly   776 FHMFRSANLRFFNNMAYVIKTQE-----------EVAESMTSIVEMFRIALDNAGNTEVRYITGG 829
            ....|:.:|........:.|.||           |:....|...::|....|.:........|..
  Fly   753 KECVRNGDLSTVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDR 817

  Fly   830 VLQRRKSKLPTLDVPRGMPRNLSESQLVQLSSKALSNMAGQFSKLGQTFKKPQAHPSSLAATMNP 894
            ||.||:..|...|                .::.|.:  .|:....|::..|...|...:|..
  Fly   818 VLWRRRKALAEGD----------------FAASAWN--PGKLIHYGRSELKQSDHRPVIAII--- 861

  Fly   895 QVMRQRDSEI-ESGQEAEKAVF-----TLGRK------HRNSNSASSTDTDEHDNSLYEPEVDSD 947
                  |:|| |..|:..:|||     .||..      |...:||:.   ||...::|:..|.|.
  Fly   862 ------DAEIMEIDQQRRRAVFEQVIRDLGPPDSTIVVHVLESSATG---DEDGPTIYDENVMSA 917

  Fly   948 VEIAMDKS------NYNENAFLPSV-----GIVMGNQKEDSPSSSDEIRHLEQKD---------S 992
            :...:.|.      .|.|:....:.     .:...::|.......|.|..|:.||         .
  Fly   918 LITELSKMGEVTLVRYVEDTMWVTFRDGESALNASSKKSIQVCGLDLILELKSKDWQHLVDSEIE 982

  Fly   993 MCKTTEDVLTIS-------ITSVT-------------------------------DHVGLPTGLL 1019
            :|.|....|..:       :.::|                               .|||:.:.:.
  Fly   983 LCTTNTIPLCANPVEHAQLLQAITPELPQRPKQPPTRPPARPPMPMSPKNSPRHLPHVGVISIVP 1047

  Fly  1020 ENA-------PAIRPITPNPL---ICVEAHEAFD--------DREEGVKPVSSTSARDLSLP--- 1063
            :.|       |..:|:.|:||   :......|.|        ...|.|...||||:...:.|
  Fly  1048 KPAKPPMPPQPQSQPLIPSPLQPQVAPPRPPAMDTTPSSKSQSPTELVSASSSTSSSGKTSPTAP 1112

  Fly  1064 ----GLPTHPEANKLKQLTSPLSKLAKNIGLNLDPRKIATKTGVLS------------------- 1105
                |.||.|...:.||.| |:|...:.:|...||....|.....|
  Fly  1113 AVLSGPPTPPRQMQSKQAT-PVSTPTRQVGSPKDPIPSDTAYETASNIYEEIQEDVPAPRHPPPA 1176

  Fly  1106 --PTILSAENSPPERDPSSR 1123
              |.::.|...||...|:.|
  Fly  1177 GPPPVIGAPMGPPPPLPNRR 1196

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	135/426 (32%)
		hSac2	663..768	CDD:463592	21/135 (16%)
Synj	NP_569729.1	COG5329	61..493	CDD:227637	136/455 (30%)
		INPP5c_Synj	538..863	CDD:197323	66/370 (18%)
		DUF1866	862..1008	CDD:286093	31/148 (21%)