Protein Alignment sp3 and INPP5B

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: NP_005531.2
• Gene: INPP5B / 3633
• HGNCID: 6077
• Length: 913
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 110/533 - (20%)
• Similarity: 190/533 - (35%)
• Gaps: 148/533 - (27%)

  Fly   694 DPSSGDINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVRLIE------LGMHQQTKI 752
            |||...:..:..|.||.|.|..|.:.|.|        .|||:    :|||      |..:.|.||
Human   428 DPSLPPLTISNHDVILWLGDLNYRIEELD--------VEKVK----KLIEEKDFQMLYAYDQLKI 480

  Fly   753 -------FQGSAPAHLCLRLNYSVDEQEGYFH--------------MFRSAN---LRFFNNMAYV 793
                   |:|.....|..:..|..|.....:.              :::..|   |.:.::||
Human   481 QVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMA-- 543

  Fly   794 IKTQEEVAESMTSIVEM-FRIALDNAGNTEVRYITGGVLQRRKSKLPTLDVPRGMPRNLSESQL- 856
            :||.:.  :.::|:.:: .|:..|......:..|...:.:...:.:|::        :||:.:.
Human   544 LKTSDH--KPVSSVFDIGVRVVNDELYRKTLEEIVRSLDKMENANIPSV--------SLSKREFC 598

  Fly   857 ------VQLSSKALSNMAGQFSKLGQTFKKP----------QAHP--------SSLAATMNPQVM 897
                  :||..::.:...||.....:...||          .|:|        |.:...:...|.
Human   599 FQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLNANPSRGFLLPDSDVEIDLELFVN 663

  Fly   898 RQRDSEIESGQEAEKAVFTL----GRKHRNSNSA----SSTDTDEHDNS-LYEPEVDSDVEIAM- 952
            :...:::.||::..:.:..|    |:.:..|.|.    |...:..|... :.||.:|..:|...
Human   664 KMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLETISE 728

  Fly   953 ----------DKSNYNENAFLPS-----VGIVMGN--QKED---SPSSSDEIRHLEQKDSMCKTT 997
                      |.|..:....:|.     |..:..|  |:||   .|....|..|:  :|.:....
Human   729 LTLMPVWTGDDGSQLDSPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRSEFEHI--RDCLDTGM 791

  Fly   998 EDVLTISITSVTDHVGLPTGLLENAPAIRPITPNPLICVEA-HEAFD--DREEGVKPVSSTSARD 1059
            .|.|:.|..||.:.:.|   .||:       .|.|:||... |...:  ......|.|.||
Human   792 IDNLSASNHSVAEALLL---FLES-------LPEPVICYSTYHNCLECSGNYTASKQVIST---- 842

  Fly  1060 LSLPGLPTHPEANKLKQLTSPLSKLAKNIGLN-LDPRKIATKTGVLSPTILSAENSPPERDPSSR 1123
                 ||.. ..|....|.:.|.:|.||...| ||...:|:..|.|   :|        |:|:..
Human   843 -----LPIF-HKNVFHYLMAFLRELLKNSAKNHLDENILASIFGSL---LL--------RNPAGH 890

  Fly  1124 DHLLELWEAEKCK 1136
            .. |::.|.:|.:
Human   891 QK-LDMTEKKKAQ 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637
		hSac2	663..768	CDD:463592	24/86 (28%)
INPP5B	NP_005531.2	INPP5B_PH	1..146	CDD:465268
		INPP5c_INPP5B	265..558	CDD:197327	33/145 (23%)
		RhoGAP_OCRL1	692..912	CDD:239845	57/245 (23%)