Protein Alignment sp3 and Inpp5b

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: NP_001094225.1
• Gene: Inpp5b / 362590
• RGDID: 1311511
• Length: 916
• Species: Rattus norvegicus
• Alignment Length: 1037
• Identity: 190/1037 - (18%)
• Similarity: 329/1037 - (31%)
• Gaps: 351/1037 - (33%)

  Fly   257 IIQGFMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSF 321
            :::|    |.|||..:.......||:||.....||:         ..|.|:...:..:.|.:::.
  Rat    11 LVEG----EYCVIAVQGVLCKGDSRQSRLLGLVRYR---------LENDVQEHALFLYTHRRMAI 62

  Fly   322 T-------QVRGSVPIYWSQPGYKYRPPPRL---------DRGVAETQQAFELHFTKELETY--- 367
            |       |:   ||:.......:..|...|         ....||.:..|:|.|.....|:
  Rat    63 TGDDVALDQI---VPLSKDFMLEEVSPDGELYILGSDVTVQLTTAELRLVFQLPFGSHTRTFLQE 124

  Fly   368 -GRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALIDAVGPE- 430
             .|.|       .|.:....|.                  :|...||....|:     :|..|:
  Rat   125 VARAC-------PGFDPETRDP------------------EFLWLCRHRCAES-----EAESPKP 159

  Fly   431 ---------------AGAMGFHWRDQ----RGMI-CNQKSVFRVNCMDCLDRTNVVQTAIGKAVL 475
                           .|..|::....    ||:: .:|.|..|     |.|:.
  Rat   160 REWNSDPGTRSGFAPIGGGGYNVDSSRPNGRGLLPLDQSSGAR-----CPDKP------------ 207

  Fly   476 ESQLVKLGLSPPYTPIPEQLKSPFMVLWANNGDIISRQYAGTN---------ALKGDYTRTGERK 531
            |:.|.:...|.  ..|.:.::|..:.: ::...|:|.|..|..         ..:|:||
  Rat   208 ENSLTRQNRSK--AEITDMVRSSTITV-SDKAHILSMQKFGLRDTMVRSHLLQKEGEYT------ 263

  Fly   532 ISGMMKDGMNSANRFFIQNF----------ADSFRQCI--------------------IDLMQGQ 566
                           :||||          ..|.::|:                    :||.:..
  Rat   264 ---------------YIQNFRFFVGTYNVNGQSPKECLRPWLSSDTKAPDVYCVGFQELDLSKEA 313

  Fly   567 LLRAEDLQEDEVLSTILQILTPETRPPLHGYYNPGVLGPELQLLESIVTTSY-------YLARFK 624
            ....:..:|:|....:.:.|.|:.:          ....:|..|..|:...|       |::..:
  Rat   314 FFFHDTPKEEEWFKAVSESLHPDAK----------YAKVKLIRLVGIMLLLYVKQEHAAYISEVE 368

  Fly   625 DSYRQATIDLMLGN--------QVSSESLSALGGQAGPDENDGTENAEQAKLLVED-CRRLLLGT 680
            .......|...:||        |:.:.|:..:.......    ||..|:......| |.|:...
  Rat   369 AETVGTGIMGRMGNKGGVAIRFQLHNTSICVVNSHLAAH----TEEYERRNQDYRDICSRMQFS- 428

  Fly   681 AQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVRLIE-- 743
                       ..|||...:..::.|.||.|.|..|.:.|.|        .|||:    :|:|
  Rat   429 -----------QVDPSLPPLTISKHDVILWLGDLNYRIEELD--------VEKVK----KLVEEK 470

  Fly   744 ----LGMHQQTKI-------FQGSAPAHLCLRLNYSVDEQEGYFH--------------MFRSAN 783
                |..|.|.||       |:|.....:..:..|..|.....:.              ::|..|
  Rat   471 AFHTLYAHDQLKIQVAAKTVFEGFTEGEITFQPTYKYDTGSDNWDTSEKCRAPAWCDRVLWRGKN 535

  Fly   784 LRFFNNMAYV-IKTQEEVAESMTSIVEM-FRIALDNAGNTEVRYITGGVLQRRKSKLPTLDVPRG 846
            :...:..::: :||.:.  :.::|:.|: .|:.     |.|:...|...:.|...|:...::|
  Rat   536 ISQLSYQSHMSLKTSDH--KPVSSVFEIGVRVV-----NEELYRKTLEEIVRSLDKMENANIP-- 591

  Fly   847 MPRNLSESQL-------VQLSSKALSNMAGQF---------------------SKLGQTFKKPQA 883
             ...||:.:.       :||.:...:...||.                     :|..:.|..|.:
  Rat   592 -SVTLSKREFCFENVKYMQLQTATFTIHNGQVPCEFEFINKPDEETYCKQWLTAKPSRGFLLPDS 655

  Fly   884 HPSSLAATMNPQVMRQRDSEIESGQEAEKAVFTLGRKHRNSNSASSTDTDEHDNSLY-------- 940
            |   :...:...|.:...:::.||::..:.:..| ..||..:...|. |..:..|.:
  Rat   656 H---VEIELELFVNKATATKLNSGKDTIEDILVL-HLHRGKDYFLSV-TGNYLPSCFGSPIHTLC 715

  Fly   941 ---EPEVD-----------SDVEIAMDKSNYNENAFLPS-----VGIVMGN--QKED---SPSSS 981
               ||.:|           ..|:.|.|:|...:...:|.     |..:..|  |:||   .|...
  Rat   716 YMREPILDLPLKIVNELTLMTVQTADDRSQLEKPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLR 780

  Fly   982 DEIRHLEQKDSMCKTTEDVLTISITSVTDHVGLPTGLLENAPAIRPITPNPLICVEAHEA---FD 1043
            .|..|:  :|.:.....|.|..:..||.:.:.|   .||:       .|.|:||..|:.:   ..
  Rat   781 PEFEHI--RDCLDTGMIDHLCANNHSVAEALLL---FLES-------LPEPVICYSAYHSCLECS 833

  Fly  1044 DREEGVKPVSSTSARDLSLPGLPTHPEANKLKQLTSPLSKLAKNIGLN-LDPRKIATKTGVL 1104
            ......|.|.||         |||. ..|....|.:.|.:|.||...| ||...:|:..|.|
  Rat   834 GSHTASKQVIST---------LPTF-HKNVFSYLMAFLQELLKNSAKNHLDENILASIFGSL 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	67/408 (16%)
		hSac2	663..768	CDD:463592	27/118 (23%)
Inpp5b	NP_001094225.1	INPP5B_PH	1..144	CDD:465268	31/173 (18%)
		INPP5c_INPP5B	268..561	CDD:197327	55/332 (17%)
		RhoGAP_OCRL1	695..915	CDD:239845	51/214 (24%)