Protein Alignment sp3 and INPP5J

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: NP_001271214.1
• Gene: INPP5J / 27124
• HGNCID: 8956
• Length: 1006
• Species: Homo sapiens
• Alignment Length: 370
• Identity: 74/370 - (20%)
• Similarity: 111/370 - (30%)
• Gaps: 118/370 - (31%)

  Fly   835 KSKLPTLDVPRGMPRNLSESQLVQLSSKALSNMAGQFSKLGQTFKKP--------QAHPSSLAAT 891
            ::.|.:|.:|:|:.:                  .|..||:..:|:.|        .:.|....|.
Human    15 RAGLGSLPMPQGVAQ------------------TGAPSKVDSSFQLPAKKNAALGPSEPRLALAP 61

  Fly   892 MNPQVMRQRDSE-----------------IESGQEAEKAVFTLGRKHRNSN-------------S 926
            :.|:......||                 ...||:...|       ||:|:             |
Human    62 VGPRAAMSASSEGPRLALASPRPILAPLCTPEGQKTATA-------HRSSSLAPTSVGQLVMSAS 119

  Fly   927 ASSTDTDEHDNSLYEPEVDSDVEIAMDKSNYNEN---AFLPSVGIVMGNQKEDSPSS-------- 980
            |..........|:..|   :.:.:.|..|....:   ...|::.....:||::.|:|
Human   120 AGPKPPPATTGSVLAP---TSLGLVMPASAGPRSPPVTLGPNLAPTSRDQKQEPPASVGPKPTLA 181

  Fly   981 ----SDEIRHLEQKDSMCKTTEDV-------------LTISITSVTDHVGLPTGLLENAPAIRPI 1028
                |..:...||...:..|...|             ...|..|....||..:....:|||
Human   182 ASGLSLALASEEQPPELPSTPSPVPSPVLSPTQEQALAPASTASGAASVGQTSARKRDAPA---- 242

  Fly  1029 TPNPLICVEAH---EAFDDREEGVKPVSSTSARDLSLPGLPTHPEANKLKQ----LTSPLSKLAK 1086
             |.||...|.|   .|......|..|...||......|.....|||.....    |..|...|..
Human   243 -PRPLPASEGHLQPPAQTSGPTGSPPCIQTSPDPRLSPSFRARPEALHSSPEDPVLPRPPQTLPL 306

  Fly  1087 NIGLNLDPRKIATKT-GVLSPTIL----SAENSP-----PERDPS 1121
            ::|..  |.:..|.: |:||||..    |.:..|     |.|.||
Human   307 DVGQG--PSEPGTHSPGLLSPTFRPGAPSGQTVPPPLPKPPRSPS 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637
		hSac2	663..768	CDD:463592
INPP5J	NP_001271214.1	PHA03247	<3..396	CDD:223021	74/370 (20%)
		INPP5c_INPP5J-like	423..730	CDD:197328
		SKICH	741..839	CDD:465482