DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7956 and Synj2

DIOPT Version :9

Sequence 1:	NP_001036740.2	Gene:	CG7956 / 42545	FlyBaseID:	FBgn0038890	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001106824.1	Gene:	Synj2 / 20975	MGIID:	1201671	Length:	1479	Species:	Mus musculus

Alignment Length:	1263	Identity:	280/1263 - (22%)
Similarity:	432/1263 - (34%)	Gaps:	425/1263 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 SVGIREPRHIERRITEELHKIFDETDS---------------FYFSFD----C-DITNNLQRHEA 222
            |||......|.:....||:.:.:|...               |||::.    | |:|...|
Mouse    87 SVGRIPDAEIYKITATELYPLQEEAKEEDRLPTLKKILSSGVFYFAWPNDGACFDLTIRAQ---- 147

  Fly   223 KSEESQSQPDERFFWNK--HMIRDLINLNDKTWILPIIQGFMQVENCVIGNECFTLALVSRRSRH 285
            |..:..|:....||||:  |:......:|...|:|.:|.|.:.:......::.....|:||.|..
Mouse   148 KQGDDGSEWGTSFFWNQLLHVPLRQHQVNCHNWLLKVICGVVTIRTVYASHKQAKACLISRISCE 212

  Fly   286 RAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYRPPP-RLDRGV 349
            |||.|:..|||::.|:.:|:|||||.:.......||.|:|||||::|.|||.:..... ||.||:
Mouse   213 RAGARFLTRGVNDDGHVSNFVETEQTIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGL 277

  Fly   350 AETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIY----------V 404
            .....|||.|.....|.||:..:|||:...|.|:.:..|:         .:|::          :
Mouse   278 EANAPAFERHMVLLKEQYGKQVVVNLLGSRGGEEVLNRAF---------KKLLWASCHAGDTPMI 333

  Fly   405 TFDFHDYCRGMRFENVSALIDAVGPEAGAMGFHWRDQRGMICN--------QKSVFRVNCMDCLD 461
            .||||.:.:|.:.|.:..|:   .|:   :..||.| .|:...        ||...|:||:||||
Mouse   334 NFDFHQFAKGRKLEKLENLL---RPQ---LQLHWED-FGVFAKGENVSPRFQKGTLRMNCLDCLD 391

  Fly   462 RTNVVQTAIGKAVLESQLVKLGLSPPYTPIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTR 526
            |||.||..|...||..||..|||:.  .||.::....|..:|:.||..:|:.:.|:.||:
Mouse   392 RTNTVQCFIALEVLHLQLESLGLNS--KPIIDRFVESFKAMWSLNGHSLSKVFTGSRALE----- 449

  Fly   527 TGERKISGMMKDGMNSANRFFIQNFADSFRQCIIDLM------------QGQLLRAEDLQEDEVL 579
             |:.|: |.:|||..|.:|....||.|..:|..|.|:            :|::|    |....:|
Mouse   450 -GKAKV-GKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRML----LDNTALL 508

  Fly   580 ST--ILQILTPE----------------------------------------TRPPLHGYY---- 598
            :|  ||:.:|..                                        ..|.|.|..
Mouse   509 ATPRILKAMTERQSEFTNFKRIQIAVGTWNVNGGKQFRSNLLGTAELTDWLLDAPQLSGAVDSQD 573

  Fly   599 -----------------------------NPGVLGPELQ----------LLESIVTTSYYLARFK 624
                                         |..:.|.:||          ||.|.......|..|.
Mouse   574 DGSPADVFAIGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFV 638

  Fly   625 DSY-----RQATIDLMLGNQVSSESLSALGGQAGPDENDG--------------------TENAE 664
            ..|     |...||.:         .:.:||:||   |.|                    |....
Mouse   639 RPYHVPFIRDVAIDTV---------KTGMGGKAG---NKGAVGIRFQLHSTSFCFVCSHLTAGQS 691

  Fly   665 QAKLLVEDCRRLLLGTAQYPVGA---------WGLIDADPSSGDINETEVDTILLLTDDCYIVAE 720
            |.|...||.|. :.....:|.|.         |        .||.| ..:|  |...:..|.|..
Mouse   692 QVKERNEDYRE-ITHKLSFPSGRNIFSHDYVFW--------CGDFN-YRID--LTYEEVFYFVKR 744

  Fly   721 YDSHLDKIVRFEKVQLTQVRLIELGMHQQTKIFQ-----------------GSA----------P 758
            .|  ..|::.|:::||.:         ...|||:                 |||          |
Mouse   745 QD--WKKLMEFDQLQLQK---------SSGKIFKDFHEGAVNFGPTYKYDVGSAAYDTSDKCRTP 798

  Fly   759 AH----LCLRLNYSVDEQEGYF--------------HMFRSANLRFFNNMAYVIKTQEEVAESMT 805
            |.    |..|..:..|:..|..              |.:....|:::..    .:.|......:.
Mouse   799 AWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDPQIRHTWSPGTLKYYGR----AELQASDHRPVL 859

  Fly   806 SIVEMFRIALDNAGNTEVRYITGGVLQRRKSKL-----------------PTLDVPRGMPRNLSE 853
            :|||:           ||:.:..|..:|...::                 |||:.....|.:| .
Mouse   860 AIVEV-----------EVQEVDVGARERVFQEVSSVQGPLDATVVVNLQSPTLEEKNEFPEDL-R 912

  Fly   854 SQLVQL-----------------------SSKALSNMAGQFSKLGQTFKKPQAHPSSLAATMNPQ 895
            ::|:|.                       |..|||.:.....|:.....|.:.........:..:
Mouse   913 TELMQTLGNYGTIILVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLEGLREE 977

  Fly   896 VMRQRDSEIESGQEAEKAVFTLGRKHRNSNSASSTDTDEHDNSLYEPE----------VDSDVEI 950
            ::|:|||.......|...:.      ..:...||.|.:...:.|.|.|          |.||.|:
Mouse   978 LLRKRDSMAPVSPTANSCLL------EENFDFSSLDYESEGDVLEEDEDYLVDGFGQPVVSDSEL 1036

  Fly   951 AMDKSN-----------------------YNENAFLPSVG---IVMGNQKEDSPSSSDEI----- 984
            ..|.|:                       |.::|.|.::.   .|.||.:..|||.|..:
Mouse  1037 GGDNSSDTMSSLTPASKSPALAKKKQHPTYKDDAHLVTLKQELEVAGNFRHRSPSRSLSVPNRPR 1101

  Fly   985 -RHLEQKDS-----MCKTTEDVLTISITSVTDHVGLPTG-LLENAPAIRPITPNPLICVEAHEAF 1042
             .|..|:..     |.|.:....:||..:...:..|.|. ||..||...|.....:
Mouse  1102 PPHPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTAKLLPGAPQQPPKARTGI--------- 1157

  Fly  1043 DDREEGVKPVSSTSARDLSLP---------GLP-THPEANKLKQLTSPLSKLAKNIGLNLDPRKI 1097
             .:...||.:.:|:|::....         |:| :.|.|..|:...|  ||....:|....||:.
Mouse  1158 -SKPYNVKQIKTTNAQEAEAAIRCLLEASGGVPESAPGAIPLRNQGS--SKPEATLGPPALPRRP 1219

  Fly  1098 ATKTGVL-SPTI-------LSAENSPPE 1117
            |.:...: .||:       |..||..|:
Mouse  1220 APRVPTMKKPTLRRTGKPMLPEENFEPQ 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7956	NP_001036740.2	Syja_N	174..413	CDD:280532	78/267 (29%)
		COG5329	<197..586	CDD:227637	133/443 (30%)
		hSac2	663..768	CDD:289241	30/144 (21%)
Synj2	NP_001106824.1	Syja_N	61..342	CDD:280532	78/267 (29%)
		EEP	530..861	CDD:294334	58/369 (16%)
		DUF1866	872..1008	CDD:286093	22/142 (15%)
		CEND1	1290..>1405	CDD:292305
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836230
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850