Protein Alignment sp3 and sac-2

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: NP_001252206.1
• Gene: sac-2 / 173236
• WormBaseID: WBGene00012353
• Length: 783
• Species: Caenorhabditis elegans
• Alignment Length: 1010
• Identity: 284/1010 - (28%)
• Similarity: 437/1010 - (43%)
• Gaps: 236/1010 - (23%)

  Fly     1 MEVFQTDSHYIFVKRDKSLWWHRRTSEFSIKAGWDLSSVD-DIECIGVTHGIVGVISLPNVYEPH 64
            |.::.|.:..|..::.:.:.:.||..:...|....|..:| |:...|....::|.||..   |.|
 Worm     1 MIIYTTPTALILEEQGERVEFDRRNGKVLEKPEESLEILDQDVVLCGNVEFLIGKISFD---EQH 62

  Fly    65 -LVVVKEASAVGVLYPPHLVYKIKSICILSADDPDTDLPNCTKHTKSNQSTPTHSVSTSNNNNAS 128
             |..|.::|.|.                            |.:.|.:..|   ||:.......|.
 Worm    63 FLFFVVDSSVVA----------------------------CYRGTSAESS---HSIRRIERVIAI 96

  Fly   129 VPSSGGGSSKSTKLFEGMNKTWGAVKSAGNTIKNTTQQAANLATKQVKSSVGIREPRHIERRITE 193
            ...|.|...||.           ....:|..:|..|::......::|..:    |||   ..:.:
 Worm    97 NVKSDGSVIKSQ-----------ITPGSGTKLKQGTEKIMKFFAEKVTKA----EPR---PALLD 143

  Fly   194 ELHKIFDETDSFYFSFDCDITNNLQRHEAKSEESQSQPDERFFWNKHMIRDL--INLNDKTWILP 256
            ::.|:|:::..|||....|:|.:.|::..|.|...|  ::.|||||.|:.:|  ..::|| :..|
 Worm   144 DVLKLFNDSKDFYFCRSRDVTISSQKYFEKREAHTS--EDSFFWNKRMVGNLGEAKISDK-FTCP 205

  Fly   257 IIQGFMQVENCVIG---NECFTLALVSRRSRHRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQ 318
            |:||::......|.   |...|:.::||||..|||.||.|||:||..|.||:||||.||:...|:
 Worm   206 IMQGYVATSQLEITDQINAYLTITIISRRSTRRAGARYLRRGIDEASNVANFVETELILNIFEHE 270

  Fly   319 LSFTQVRGSVPIYWSQPGYKYRPPPRLDRGVAETQQAFELHFTKELETYGRVCI-VNLVEQSGKE 382
            |||.|.|||:|::|||.|:|||||..::|.|.||...|..||.:....|....: |:||:|.|:|
 Worm   271 LSFVQCRGSIPVFWSQRGFKYRPPLIINRSVEETHGVFTEHFKRLKAHYDTPLVAVSLVDQRGRE 335

  Fly   383 KTIGDAYADHVIKLNNDRLIYVTFDFHDYCRGMRFENVSALIDAVGPEAGAMGFHWRDQRG-MIC 446
            ..:...:.:|.:|.:::.:.:.:||.|.:|||:.|:.:..||.::......:||.|.|:.| ::.
 Worm   336 LPLAQRFLEHCVKADDNDVTFFSFDLHQHCRGLNFQKLQTLISSMEETLKTIGFCWVDKTGEVVQ 400

  Fly   447 NQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIPEQLKSPFMVLWANNGDIIS 511
            :||.|.|.||:|||||||:||..|...|:..|..:||:..|....||.|......:||:|||:||
 Worm   401 SQKGVVRTNCIDCLDRTNLVQGQISLFVVLQQAQRLGIFGPLCEPPEVLVQTMQTMWADNGDVIS 465

  Fly   512 RQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQCIIDLMQGQLLRAEDLQED 576
            .|||||.|||||.||.||||:.|:||||.|||:|
 Worm   466 TQYAGTAALKGDVTRNGERKLMGVMKDGYNSASR------------------------------- 499

  Fly   577 EVLSTILQILTPETRPPLHGYYNPGVLGPELQLLESIVTTSYYLARFKDSYRQATIDLMLGNQVS 641
                                                     |||...||:.||..|:::.|...:
 Worm   500 -----------------------------------------YYLTHTKDAQRQKAINIVTGQTEA 523

  Fly   642 SESLSALGGQAGPDENDGTENAEQAKLLVEDCRRLLLGTAQYPVGAWGLIDADPSSGDINETEVD 706
            .|:       |..:||: .|..|....:|.:..:.|:.|.|..:..||||:|..||     .|:|
 Worm   524 DEN-------AEEEENE-KEEEENISRMVTETIQFLVPTQQTVIAGWGLINAFQSS-----DEID 575

  Fly   707 TILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQVRLIELGMHQQTKIFQGSAPAHLCLRLNYSVDE 771
            |:::||.....:..|:...:|:...:.|.|..:..|:.|.         |.....|.||    :.
 Worm   576 TVVILTRSNLYIVTYEIDGEKMTDVQIVALEDINTIQTGT---------SGNNRQCARL----ET 627

  Fly   772 QEGYFHMFRSANLRFFNNMAYVIKTQEEVAESMTSIVEMFRIALDNAGNTEVRYITGGVLQRRKS 836
            .||.| ::|.:.:|.|||.|..:|:.||..|.::|:.|..::     |...:....|.|:...|.
 Worm   628 LEGVF-IWRPSTVRLFNNTAIRLKSLEEANEYISSVAEQIQV-----GRNMLTGAEGSVVPVAKI 686

  Fly   837 KLPTLDVPRGMPRNLSESQLVQLSSKALSNMAGQFSKLGQTFKKPQAHPSSLAATMNPQVMRQRD 901
            .:|.:.|.|                |:::.|...|.|:.:..|     ||||
 Worm   687 TIPQMSVHR----------------KSMAAMGALFGKIKRVGK-----PSSL------------- 717

  Fly   902 SEIESGQEAEKAVFTLGRKHRNSNSASSTDTDEHDNSLYEPEVDSDVEIAMDKSNYNENAFLPSV 966
                                  |.|||:..|.:      .||.|.:...|..||::     |.:.
 Worm   718 ----------------------SKSASTISTAQ------LPETDGNESDASQKSDH-----LMTK 749

  Fly   967 GIVMGNQKEDSPSSSDEIRHLEQKDSMCKTTEDVL 1001
            .:.|...|.||| ..:....|....|.|:|...:|
 Worm   750 ILKMSQFKSDSP-QPEPFSSLLPAISECQTKISLL 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	154/395 (39%)
		hSac2	663..768	CDD:463592	27/104 (26%)
sac-2	NP_001252206.1	COG5329	25..520	CDD:227637	193/621 (31%)
		hSac2	549..>615	CDD:463592	20/70 (29%)