Protein Alignment sp3 and Inpp5b

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: XP_006502867.1
• Gene: Inpp5b / 16330
• MGIID: 103257
• Length: 994
• Species: Mus musculus
• Alignment Length: 742
• Identity: 145/742 - (19%)
• Similarity: 255/742 - (34%)
• Gaps: 246/742 - (33%)

  Fly   544 NRFFIQNF----------ADSFRQCI--------------------IDLMQGQLLRAEDLQEDEV 578
            |..:||||          ..|.::|:                    :||.:......:..:|:|.
Mouse   339 NYTYIQNFRFFVGTYNVNGQSPKECLRPWLSHSALAPDVYCVGFQELDLSKEAFFFHDTPKEEEW 403

  Fly   579 LSTILQILTPETRPPLHGYYNPGVLGPELQLLESIVTTSYYLARFKDSYRQATIDLMLG------ 637
            ...:.:.|.|:.:                          |...:|   .|...|.|:|.
Mouse   404 FKAVSESLHPDAK--------------------------YAKVKF---VRLVGIMLLLYVKQEHA 439

  Fly   638 ---NQVSSESL-SALGGQAGPDENDG-----------------------TENAEQAKLLVED-CR 674
               ::|.:|:: :.:.|:.|   |.|                       ||..|:......| |.
Mouse   440 AYISEVEAETVGTGIMGRMG---NKGGVAIRFQLHNTSICVVNSHLAAHTEEYERRNQDYRDICS 501

  Fly   675 RLLLGTAQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYD-SHLDKIVRFEKVQLTQ 738
            |:     |:|       ..|||...:...:.|.||.|.|..|.:.|.| ..:.|:|. ||...|
Mouse   502 RM-----QFP-------QVDPSQPPLTINKHDVILWLGDLNYRIEELDVGKVKKLVE-EKAFQT- 552

  Fly   739 VRLIELGMHQQTK-------IFQGSAPAHLCLRLNYSVDEQEGYFH--------------MFRSA 782
                 |..|.|.|       ||.|.....:..:..|..|.....:.              :::..
Mouse   553 -----LYAHDQLKIQVAARTIFDGFTEGEITFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGK 612

  Fly   783 N---LRFFNNMAYVIKTQEEVAESMTSIVEM-FRIALDNAGNTEVRYITGGVLQRRKSKLPTLDV 843
            |   |.:.::||  :||.:.  :.::|:.:: .|:.     |.|:...|...:.|...|:...::
Mouse   613 NITQLSYQSHMA--LKTSDH--KPVSSVFDIGVRVV-----NEELYRKTLEEIVRSLDKMENANI 668

  Fly   844 PRGMPRNLSESQL-------VQLSSKAL----SNMAGQF-----------------SKLGQTFKK 880
            |   ...||:.:.       :||.:::.    |.:..||                 ::..:.|..
Mouse   669 P---SVTLSKREFCFENVKYMQLQTESFTIHNSQVPCQFEFINKPDEESYCKQWLTARPSKGFLL 730

  Fly   881 PQAHPSSLAATMNPQVMRQRDSEIESGQEAEKAVFTL----GRKHRNSNSA----SSTDTDEHDN 937
            |.:|   :...:...|.:...:::.||::..:.:..|    |:.:..|.|.    |...:..|..
Mouse   731 PDSH---VEIELELFVNKSTATKLNSGKDTIEDILVLHLERGKDYFLSVSGNYLPSCFGSPIHTL 792

  Fly   938 S-LYEPEVD------SD-----VEIAMDKSNYNENAFLPS-----VGIVMGN--QKED---SPSS 980
            . :.||.:|      ||     |:.|.|:|.......:|.     |..:..|  |:||   .|..
Mouse   793 CYMREPILDLPLKTVSDLTLMSVQTADDRSQLENPMEIPKELWMMVDYLYRNAVQQEDLFQQPGL 857

  Fly   981 SDEIRHLEQKDSMCKTTEDVLTISITSVTDHVGLPTGLLENAPAIRPITPNPLICVEAHEAFDDR 1045
            ..|..|:  :|.:.....|.|..:..||.:.:.|   .||:       .|.|:||   :.|:...
Mouse   858 RPEFDHI--RDCLDTGMIDQLCANNHSVAEALLL---FLES-------LPEPVIC---YSAYHSC 907

  Fly  1046 EEGVKPVSSTSARDLSLPGLPTHPEANKLKQLTSPLSKLAKNIGLN-LDPRKIATKTGVLSPTIL 1109
            .|.....:::....|:||..    ..|....|.:.|.:|.||...| ||...:|:..|.|   :|
Mouse   908 LECSGNYAASKQIILTLPSF----HKNVFNYLMAFLQELLKNSANNHLDENILASIFGSL---LL 965

  Fly  1110 SAENSPPERDPSSRDHLLELWEAEKCK 1136
                    |:| :|...|::.|.:|.:
Mouse   966 --------RNP-ARHQKLDMAEKKKAQ 983

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	11/71 (15%)
		hSac2	663..768	CDD:463592	29/113 (26%)
Inpp5b	XP_006502867.1	INPP5B_PH	1..147	CDD:465268
		INPP5c_INPP5B	346..639	CDD:197327	61/347 (18%)
		RhoGAP_OCRL1	773..991	CDD:239845	58/242 (24%)