DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7956 and Synj1

DIOPT Version :9

Sequence 1:	NP_001036740.2	Gene:	CG7956 / 42545	FlyBaseID:	FBgn0038890	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_011244377.1	Gene:	Synj1 / 104015	MGIID:	1354961	Length:	1714	Species:	Mus musculus

Alignment Length:	1101	Identity:	249/1101 - (22%)
Similarity:	425/1101 - (38%)	Gaps:	236/1101 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 VGIREPRHIERRITEELHKIFDETDSFYFSFDC---DITNNLQRHEAKSEESQSQPDERFFWNK- 239
            :.:|.....|.||: |:.|:.: :.:|||::..   .:..:|..|.:..|.:   .|.|||||:
Mouse   248 ISLRVDASDEDRIS-EVRKVLN-SGNFYFAWSASGVSLDLSLNAHRSMQEHT---TDNRFFWNQS 307

  Fly   240 ---HMIRDLINLNDKTWILPIIQGFMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVDEKGN 301
               |:....:|.:|  |:|.::.|.:::......::.....|:||.|..|||||:..||.::.|:
Mouse   308 LHLHLKHYGVNCDD--WLLRLMCGGVEIRTIYAAHKQAKACLISRLSCERAGTRFNVRGTNDDGH 370

  Fly   302 CANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYK---YRPPPRLDRGVAETQQAFELHFTKE 363
            .||:|||||::.......||.|:|||||::|.|||.:   :|  .|:.||......||:.||...
Mouse   371 VANFVETEQVIYLDDCVSSFIQIRGSVPLFWEQPGLQVGSHR--VRMSRGFEANAPAFDRHFRTL 433

  Fly   364 LETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIY-VTFDFHDYCRGMRFENVSALIDAV 427
            .:.||:..:|||:.....|..:..|:..|:....:...|: |:||:|...:|.:.|.:.:::...
Mouse   434 KDLYGKQIVVNLLGSKEGEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGKAEKLHSILKPQ 498

  Fly   428 GPEAGAMGFHWRDQRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQLVKLGLSPPYTPIP 492
            ..:....||.:.|...:...|....|.||:|||||||.||..:|..:|..||..|||:.. ..:.
Mouse   499 VQKFLDYGFFYFDGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEK-PQLV 562

  Fly   493 EQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSANRFFIQNFADSFRQ 557
            .:.:..|..:|:.|||.||:.||||.||:|       :..:|.:|||..|..|....||.||.:|
Mouse   563 TRFQEVFRSMWSVNGDSISKIYAGTGALEG-------KAKAGKLKDGARSVTRTIQNNFFDSSKQ 620

  Fly   558 CIID-LMQGQLLRAEDLQEDEVLSTILQILTPETR-------------PPLHGYYNPGVL----- 603
            ..|| |:.|..|.::...:...|.|...:...|..             ...:.|..|..:
Mouse   621 EAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKNMCENFYKYSKPKKIRVCVG 685

  Fly   604 ------GPELQLL--ESIVTTSYYLARFKDSYRQATIDLMLGNQVSSESLSALGGQ------AGP 654
                  |.:.:.:  ::...|.:.|    |:.:.|.|......:.....:.|:|.:      ||.
Mouse   686 TWNVNGGKQFRSIAFKNQTLTDWLL----DAPKLAGIQEFQDKRSKPTDIFAIGFEEMVELNAGN 746

  Fly   655 DENDGTEN-----AEQAKLLVEDCRRLLLGTAQYPVGAWGLIDADPSSGD-INETEVDTI----- 708
            ..|..|.|     .|..|.:..|.:.:||.:.|. ||....:...|.... |.:..|||:
Mouse   747 IVNASTTNQKLWAVELQKTISRDNKYVLLASEQL-VGVCLFVFIRPQHAPFIRDVAVDTVKTGMG 810

  Fly   709 ------------LLL--TDDCYIVAEYDSHLDKIVRFEK--VQLTQVRLIELG--MHQQTKIFQG 755
                        :|.  |..|::.:.:.:...::....:  |::.:.....:|  :.....:|
Mouse   811 GATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFVEIARKLSFPMGRMLFSHDYVF-- 873

  Fly   756 SAPAHLCLRLNYSVD----------EQEGYFHMFRSANLRFFNNMAYVIK--TQEEVAESMTSIV 808
                 .|...||.:|          .|:.:..:.....|....|...:.:  .:.:|..:.|...
Mouse   874 -----WCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAGQIFRGFLEGKVTFAPTYKY 933

  Fly   809 EMFRIALDNAGNTEVRYITGGVLQRRKSKLPTLDVPRGMPRNLSESQLVQLS----SKALSNMA- 868
            ::|....|.:........|..||.||: |.|       ..|:..:..|:..|    ||.|....
Mouse   934 DLFSEDYDTSEKCRTPAWTDRVLWRRR-KWP-------FDRSAEDLDLLNASFQDESKILYTWTP 990

  Fly   869 GQFSKLGQTFKKPQAHPSSLAATMNPQVMRQRDSEIESGQEAEKAVFTLGRKHRN----SNSASS 929
            |.....|:...|...| ..:.|.::..:.   :.|.|..|:..|.|..:......    |..:|:
Mouse   991 GTLLHYGRAELKTSDH-RPVVALIDIDIF---EVEAEERQKIYKEVIAVQGPPDGTVLVSIKSSA 1051

  Fly   930 TDTDEHDNSLYEPEVDSDVEIAMDKSNYNENAFL---------------PSVGIVMGNQKE---- 975
            .::...|::|.:       |:....:::.|...:               .::..:..|.||
Mouse  1052 QESTFFDDALID-------ELLRQFAHFGEVILIRFVEDKMWVTFLEGSSALNALSLNGKELLNR 1109

  Fly   976 ---DSPSSSDEIRHLEQKDSMCKTTEDVLTISITSVTDHVGLPTGLLENAPAIRPITPNPLICVE 1037
               .:..|.|.|:|||::.|:.|       ||:|       ||:.           ..:.|:..:
Mouse  1110 TITITLKSPDWIKHLEEEMSLEK-------ISVT-------LPSS-----------ASSTLLGED 1149

  Fly  1038 AHEAFDDREEG----------------------------------VKPVSSTSARDLSLPGLPTH 1068
            |..|.|...||                                  ..|..|.:..:.|.|.||..
Mouse  1150 AEVAADFDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTVPEYSAPSLPIR 1214

  Fly  1069 PEANKLKQLTSPLSK---------LAKNIGLNLDPRKIATKTGVLSPTILSAENSPPERDP 1120
            |.....:....|.|:         ..|:....|:|::......|..|    |..:||:|.|
Mouse  1215 PSRAPSRTPGPPSSQGSPVDTQPAAQKDSSQTLEPKRPPPPRPVAPP----ARPAPPQRPP 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7956	NP_001036740.2	Syja_N	174..413	CDD:280532	76/244 (31%)
		COG5329	<197..586	CDD:227637	128/400 (32%)
		hSac2	663..768	CDD:289241	21/128 (16%)
Synj1	XP_011244377.1	COG5329	204..627	CDD:227637	128/395 (32%)
		INPP5c_Synj1	680..1015	CDD:197332	61/355 (17%)
		RRM_SF	1014..1155	CDD:388407	30/175 (17%)
		PHA03247	<1207..1609	CDD:223021	17/69 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836197
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850