Protein Alignment sp3 and inpp5f

DIOPT Version :10

• Sequence 1: NP_001036740.2
• Gene: sp3 / 42545
• FlyBaseID: FBgn0038890
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: XP_031761377.1
• Gene: inpp5f / 100379801
• XenbaseID: XB-GENE-1008490
• Length: 1106
• Species: Xenopus tropicalis
• Alignment Length: 1262
• Identity: 404/1262 - (32%)
• Similarity: 593/1262 - (46%)
• Gaps: 276/1262 - (21%)

  Fly     1 MEVFQTDSHYIFVKRDKSLWWHRRTSEFSIKAGWDLSSVDDIECIGVTHGIVGVISLPNVYEPHL 65
            ||:||...|||..:.:.:||..|:....:.:|..||....:..|:|:..||:|.:.|.......|
 Frog     1 MELFQAKDHYILQRGESALWCSRQDGSLTSRAATDLLLAWNPICLGLVEGIIGKVQLHTDLPWWL 65

  Fly    66 VVVKEASAVGVLYPPHLVYKIKSICIL---SADDPDTDLPNCTKHTKSNQSTPTHSVSTSNNNNA 127
            :::::.|.:|:|...|.:|||..|..:   .|:..|.:|..|.||         |.
 Frog    66 LLIRQKSLIGILPGGHEIYKINKIAAIPLSGAEPQDLELELCKKH---------HF--------- 112

  Fly   128 SVPSSGGGSSKSTKLFEGMNKTWGAVKSAGNT---IKNTTQQAANL---ATKQVKSSVGIREPRH 186
                             |:||.....:|..::   :|..||..:|:   |.|:||.|   :|...
 Frog   113 -----------------GINKPEKITQSPDDSKFLMKTLTQIKSNVSAPAKKKVKES---KEKER 157

  Fly   187 IERRITEELHKIFDETDSFYFSFDCDITNNLQRHEAKSEESQ----SQPDERFFWNKHMIRDLIN 247
            :|||:.|||.|:|.::||||:|:..|:|:::||..:: |:|.    ...|:|||||||||:|||:
 Frog   158 LERRLLEELFKMFMDSDSFYYSWTYDLTSSVQRQSSR-EKSDLLLWQTVDDRFFWNKHMIQDLID 221

  Fly   248 LND---KTWILPIIQGFMQVENCVIG-NE-----------------C-------FTLALVSRRSR 284
            :.|   ..|||||||||:|:|..|:. ||                 |       |.:||:|||||
 Frog   222 IKDPQGSVWILPIIQGFVQIEELVVNYNESSDDEKSSPETPPQEPTCVDDIHPRFMVALISRRSR 286

  Fly   285 HRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLDRGV 349
            ||||.||||||||:.|:.||||||||::...:|.|||.|.|||||::|||.||:|.|.||||:..
 Frog   287 HRAGMRYKRRGVDKFGHVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDKSE 351

  Fly   350 AETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRG 414
            .||.|.|.|||.:||..|.:..|:|||:|:|:||.|||||...|:..||..|.|||||||::|||
 Frog   352 KETSQYFALHFNQELGIYQKQVIINLVDQAGREKIIGDAYLKQVLMFNNPNLTYVTFDFHEHCRG 416

  Fly   415 MRFENVSALIDAVGPEAGAMGFHWRDQRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQL 479
            |:||||..|.||:......|.:.|.||.|:||.|:.:||||||||||||||||.|:.:.::|.||
 Frog   417 MKFENVQTLTDAISDIIVDMKWCWVDQAGVICKQEGIFRVNCMDCLDRTNVVQAAVARVIMEHQL 481

  Fly   480 VKLGLSPPYTPIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSAN 544
            .|||:.||..|:|.:....:.::||||||.||||||||.|||||:|||||||::|:||||:||||
 Frog   482 KKLGVMPPEQPLPMKCYRLYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSAN 546

  Fly   545 RFFIQNFADSFRQCIIDLMQGQLLRAEDLQEDEVLSTILQILTPETRPPLHGYYNPGVLGPELQL 609
            |:::..|.|::||.:|||||| :...|||         ..|.|.|..
 Frog   547 RYYLNRFKDAYRQAVIDLMQG-IPVTEDL---------YSIFTKEKE------------------ 583

  Fly   610 LESIVTTSYYLARFKDSYRQATIDLMLGNQVSSESLSALGGQAGPDENDGTENAEQAKLLVEDCR 674
                     :.|..::|.|                                .:.|....|:::..
 Frog   584 ---------HEALHRESQR--------------------------------NHHELINQLLQNYM 607

  Fly   675 RLLLGTAQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQV 739
            ::||...:...|.|.|||.|||..|....:|:.:|||::..|.||.||..:||:.:::::.|..:
 Frog   608 QMLLPDDEKFHGGWALIDCDPSLIDATHRDVEVLLLLSNCAYYVAYYDDEIDKVNQYQRLSLEDL 672

  Fly   740 RLIELGMHQQTKIFQGSAPAHLCLRLNYSVDEQEGYFHMFRSANLRFFNNMAYVIKTQEEVAESM 804
            ..||:|   ....|.|. |...|:||:|......||||..|          |......|:..:::
 Frog   673 ERIEIG---PEPTFFGK-PKFSCMRLHYKYKGNSGYFHTLR----------AVTRNPDEDGKDTL 723

  Fly   805 TSIVEMFRIA--------------LDNAGNTEVRYITGGVLQRRKSKLPTLDVPRGMPRNLSESQ 855
            ..|.||.|:.              |:...:.....|.|  ::.|..:|....:.....:|...|:
 Frog   724 LCIAEMLRLTKQALELDVPVIEKKLERKSSKPHEEIIG--IRSRSQRLGLNSMGLAQSKNFLMSK 786

  Fly   856 LVQLSSKALSNMAGQFSKLGQTFKKPQAHPSSLAATMNPQVMRQRDSEIESGQEAEKAVFTLGRK 920
            ...|:.|......|...||| .|.||.. ...||..:...:.:...|....|.:.        :.
 Frog   787 FSSLNQKVKQTNIGSLRKLG-GFNKPDG-KGVLAPNLQANMWKSDSSLDNPGTDI--------KG 841

  Fly   921 HRNSNSASSTDTDE-HDNSLYEPEVDSDVEIAMDKSNYNENAF-LPSVGIVMG----NQKEDSPS 979
            |..|:...|||::. |.:.......:.|.:.|....|..:..: |||.||::.    ..:..|.|
 Frog   842 HPESDLDISTDSESFHSDDFLTKSDEEDGQSAGALENMGQTDYVLPSCGIIVSVPRLGSRSHSVS 906

  Fly   980 SSD-------EIRHLEQKDSMCKTTEDVLTISI-------------------------------- 1005
            |:|       ||...|.::.....||.::....
 Frog   907 SADFNPPNPTEIHVTECEEQDPPQTEALVDFGTPIDAYCHQFVHDAQTKGNLNEPDSKEAQLDQE 971

  Fly  1006 TSVTDHVGLPTGLLENAPAIRPITPNPLICVEAHEAFDDREEGVKPV-------SSTSARDLSLP 1063
            ||..:...:|..|..:|..|    |.|.....:|.:.:.:...|:|.       :|.::...|.|
 Frog   972 TSSNNSPKIPAPLESDAELI----PRPSQLDVSHNSANSQLLPVEPPQLSKSGRASPASASTSAP 1032

  Fly  1064 GLPTHPEANKLKQLTSPLSKLAKNI-------------GLNLDPRKIATKTGVLSPTILSAENSP 1115
            .    |..:...:..||.:|:..::             |:|....|:..     ||.    .|:|
 Frog  1033 S----PADSSSSRAVSPFAKIRSSVVQVANITQAGLTQGINFAVAKVQK-----SPD----PNAP 1084

  Fly  1116 PERDPSSRDHLLELWEAEKCKTKLIAL 1142
            ||  |...| ..:|:  .:|:|::|.:
 Frog  1085 PE--PPQND-FKDLF--TQCQTRIIQI 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sp3	NP_001036740.2	COG5329	<197..586	CDD:227637	221/420 (53%)
		hSac2	663..768	CDD:463592	34/104 (33%)
inpp5f	XP_031761377.1	COG5329	50..567	CDD:227637	256/555 (46%)
		hSac2	597..697	CDD:463592	34/103 (33%)