DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7956 and inpp5f

DIOPT Version :9

Sequence 1:	NP_001036740.2	Gene:	CG7956 / 42545	FlyBaseID:	FBgn0038890	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_031761377.1	Gene:	inpp5f / 100379801	XenbaseID:	XB-GENE-1008490	Length:	1106	Species:	Xenopus tropicalis

Alignment Length:	1262	Identity:	404/1262 - (32%)
Similarity:	593/1262 - (46%)	Gaps:	276/1262 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVFQTDSHYIFVKRDKSLWWHRRTSEFSIKAGWDLSSVDDIECIGVTHGIVGVISLPNVYEPHL 65
            ||:||...|||..:.:.:||..|:....:.:|..||....:..|:|:..||:|.:.|.......|
Frog     1 MELFQAKDHYILQRGESALWCSRQDGSLTSRAATDLLLAWNPICLGLVEGIIGKVQLHTDLPWWL 65

  Fly    66 VVVKEASAVGVLYPPHLVYKIKSICIL---SADDPDTDLPNCTKHTKSNQSTPTHSVSTSNNNNA 127
            :::::.|.:|:|...|.:|||..|..:   .|:..|.:|..|.||         |.
Frog    66 LLIRQKSLIGILPGGHEIYKINKIAAIPLSGAEPQDLELELCKKH---------HF--------- 112

  Fly   128 SVPSSGGGSSKSTKLFEGMNKTWGAVKSAGNT---IKNTTQQAANL---ATKQVKSSVGIREPRH 186
                             |:||.....:|..::   :|..||..:|:   |.|:||.|   :|...
Frog   113 -----------------GINKPEKITQSPDDSKFLMKTLTQIKSNVSAPAKKKVKES---KEKER 157

  Fly   187 IERRITEELHKIFDETDSFYFSFDCDITNNLQRHEAKSEESQ----SQPDERFFWNKHMIRDLIN 247
            :|||:.|||.|:|.::||||:|:..|:|:::||..:: |:|.    ...|:|||||||||:|||:
Frog   158 LERRLLEELFKMFMDSDSFYYSWTYDLTSSVQRQSSR-EKSDLLLWQTVDDRFFWNKHMIQDLID 221

  Fly   248 LND---KTWILPIIQGFMQVENCVIG-NE-----------------C-------FTLALVSRRSR 284
            :.|   ..|||||||||:|:|..|:. ||                 |       |.:||:|||||
Frog   222 IKDPQGSVWILPIIQGFVQIEELVVNYNESSDDEKSSPETPPQEPTCVDDIHPRFMVALISRRSR 286

  Fly   285 HRAGTRYKRRGVDEKGNCANYVETEQILSFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLDRGV 349
            ||||.||||||||:.|:.||||||||::...:|.|||.|.|||||::|||.||:|.|.||||:..
Frog   287 HRAGMRYKRRGVDKFGHVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDKSE 351

  Fly   350 AETQQAFELHFTKELETYGRVCIVNLVEQSGKEKTIGDAYADHVIKLNNDRLIYVTFDFHDYCRG 414
            .||.|.|.|||.:||..|.:..|:|||:|:|:||.|||||...|:..||..|.|||||||::|||
Frog   352 KETSQYFALHFNQELGIYQKQVIINLVDQAGREKIIGDAYLKQVLMFNNPNLTYVTFDFHEHCRG 416

  Fly   415 MRFENVSALIDAVGPEAGAMGFHWRDQRGMICNQKSVFRVNCMDCLDRTNVVQTAIGKAVLESQL 479
            |:||||..|.||:......|.:.|.||.|:||.|:.:||||||||||||||||.|:.:.::|.||
Frog   417 MKFENVQTLTDAISDIIVDMKWCWVDQAGVICKQEGIFRVNCMDCLDRTNVVQAAVARVIMEHQL 481

  Fly   480 VKLGLSPPYTPIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTGERKISGMMKDGMNSAN 544
            .|||:.||..|:|.:....:.::||||||.||||||||.|||||:|||||||::|:||||:||||
Frog   482 KKLGVMPPEQPLPMKCYRLYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSAN 546

  Fly   545 RFFIQNFADSFRQCIIDLMQGQLLRAEDLQEDEVLSTILQILTPETRPPLHGYYNPGVLGPELQL 609
            |:::..|.|::||.:|||||| :...|||         ..|.|.|..
Frog   547 RYYLNRFKDAYRQAVIDLMQG-IPVTEDL---------YSIFTKEKE------------------ 583

  Fly   610 LESIVTTSYYLARFKDSYRQATIDLMLGNQVSSESLSALGGQAGPDENDGTENAEQAKLLVEDCR 674
                     :.|..::|.|                                .:.|....|:::..
Frog   584 ---------HEALHRESQR--------------------------------NHHELINQLLQNYM 607

  Fly   675 RLLLGTAQYPVGAWGLIDADPSSGDINETEVDTILLLTDDCYIVAEYDSHLDKIVRFEKVQLTQV 739
            ::||...:...|.|.|||.|||..|....:|:.:|||::..|.||.||..:||:.:::::.|..:
Frog   608 QMLLPDDEKFHGGWALIDCDPSLIDATHRDVEVLLLLSNCAYYVAYYDDEIDKVNQYQRLSLEDL 672

  Fly   740 RLIELGMHQQTKIFQGSAPAHLCLRLNYSVDEQEGYFHMFRSANLRFFNNMAYVIKTQEEVAESM 804
            ..||:|   ....|.|. |...|:||:|......||||..|          |......|:..:::
Frog   673 ERIEIG---PEPTFFGK-PKFSCMRLHYKYKGNSGYFHTLR----------AVTRNPDEDGKDTL 723

  Fly   805 TSIVEMFRIA--------------LDNAGNTEVRYITGGVLQRRKSKLPTLDVPRGMPRNLSESQ 855
            ..|.||.|:.              |:...:.....|.|  ::.|..:|....:.....:|...|:
Frog   724 LCIAEMLRLTKQALELDVPVIEKKLERKSSKPHEEIIG--IRSRSQRLGLNSMGLAQSKNFLMSK 786

  Fly   856 LVQLSSKALSNMAGQFSKLGQTFKKPQAHPSSLAATMNPQVMRQRDSEIESGQEAEKAVFTLGRK 920
            ...|:.|......|...||| .|.||.. ...||..:...:.:...|....|.:.        :.
Frog   787 FSSLNQKVKQTNIGSLRKLG-GFNKPDG-KGVLAPNLQANMWKSDSSLDNPGTDI--------KG 841

  Fly   921 HRNSNSASSTDTDE-HDNSLYEPEVDSDVEIAMDKSNYNENAF-LPSVGIVMG----NQKEDSPS 979
            |..|:...|||::. |.:.......:.|.:.|....|..:..: |||.||::.    ..:..|.|
Frog   842 HPESDLDISTDSESFHSDDFLTKSDEEDGQSAGALENMGQTDYVLPSCGIIVSVPRLGSRSHSVS 906

  Fly   980 SSD-------EIRHLEQKDSMCKTTEDVLTISI-------------------------------- 1005
            |:|       ||...|.::.....||.::....
Frog   907 SADFNPPNPTEIHVTECEEQDPPQTEALVDFGTPIDAYCHQFVHDAQTKGNLNEPDSKEAQLDQE 971

  Fly  1006 TSVTDHVGLPTGLLENAPAIRPITPNPLICVEAHEAFDDREEGVKPV-------SSTSARDLSLP 1063
            ||..:...:|..|..:|..|    |.|.....:|.:.:.:...|:|.       :|.::...|.|
Frog   972 TSSNNSPKIPAPLESDAELI----PRPSQLDVSHNSANSQLLPVEPPQLSKSGRASPASASTSAP 1032

  Fly  1064 GLPTHPEANKLKQLTSPLSKLAKNI-------------GLNLDPRKIATKTGVLSPTILSAENSP 1115
            .    |..:...:..||.:|:..::             |:|....|:..     ||.    .|:|
Frog  1033 S----PADSSSSRAVSPFAKIRSSVVQVANITQAGLTQGINFAVAKVQK-----SPD----PNAP 1084

  Fly  1116 PERDPSSRDHLLELWEAEKCKTKLIAL 1142
            ||  |...| ..:|:  .:|:|::|.:
Frog  1085 PE--PPQND-FKDLF--TQCQTRIIQI 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7956	NP_001036740.2	Syja_N	174..413	CDD:280532	136/270 (50%)
		COG5329	<197..586	CDD:227637	221/420 (53%)
		hSac2	663..768	CDD:289241	34/104 (33%)
inpp5f	XP_031761377.1	COG5329	50..567	CDD:227637	256/555 (46%)
inpp5f	XP_031761377.1	hSac2	597..697	CDD:403601	34/103 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	281	1.000	Domainoid score	I1648
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8962
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153624at33208
OrthoFinder	1	1.000	-	-		FOG0006012
OrthoInspector	1	1.000	-	-		oto103424
Panther	1	1.100	-	-	LDO	PTHR45662
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4310
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.110