DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C15 and Pax4

DIOPT Version :9

Sequence 1:	NP_476873.2	Gene:	C15 / 42544	FlyBaseID:	FBgn0004863	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_113987.1	Gene:	Pax4 / 83630	RGDID:	620433	Length:	349	Species:	Rattus norvegicus

Alignment Length:	156	Identity:	50/156 - (32%)
Similarity:	64/156 - (41%)	Gaps:	23/156 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 LHHAALAHQAVKDRLAAAFPIARRIGHPYQNRTPPKRKKP------RTSFTRIQVAELEKRFHKQ 239
            ||...|...||   ||.|.|      .|:.|...|:...|      ||.|:..|...|||.|.:.
  Rat   137 LHWTQLRSPAV---LAPALP------SPHSNCEAPRGPHPGTSHRNRTIFSPGQAEALEKEFQRG 192

  Fly   240 KYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANR-LMLSLQAEAISKGF 303
            :|..|..|..||....:.:..|:.||.|||.|||||...:.|.:...|:: ||:...:..|....
  Rat   193 QYPDSVVRGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWETQMPGASQDLMVPKDSPGIISAQ 257

  Fly   304 APPSAPLGSQGGVNGAPLAALHGLQP 329
            ..|       |.|..|.|..|..|.|
  Rat   258 QSP-------GSVPSAALPVLEQLNP 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	37/125 (30%)
C15	NP_476873.2	Homeobox	220..273	CDD:278475	21/58 (36%)
Pax4	NP_113987.1	PAX	5..129	CDD:128645
		PAI subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	8..64
		RED subdomain. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00381	83..131
		Homeobox	174..226	CDD:278475	20/51 (39%)
		Transcription repression	278..349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910