DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C15 and lbx2

DIOPT Version :9

Sequence 1:	NP_476873.2	Gene:	C15 / 42544	FlyBaseID:	FBgn0004863	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001007135.1	Gene:	lbx2 / 64276	ZFINID:	ZDB-GENE-001206-2	Length:	257	Species:	Danio rerio

Alignment Length:	304	Identity:	81/304 - (26%)
Similarity:	119/304 - (39%)	Gaps:	92/304 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SGSDVDMDGGSCYDES-----ETPLSESLQSEQTRSSSSENLPFSISRLLSKPFETSHHHHNNNN 97
            :.|..||..||....|     ..||.   |.....:|:....||||..:|:||............
Zfish     2 TSSSKDMKAGSVLQSSGEERRRGPLD---QLPPPANSNKPLTPFSIEDILNKPSVKKSVGSLCPP 63

  Fly    98 HLLSSSPGSSSNNNNSGEKGEEKELLQQEDHDLAYK----LATSIANSTYGSAAALYSYPHLYPS 158
            .:|....|||::.|  |.......|...|  :||.|    |..|:..:..|.       .|:  :
Zfish    64 RVLEKVTGSSASRN--GISAPSSPLCALE--ELASKTFKGLEVSVIQAAEGR-------EHI--N 115

  Fly   159 AAGGHVLRVPPQRTPLTWALPPLHHAALAHQAVKDRLAAAFPIARRIGHPYQNRTPPKRKKPRTS 223
            |.|                                                |.:...||:|.||:
Zfish   116 AFG------------------------------------------------QRQASKKRRKSRTA 132

  Fly   224 FTRIQVAELEKRFHKQKYLASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAAN 288
            ||..|:.||||||..||||:.|:|..:|:.|.:|:|||.|||||||.|.:|. .||.:|:.::..
Zfish   133 FTNHQIYELEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRD-LEEMKADVESLK 196

  Fly   289 RL-------MLSLQ--------AEAISKGFAP---PSAPLGSQG 314
            ::       ::|::        :..||...:|   |.:|..|:|
Zfish   197 KIPPQALQKLVSMEDMEDAHGGSGPISPSLSPRAFPQSPSSSRG 240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	47/137 (34%)
C15	NP_476873.2	Homeobox	220..273	CDD:278475	31/52 (60%)
lbx2	NP_001007135.1	Required for convergent extension movement and hypaxial myogenesis during gastrulation. Required for the formation of thick and thin myofilaments. Required for myod1 expression in the pectoral fin bud. Required for continuous expression of cxcl12a in the posterior lateral mesoderm at the tail bud stage and in adaxial cells at the 10-somite stage. /evidence=ECO:0000269\|PubMed:19216761, ECO:0000269\|PubMed:22216300, ECO:0000269\|PubMed:22406073	1..46		14/46 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43		11/43 (26%)
		Homeobox	129..183	CDD:395001	31/53 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..257		8/35 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810