DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C15 and npm1b

DIOPT Version :9

Sequence 1:	NP_476873.2	Gene:	C15 / 42544	FlyBaseID:	FBgn0004863	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	XP_005173145.2	Gene:	npm1b / 553507	ZFINID:	ZDB-GENE-080723-7	Length:	316	Species:	Danio rerio

Alignment Length:	234	Identity:	44/234 - (18%)
Similarity:	75/234 - (32%)	Gaps:	87/234 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SHEEDDHEHENEHG----------EEVEEQEIHVDVDSDSRMSCGSGSDVDMDGGSCYDESETPL 57
            |.:||:.|.||...          .:|.::::.:|.|.|.    .|..|.|.|.....||.|...
Zfish   137 SDDEDEEEEENNTSPVKRPSNMTLAKVPQKKLKMDSDEDE----DSDDDDDDDDDDDDDEEEDDD 197

  Fly    58 SESLQSEQTRSSSSENLPFSISRLLSKPFETSHHHHNNNNHLLSSSPGSSSNNNNSGEKGEEKEL 122
            .:...:.::...|::..|                     ....|:...:.|.:..:|..|:.:..
Zfish   198 KQEKPAVKSPVKSTQKTP---------------------EKKKSADKQNGSPDKKAGTSGKPQTQ 241

  Fly   123 LQQEDHDLAYKLATSIANSTYGSAAALYSYPHLYPSAAGGHVLRVPPQRTPLTWALPPLHHAALA 187
            ..|:..|                           .||||      |..:||   ::|.|
Zfish   242 TPQKVKD---------------------------KSAAG------PSGKTP---SIPSL------ 264

  Fly   188 HQAVKDRLAAAFPIARRIGHPYQNRTPPKRKKPRTSFTR 226
             ..||.:|.:    |.:.|.|:     ||.::...:|.|
Zfish   265 -SEVKSKLTS----AAKEGKPF-----PKTEQKFENFAR 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	7/31 (23%)
C15	NP_476873.2	Homeobox	220..273	CDD:278475	2/7 (29%)
npm1b	XP_005173145.2	Nucleoplasmin	32..131	CDD:308605
npm1b	XP_005173145.2	NPM1-C	265..313	CDD:318505	10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900