DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C15 and NPM1

DIOPT Version :9

Sequence 1:	NP_476873.2	Gene:	C15 / 42544	FlyBaseID:	FBgn0004863	Length:	339	Species:	Drosophila melanogaster
Sequence 2:	NP_001341935.1	Gene:	NPM1 / 4869	HGNCID:	7910	Length:	294	Species:	Homo sapiens

Alignment Length:	154	Identity:	35/154 - (22%)
Similarity:	55/154 - (35%)	Gaps:	39/154 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 EDDHEHENEHGEEVEEQEIHVDVDSDSRMSCGSGS-----------DVDMDGGSCYDESETPLSE 59
            |:|.|.|:|..|:|:...|     |..|.:.|.||           |.|.|.....|:.|....:
Human   120 EEDAESEDEEEEDVKLLSI-----SGKRSAPGGGSKVPQKKVKLAADEDDDDDDEEDDDEDDDDD 179

  Fly    60 SLQSEQTRSSSSENLPFSISRLLSKPFETSHHHHNNNNHLLSSSPGSSSNNNNSGEKGEEKELLQ 124
            ....|:    :.|..|...| :...|.:.:...:.|..   .|.|.|:..:     ||:|....|
Human   180 DFDDEE----AEEKAPVKKS-IRDTPAKNAQKSNQNGK---DSKPSSTPRS-----KGQESFKKQ 231

  Fly   125 QED----------HDLAYKLATSI 138
            ::.          .|:..|:..||
Human   232 EKTPKTPKGPSSVEDIKAKMQASI 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863
C15	NP_476873.2	Homeobox	220..273	CDD:278475
NPM1	NP_001341935.1	Required for interaction with SENP3	1..186		19/74 (26%)
		Necessary for interaction with APEX1. /evidence=ECO:0000269\|PubMed:19188445	1..117
		Nucleoplasmin	18..117	CDD:397268
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..247		31/144 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		0/4 (0%)
		Nuclear localization signal. /evidence=ECO:0000255	191..197		2/6 (33%)
		Required for nucleolar localization	243..294		4/13 (31%)
		NPM1-C	245..291	CDD:406641	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900