DRSC/TRiP Functional Genomics Resources

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Protein Alignment C15 and NKX6-1

DIOPT Version :10

Sequence 1:NP_476873.2 Gene:C15 / 42544 FlyBaseID:FBgn0004863 Length:339 Species:Drosophila melanogaster
Sequence 2:NP_006159.2 Gene:NKX6-1 / 4825 HGNCID:7839 Length:367 Species:Homo sapiens


Alignment Length:363 Identity:103/363 - (28%)
Similarity:135/363 - (37%) Gaps:114/363 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 ESETPLSESL----------QSEQTRSSSSENLPF--------------SISRLLSKPFETSHHH 92
            |.:|||..:.          .|..:.||||.:.|.              .:|.|.|.|.:.|...
Human    30 EMKTPLYPAAYPPLPAGPPSSSSSSSSSSSPSPPLGTHNPGGLKPPATGGLSSLGSPPQQLSAAT 94

  Fly    93 HNNNNHLL--------------SSSPGSSSNNNNSGEKGEEKELLQQEDHDLAYKLATSIANSTY 143
            .:..|.:|              |:||..||::::|...........     .|...|.:.|:|..
Human    95 PHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASASSASAAA-----AAAAAAAAAASSPA 154

  Fly   144 GSAAALYSY---------PHLY--PSAAG-GHVLRVP------PQRTPLTW----ALPPLHHAAL 186
            |..|.|..:         |.||  ||||. ..|.|.|      |.|||:.|    ..||...|.|
Human   155 GLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARL 219

  Fly   187 A---HQAV----KDRLAAAFPIARRIGHPYQNRTPPKRKKPRTSFTRIQVAELEKRFHKQKYLAS 244
            |   ||..    ||                     .|||..|.:|:..|:..|||.|.:.||||.
Human   220 ACTPHQGSILLDKD---------------------GKRKHTRPTFSGQQIFALEKTFEQTKYLAG 263

  Fly   245 AERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEE----REAERQAANRLMLSLQAEAISKGFAP 305
            .|||.||..|.||::|||.||||||||||::.|.|    ::.:.....||..:.:.|.....:..
Human   264 PERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGASENEEEDDDYNK 328

  Fly   306 PSAP--------------LGSQGGVNGAPLAALHGLQP 329
            |..|              ..|.||..|   ..||..:|
Human   329 PLDPNSDDEKITQLLKKHKSSSGGGGG---LLLHASEP 363

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C15NP_476873.2 COG5576 <196..315 CDD:227863 43/136 (32%)
Homeodomain 218..274 CDD:459649 32/55 (58%)
NKX6-1NP_006159.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..133 19/96 (20%)
Repressor domain. /evidence=ECO:0000250 102..268 54/191 (28%)
Homeodomain 235..293 CDD:459649 34/57 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 294..367 14/73 (19%)
Involved in DNA-binding. /evidence=ECO:0000250 306..367 12/61 (20%)

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