Protein Alignment C15 and MSX2

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_002440.2
• Gene: MSX2 / 4488
• HGNCID: 7392
• Length: 267
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 75/282 - (26%)
• Similarity: 109/282 - (38%)
• Gaps: 93/282 - (32%)

  Fly    63 SEQTRSSSSENLPFSISRLLS--KPFETSHHHHNNNNHLLSSSPGSSSNNNNSGEKGEEKELLQQ 125
            :|:.|...| :||||:..|:|  ||.:.:           |..|..|:
Human    35 AEERRVKVS-SLPFSVEALMSDKKPPKEA-----------SPLPAESA----------------- 70

  Fly   126 EDHDLAYKLATSIANSTYGSAAALYSYPHLYPSAAGGHVLRVPPQRTPLTWALPPLHHAALAHQA 190
                               ||.|.     |.|....||..|......||   :.|...|::..:.
Human    71 -------------------SAGAT-----LRPLLLSGHGAREAHSPGPL---VKPFETASVKSEN 108

  Fly   191 VKDRLAAAFPIARRIGHPYQNRTPPK--------------RKKPRTSFTRIQVAELEKRFHKQKY 241
            .:|  .||:     :..|.:...||:              .:||||.||..|:..||::|.:::|
Human   109 SED--GAAW-----MQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQY 166

  Fly   242 LASAERAALARGLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLS-----------LQ 295
            |:.||||..:..|.:|:.|||.||||||.|.:|....|.|..:.||..::.|           ||
Human   167 LSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSSFSLPFPISSPLQ 231

  Fly   296 AEAI---SKGFAPPSAPLGSQG 314
            |.:|   |..|..|..|:...|
Human   232 AASIYGASYPFHRPVLPIPPVG 253

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	48/147 (33%)
		Homeodomain	218..274	CDD:459649	28/55 (51%)
MSX2	NP_002440.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		14/83 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..147		5/30 (17%)
		Homeodomain	143..199	CDD:459649	28/55 (51%)