Protein Alignment C15 and MEOX2

DIOPT Version :10

• Sequence 1: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Sequence 2: NP_005915.2
• Gene: MEOX2 / 4223
• HGNCID: 7014
• Length: 304
• Species: Homo sapiens
• Alignment Length: 745
• Identity: 140/745 - (18%)
• Similarity: 229/745 - (30%)
• Gaps: 260/745 - (34%)

  Fly   184 PSTLNDSREEAIAIALGTVGEQDGGNAEYLAPIRCSSTGGMLVAVYEDAQHRWTACVNGSAAPAR 248
            |.:.:|..|:|: ::||.|.:        :|.:| .:....|.||....:..:|
Human    19 PGSRDDRLEDAL-LSLGAVID--------IAGLR-QAARDALSAVLPKVETVYT----------- 62

  Fly   249 YLLTTTGNSVVV---KVSKLPQPTAVQP-----------GIGASG----------APVPPASSPS 289
            |||  .|.|.:|   ...:|||...::.           |:|.|.          ||:.|.....
Human    63 YLL--DGESRLVCEDPPHELPQEGKIREAVISQKRLSCNGLGPSDLLGKPLARLVAPLAPDMQVL 125

  Fly   290 SSPLSPSSSSSSAALPAPDNGTATLLFEYRANPIESITSRCAFGWIATTQFCIAPVERRLPWQEA 354
            ..||....:.|.||:.....|..:...|.....:|.      ...:|..:  :..:::|.|
Human   126 VIPLLDKETGSVAAVILVHCGQLSDSEEQSLQVVEK------HALVALRR--VQALQQRRP---- 178

  Fly   355 EAECNRLGGHLMSIRSSEDQQLIDQLLFNSPGYKDDN---------AYWIGASDLIVE------- 403
            ||..|      .|:.:||||:       :..||.|.:         .:.:.|:.|.::
Human   179 EAVQN------TSVDASEDQK-------DEKGYTDHDRKILQLCGELFDLDATSLQLKVLQYLQQ 230

  Fly   404 ------------------------GDFRWNDKFAFTYSNWFPGWVHQENYNRQPNDDGLSGQDCV 444
                                    ||....::.:|..:....|.|.::....|..|  |:..|..
Human   231 ETQATHCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTMGRLGQVVEDKQCIQLKD--LTSDDVQ 293

  Fly   445 EIRRHFQIAASGGQTVPTVSPLT-----LSYMWNDRNCDARNYFLCERMMDEELPERLWNESECN 504
            :::............||.:|..|     |:..:|....|   :|..|   ||.:.:..::.:...
Human   294 QLQNMLGCELQAMLCVPVISRATDQVVALACAFNKLGGD---FFTDE---DEHVIQHCFHYTGTV 352

  Fly   505 VTVTLSAERPKATVWSPGFPQQYPDSVDCYTLIQAPVGYRVVLD-----FEEMV-----LENEPL 559
            :|.||:            |.::.....:|..|:|........||     .:|::     |.|..:
Human   353 LTSTLA------------FQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEI 405

  Fly   560 CS---YDYLQLVEPDGIGPYVPSKSAKDFSSTVLFRFRNSRHSGRYSAAQHRRKSTKTGGQSAPA 621
            ||   .|..:||             ||.|...|:   .:..:..|..|.|.......|.||
Human   406 CSVFLLDQNELV-------------AKVFDGGVV---DDESYEIRIPADQGIAGHVATTGQ---- 450

  Fly   622 TGDPAGGEQSGPPRTDISFNVPSIVLQP---------SDARYTSSLPLP-------ELSLGSVPR 670
                             ..|:|.....|         :..|..:.|..|       .:.:..:..
Human   451 -----------------ILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVN 498

  Fly   671 KICGDWSSK----LKLLRYVTAGPSLG----------VRFVSDYSNNYGGYKAKISMENVTSECH 721
            ||.|.|.||    |.....:..|.|:.          .::.|..:|....|..|:|.:..|...|
Human   499 KINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLH 563

  Fly   722 DERFKAYNNSCYLIISYPDVDWTTAQQICRGIGAQLASISTTDEQRFITSNIRNSLDYTPRSLYW 786
            |                             ||....|          |.||..| ..||||||
Human   564 D-----------------------------GIQPVAA----------IDSNFAN-FTYTPRSL-- 586

  Fly   787 VGGEITNTGSLEWVDGVKLLFEVPASFPTL 816
             ..:.|:...|..:..:..:.......|||
Human   587 -PEDDTSMAILSMLQDMNFINNYKIDCPTL 615

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C15	NP_476873.2	COG5576	<196..315	CDD:227863	30/142 (21%)
		Homeodomain	218..274	CDD:459649	13/69 (19%)
MEOX2	NP_005915.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	63..192		32/148 (22%)
		COG5576	160..284	CDD:227863	22/148 (15%)
		Homeodomain	188..244	CDD:459649	9/62 (15%)